中文版 | English
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项目编号1R01AI148561-01
Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum
RAPPLEYE, CHAD A
主持机构OHIO STATE UNIVERSITY
开始日期2020
结束日期2025
资助经费389949(USD)
项目类别Non-SBIR/STTR RPGs
资助机构US-NIH（美国国立卫生研究院）
语种英语
国家美国
英文简介PROJECT NARRATIVE The fungal pathogen Histoplasma capsulatum causes respiratory and systemic disease by invading and replicating within host cells. Within this host cell, Histoplasma capsulatum scavenges host molecules for its own proliferation during infection, yet these nutritional sources are unknown. This proposal will identify the host molecules consumed by Histoplasma capsulatum when it infects host cells, revealing new therapeutic targets to interfere with the pathogen?s ability to gain metabolic resources from the host.
英文关键词Address alpha ketoglutarate Amino Acid Permease Amino Acid Transporter Amino Acids Attenuated base Carbon Catabolism Cells Citric Acid Cycle Coccidioidomycosis Complement Consumption Data desert fever Diagnosis Disease Environment Enzymes Funding Opportunities fungus Genes Genetic Genetic Screening Genetic screening method Genetic Transcription Genus Hippocampus Gluconeogenesis Glutamate Dehydrogenase Glutamates Glycolysis Goals Growth Histoplasma Histoplasma capsulatum Histoplasmosis Immune system Immunocompetent Immunocompromised Host Impairment In Vitro in vivo Individual Infection Innate Immune System interdisciplinary approach Invaded Investigation Isotope Labeling Lung Lung diseases macrophage Measurement Metabolic Metabolic Pathway metabolic profile Metabolism metabolomics Mitochondria Molecular Molecular Biology Molecular Genetics mouse model mutant Mutation Mycoses new therapeutic target novel strategies novel therapeutics Nutrient Nutritional Nutritional Requirements parasitism pathogen Pathogenesis pathogenic fungus Pathway interactions Peptides Phagocytes Phagosomes prevent Proliferating Reaction residence Resources Respiration response RNA Interference Saccharomyces cerevisiae Source Substrate Specificity Systemic disease Testing Therapeutic Time transcriptomics uptake Virulence Yeasts
URL148561
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/356178
推荐引用方式
GB/T 7714		 RAPPLEYE, CHAD A.Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum.2020.
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