Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1111/srt.12442 |
A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography | |
Zugaj, D.; Chenet, A.; Petit, L.; Vaglio, J.; Pascual, T.; Piketty, C.; Bourdes, V. | |
来源期刊 | SKIN RESEARCH AND TECHNOLOGY
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ISSN | 0909-752X |
EISSN | 1600-0846 |
出版年 | 2018 |
卷号 | 24期号:3页码:396-406 |
英文摘要 | Background: Currently, imaging technologies that can accurately assess or provide surrogate markers of the human cutaneous microvessel network are limited. Dynamic optical coherence tomography (D-OCT) allows the detection of blood flow in vivo and visualization of the skin microvasculature. However, image processing is necessary to correct images, filter artifacts, and exclude irrelevant signals. The objective of this study was to develop a novel image processing workflow to enhance the technical capabilities of D-OCT. Materials and methods: Single-center, vehicle-controlled study including healthy vol- unteers aged 18-50 years. A capsaicin solution was applied topically on the subject’s forearm to induce local inflammation. Measurements of capsaicin-induced increase in dermal blood flow, within the region of interest, were performed by laser Doppler imaging (LDI) (reference method) and D-OCT. Results: Sixteen subjects were enrolled. A good correlation was shown between D-OCT and LDI, using the image processing workflow. Therefore, D-OCT offers an easy-to-use alternative to LDI, with good repeatability, new robust morphological features (dermal-epidermal junction localization), and quantification of the distribution of vessel size and changes in this distribution induced by capsaicin. The visualization of the vessel network was improved through bloc filtering arid artifact removal. Moreover, the assessment of vessel size distribution allows a fine analysis of the vascular patterns. Conclusion: The newly developed image processing workflow enhances the technical capabilities of D-OCT for the accurate detection and characterization of microcirculation in the skin. A direct clinical application of this image processing workflow is the quantification of the effect of topical treatment on skin vascularization. |
英文关键词 | dynamic optical coherence tomography image processing workflow in vivo blood flow detection laser Doppler imaging skin vascularization topical treatment vessel size distribution visualization |
类型 | Article |
语种 | 英语 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438221100008 |
WOS关键词 | DERMATOLOGY ; MICROCIRCULATION |
WOS类目 | Dermatology |
WOS研究方向 | Dermatology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/213166 |
推荐引用方式 GB/T 7714 | Zugaj, D.,Chenet, A.,Petit, L.,et al. A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography[J],2018,24(3):396-406. |
APA | Zugaj, D..,Chenet, A..,Petit, L..,Vaglio, J..,Pascual, T..,...&Bourdes, V..(2018).A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography.SKIN RESEARCH AND TECHNOLOGY,24(3),396-406. |
MLA | Zugaj, D.,et al."A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography".SKIN RESEARCH AND TECHNOLOGY 24.3(2018):396-406. |
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