Arid
DOI10.1111/srt.12442
A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography
Zugaj, D.; Chenet, A.; Petit, L.; Vaglio, J.; Pascual, T.; Piketty, C.; Bourdes, V.
来源期刊SKIN RESEARCH AND TECHNOLOGY
ISSN0909-752X
EISSN1600-0846
出版年2018
卷号24期号:3页码:396-406
英文摘要

Background: Currently, imaging technologies that can accurately assess or provide surrogate markers of the human cutaneous microvessel network are limited. Dynamic optical coherence tomography (D-OCT) allows the detection of blood flow in vivo and visualization of the skin microvasculature. However, image processing is necessary to correct images, filter artifacts, and exclude irrelevant signals. The objective of this study was to develop a novel image processing workflow to enhance the technical capabilities of D-OCT.


Materials and methods: Single-center, vehicle-controlled study including healthy vol- unteers aged 18-50 years. A capsaicin solution was applied topically on the subject’s forearm to induce local inflammation. Measurements of capsaicin-induced increase in dermal blood flow, within the region of interest, were performed by laser Doppler imaging (LDI) (reference method) and D-OCT.


Results: Sixteen subjects were enrolled. A good correlation was shown between D-OCT and LDI, using the image processing workflow. Therefore, D-OCT offers an easy-to-use alternative to LDI, with good repeatability, new robust morphological features (dermal-epidermal junction localization), and quantification of the distribution of vessel size and changes in this distribution induced by capsaicin. The visualization of the vessel network was improved through bloc filtering arid artifact removal. Moreover, the assessment of vessel size distribution allows a fine analysis of the vascular patterns.


Conclusion: The newly developed image processing workflow enhances the technical capabilities of D-OCT for the accurate detection and characterization of microcirculation in the skin. A direct clinical application of this image processing workflow is the quantification of the effect of topical treatment on skin vascularization.


英文关键词dynamic optical coherence tomography image processing workflow in vivo blood flow detection laser Doppler imaging skin vascularization topical treatment vessel size distribution visualization
类型Article
语种英语
收录类别SCI-E
WOS记录号WOS:000438221100008
WOS关键词DERMATOLOGY ; MICROCIRCULATION
WOS类目Dermatology
WOS研究方向Dermatology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/213166
推荐引用方式
GB/T 7714
Zugaj, D.,Chenet, A.,Petit, L.,et al. A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography[J],2018,24(3):396-406.
APA Zugaj, D..,Chenet, A..,Petit, L..,Vaglio, J..,Pascual, T..,...&Bourdes, V..(2018).A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography.SKIN RESEARCH AND TECHNOLOGY,24(3),396-406.
MLA Zugaj, D.,et al."A novel image processing workflow for the in vivo quantification of skin microvasculature using dynamic optical coherence tomography".SKIN RESEARCH AND TECHNOLOGY 24.3(2018):396-406.
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