中文版 | English
Arid
项目编号1R21AI149015-01
Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis
HUNG, CHIUNG YU
主持机构UNIVERSITY OF TEXAS SAN ANTONIO
开始日期2020
结束日期2021
资助经费182668(USD)
项目类别Non-SBIR/STTR RPGs
资助机构US-NIH（美国国立卫生研究院）
语种英语
国家美国
英文简介Project Narrative Coccidioides infection, which can lead to disseminated manifestation and potential lethal meningitis, affects residents in the southwestern United States and accounts for 17-29% of community-acquired pneumonia in the endemic areas. Patents received long-term treatment with clinical antifungals against coccidioidomycosis often suffer severe adverse effects, suggesting an urgently unmet need to identify new and better antifungals against this disease. We propose to screen well characterized drug libraries using an imaging flow cytometry based assays and characterize the hits that can be repurposed for treating coccidioidomycosis.
英文关键词acute infection Adverse effects Affect Americas Amphotericin B Animals Antifungal Agents Antimicrobial Resistance Area base Biological Assay Caliber Caspofungin Cell Membrane Permeability Cell Wall Cells chemotherapy Clinical Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Communities Containment Contracts cost Cryptococcus Cryptococcus neoformans Cytochrome P450 Cytology cytotoxicity Data Databases desert fever Development Diagnosis Disease Dose drug development Drug usage drug use screening Flow Cytometry Fluconazole follow-up fungus Goals Government Growth Hand Human Hyphae Image In Vitro in vivo Incubated indexing Infection Inhalation insight Lead Legal patent Libraries Life Cycle Stages Lower respiratory tract structure Lung Lung diseases Medical Medical Research Meningitis Methods Mexico Microscope Morphology Motivation Mycoses Neuraxis novel novel strategies novel therapeutics off-patent pathogen pathogenic fungus Patients Pharmaceutical Preparations Pharmacology Phase IV Clinical Trials Phenotype Pneumonia preclinical development prevent Process Property Reporting Reproduction spores Research Personnel resistant strain Resolution screening small molecule libraries Soil South America Southwestern United States Speed success Symptoms synergism Techniques Testing The science of Mycology Time Toxic effect United States United States National Institutes of Health Vaccines
URL149015
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/356175
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GB/T 7714		 HUNG, CHIUNG YU.Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis.2020.
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