干旱区生态环境知识资源中心(Arid): Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats

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DOI	10.1007/s11356-019-04443-4
	Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats
	Hassan, Iftekhar 1; Husain, Fohad Mabood 2; Khan, Rais Ahmad 3; Ebaid, Hossam 1; Ai-Tamimi, Jameel 1; Alhazza, Ibrahim M.1; Aman, Shazia 4; Ibrahim, Khalid Elfaki 1
通讯作者	Hassan, Iftekhar
来源期刊	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN	0944-1344
EISSN	1614-7499
出版年	2019
卷号	26 期号:10 页码:9966-9980
英文摘要	Potassium bromate (PB) is a commonly used food additive, a prominent water disinfection by-product, and a class IIB carcinogen. It exerts a various degree of toxicity depending on its dose and exposure duration consumed with food and water in the living organisms. The present investigation aims to demonstrate the protective efficacy of zinc oxide nanoparticles (ZnO NPs) derived from Ochradenus arabicus (OA) leaf extract by green technology in PB-challenged Swiss albino rats. The rodents were randomly distributed, under the lab-standardized treatment strategy, into the following six treatment groups: control (group I), PB alone (group II), ZnO alone (group III), ZnO NP alone (group IV), PB + ZnO (group V), and PB + ZnO NPs (group VI). The rats were sacrificed after completion of the treatment, and their blood and liver samples were collected for further analysis. Group II showed extensive toxic effects with altered liver function markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transferase, glutathione-S-transferase, and thioredoxin reductase) and compromised redox status (SOD, CAT, GR, GPx, GSH, MDA, and total carbonyl content). The histopathological analysis and comet assay further supported the biochemical results of the same group. Besides, group III also showed moderate toxicity evidenced by an alteration in most of the studied parameters while group IV demonstrated mild toxicity after biochemical analysis indicating the excellent biocompatibility of the NPs. However, group VI exhibited attenuation of the PB-induced toxic insults to a significant level as compared to group II, whereas group V failed to show similar improvement in the studied parameters. All these findings entail that the ZnO NPs prepared by green synthesis have significant ameliorative property against PB-induced toxicity in vivo. Moreover, administration of the NPs improved the overall health of the treated animals profoundly. Hence, these NPs have significant therapeutic potential against the toxic effects of PB and similar compounds in vivo, and they are suitable to be used at the clinical and industrial levels.
英文关键词	Zinc oxide Nanoparticles Potassium bromate Toxicity In vivo Oxidative stress
类型	Article
语种	英语
国家	Saudi Arabia ; India
收录类别	SCI-E
WOS记录号	WOS:000464852200049
WOS关键词	ZNO NANOPARTICLES ; OXIDATIVE STRESS ; INDUCE APOPTOSIS ; PROTECTIVE ROLE ; DESERT PLANTS ; DNA-DAMAGE ; IDENTIFICATION ; GLUTATHIONE ; TRANSITION ; EXPRESSION
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
来源机构	King Saud University
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/215539
作者单位	1.King Saud Univ, Coll Sci, Dept Zool, Bldg 05, Riyadh 11451, Saudi Arabia; 2.King Saud Univ, Dept Food Sci & Nutr, Coll Food & Agr, Riyadh 11451, Saudi Arabia; 3.King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia; 4.Aligarh Muslim Univ, JN Med Coll & Hosp, Dept Biochem, Aligarh 202002, Uttar Pradesh, India
推荐引用方式 GB/T 7714	Hassan, Iftekhar,Husain, Fohad Mabood,Khan, Rais Ahmad,et al. Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats[J]. King Saud University,2019,26(10):9966-9980.
APA	Hassan, Iftekhar.,Husain, Fohad Mabood.,Khan, Rais Ahmad.,Ebaid, Hossam.,Ai-Tamimi, Jameel.,...&Ibrahim, Khalid Elfaki.(2019).Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,26(10),9966-9980.
MLA	Hassan, Iftekhar,et al."Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 26.10(2019):9966-9980.