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Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis 项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2021
负责人:  HUNG, CHIUNG YU
收藏  |  浏览/下载：27/0  |  提交时间：2021/08/12
acute infection  Adverse effects  Affect  Americas  Amphotericin B  Animals  Antifungal Agents  Antimicrobial Resistance  Area  base  Biological Assay  Caliber  Caspofungin  Cell Membrane Permeability  Cell Wall  Cells  chemotherapy  Clinical  Coccidioides  Coccidioides immitis  Coccidioides posadasii  Coccidioidomycosis  Communities  Containment  Contracts  cost  Cryptococcus  Cryptococcus neoformans  Cytochrome P450  Cytology  cytotoxicity  Data  Databases  desert fever  Development  Diagnosis  Disease  Dose  drug development  Drug usage  drug use screening  Flow Cytometry  Fluconazole  follow-up  fungus  Goals  Government  Growth  Hand  Human  Hyphae  Image  In Vitro  in vivo  Incubated  indexing  Infection  Inhalation  insight  Lead  Legal patent  Libraries  Life Cycle Stages  Lower respiratory tract structure  Lung  Lung diseases  Medical  Medical Research  Meningitis  Methods  Mexico  Microscope  Morphology  Motivation  Mycoses  Neuraxis  novel  novel strategies  novel therapeutics  off-patent  pathogen  pathogenic fungus  Patients  Pharmaceutical Preparations  Pharmacology  Phase IV Clinical Trials  Phenotype  Pneumonia  preclinical development  prevent  Process  Property  Reporting  Reproduction spores  Research Personnel  resistant strain  Resolution  screening  small molecule libraries  Soil  South America  Southwestern United States  Speed  success  Symptoms  synergism  Techniques  Testing  The science of Mycology  Time  Toxic effect  United States  United States National Institutes of Health  Vaccines  
Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum 项目
项目编号: 1R01AI148561-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2025
负责人:  RAPPLEYE, CHAD A
收藏  |  浏览/下载：40/0  |  提交时间：2021/08/12
Address  alpha ketoglutarate  Amino Acid Permease  Amino Acid Transporter  Amino Acids  Attenuated  base  Carbon  Catabolism  Cells  Citric Acid Cycle  Coccidioidomycosis  Complement  Consumption  Data  desert fever  Diagnosis  Disease  Environment  Enzymes  Funding Opportunities  fungus  Genes  Genetic  Genetic Screening  Genetic screening method  Genetic Transcription  Genus Hippocampus  Gluconeogenesis  Glutamate Dehydrogenase  Glutamates  Glycolysis  Goals  Growth  Histoplasma  Histoplasma capsulatum  Histoplasmosis  Immune system  Immunocompetent  Immunocompromised Host  Impairment  In Vitro  in vivo  Individual  Infection  Innate Immune System  interdisciplinary approach  Invaded  Investigation  Isotope Labeling  Lung  Lung diseases  macrophage  Measurement  Metabolic  Metabolic Pathway  metabolic profile  Metabolism  metabolomics  Mitochondria  Molecular  Molecular Biology  Molecular Genetics  mouse model  mutant  Mutation  Mycoses  new therapeutic target  novel strategies  novel therapeutics  Nutrient  Nutritional  Nutritional Requirements  parasitism  pathogen  Pathogenesis  pathogenic fungus  Pathway interactions  Peptides  Phagocytes  Phagosomes  prevent  Proliferating  Reaction  residence  Resources  Respiration  response  RNA Interference  Saccharomyces cerevisiae  Source  Substrate Specificity  Systemic disease  Testing  Therapeutic  Time  transcriptomics  uptake  Virulence  Yeasts  
Eco-friendly Management of Bacterial Wilt in Tomato Using Dried Powder of the Wild Arid-Land Medicinal Shrub Rhazya stricta 期刊论文
发表期刊: PLANT DISEASE. 出版年: 2020, 卷号: 104, 期号: 10, 页码: 2613-2621
作者:  Khan, Raja Asad Ali;  Alam, Syed Sartaj;  Hayat, Sania;  Ahmad, Musharaf;  Ali, Asad;  Naz, Ishrat;  Li, Yan
收藏  |  浏览/下载：18/0  |  提交时间：2021/01/07
Rhazya stricta  succulent shoot powder  zone of inhibition  in vivo  in vitro  tomato bacterial wilt  Ralstonia solanacearum  
Management of bacterial wilt in tomato using dried powder of Withania coagulan (L) Dunal 期刊论文
发表期刊: AUSTRALASIAN PLANT PATHOLOGY. 出版年: 2019, 卷号: 48, 期号: 2, 页码: 183-192
作者:  Najeeb, S.;  Ahmad, M.;  Khan, Raja A. A.;  Naz, I.;  Ali, A.;  Alam, Syed S.
收藏  |  浏览/下载：24/0  |  提交时间：2019/11/29
Zones of inhibition  In-vivo  In-vitro  Aqueous extracts  
Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人:  KHANNA, RAJESH
收藏  |  浏览/下载：38/0  |  提交时间：2021/08/12
Absence of pain sensation  addiction  Affect  Afferent Neurons  American  Amitriptyline  Analgesics  analog  Antidepressive Agents  Arizona  Axon  Baclofen  base  Betulinic Acid  Biological Assay  biophysical properties  Calcium  Calcium Channel Blockers  Calcium Channel Inhibition  cancer pain  Cancer Patient  cancer survival  cancer therapy  Cell-Mediated Cytolysis  Cells  central sensitization  chemotherapeutic agent  chemotherapy  Chemotherapy-induced peripheral neuropathy  Chemotherapy-Oncologic Procedure  Chronic  chronic pain  chronic pain relief  chronic painful condition  Clinical  Clinical Trials  Complex  compliance behavior  Complication  counterscreen  Coupled  design  dorsal horn  Dose-Limiting  drug discovery  Drug Kinetics  Drug Targeting  duloxetine  Dysesthesias  effective therapy  Effectiveness  Esthesia  Feeling  Fiber  G-Protein-Coupled Receptors  Human  improved  In Vitro  in vivo  Indigenous  inhibitor/antagonist  Ion Channel  Laboratories  Lavandula  Lead  Malignant Neoplasms  Mediating  Mediator of activation protein  Medical  Medicinal Plants  meetings  Modeling  Muscle relaxants  Natural Products  Neuraxis  neuronal excitability  Neurons  Neuropathy  neurotoxic  neurotoxicity  neurotransmission  non-opioid analgesic  Norepinephrine  novel  novel therapeutics  Numbness  Opiate Addiction  Opioid  opioid misuse  Opioid Receptor  opioid sparing  opioid use  Oral  Paclitaxel  Pain  Pain management  pain model  pain relief  pain signal  painful neuropathy  Paresthesia  Pathogenesis  Pathway interactions  Peripheral  Peripheral Nerves  Peripheral Nervous System  Peripheral Nervous System Diseases  Pharmaceutical Preparations  Pharmacology  Pharmacotherapy  Phase  Plants  Platinum Compounds  preclinical study  Prevalence  Property  Protein Isoforms  Proteins  Quality of life  Rattus  Regimen  Regulation  reuptake  Role  Safety  screening  Sensory  sensory stimulus  Serotonin  Shock  side effect  Site  small molecule  somatosensory  Southwestern United States  Specificity  Spinal  Spinal Cord  Spinal Ganglia  Structure  success  Survival Rate  synaptic function  T-Type Calcium Channels  taxane  Testing  Tissues  Translating  Treatment Protocols  Universities  venlafaxine  Vinca Alkaloids  voltage  Work  
Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats 期刊论文
发表期刊: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 出版年: 2019, 卷号: 26, 期号: 10, 页码: 9966-9980
作者:  Hassan, Iftekhar;  Husain, Fohad Mabood;  Khan, Rais Ahmad;  Ebaid, Hossam;  Ai-Tamimi, Jameel;  Alhazza, Ibrahim M.;  Aman, Shazia;  Ibrahim, Khalid Elfaki
收藏  |  浏览/下载：55/0  |  提交时间：2019/11/29
Zinc oxide  Nanoparticles  Potassium bromate  Toxicity  In vivo  Oxidative stress  
In vivo antimalarial extracts and constituents of Prosopis juliflora (Fabaceae) 期刊论文
发表期刊: JOURNAL OF FUNCTIONAL FOODS. 出版年: 2018, 卷号: 44, 页码: 74-78
作者:  Batista, Ronan;  Santana, Clarissa Cunha;  Azevedo-Santos, Alene Vanessa;  Suarez-Fontes, Ana Marcia;  de Almeida Antunes Ferraz, Jose Lucas;  Mattos Silva, Luiz Alberto;  Vannier-Santos, Marcos Andre
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/29
Prosopis juliflora  Fabaceae  Juliprosopine  Julifloridine  Plasmodium  In vivo antimalarial activity  
Morphological characterisation of the mycorrhizal symbiosis between Tuberaria guttata (L.) Fourr and Terfezia arenaria (Moris) Trappe 期刊论文
发表期刊: SYMBIOSIS. 出版年: 2018, 卷号: 75, 期号: 2, 页码: 149-154
作者:  Dafri, Ahlem;  Beddiar, Arifa
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/29
Cistaceae  Desert truffles  In vivo culture  Mycorrhiza  Terfezia arenaria  Tuberaria guttata  
A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography 期刊论文
发表期刊: SKIN RESEARCH AND TECHNOLOGY. 出版年: 2018, 卷号: 24, 期号: 3, 页码: 396-406
作者:  Zugaj, D.;  Chenet, A.;  Petit, L.;  Vaglio, J.;  Pascual, T.;  Piketty, C.;  Bourdes, V.
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/29
dynamic optical coherence tomography  image processing workflow  in vivo blood flow detection  laser Doppler imaging  skin vascularization  topical treatment  vessel size distribution  visualization  
A Novel High Biosorbent of Pb-resistant Bacterium Isolate for the Removal of Hazardous Lead from Alkaline Soil and Water: Biosorption Isotherms In Vivo and Bioremediation Strategy 期刊论文
发表期刊: GEOMICROBIOLOGY JOURNAL. 出版年: 2018, 卷号: 35, 期号: 3, 页码: 174-185
作者:  Li, Xiaoping;  Liu, Xianyu;  Bao, Hongxiang;  Wu, Ting;  Zhao, Yanan;  Liu, Dongying;  Li, Xiaoyun;  Yang, Tao;  Yu, Hongtao
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/29
Alkaline soil and water  Bacillus megaterium  bioremediation  biosorption isotherms in vivo  lead