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Short-term perfluorooctane sulfonate exposure impairs Leydig cell regeneration in the adult rat testis via targeting hedgehog signaling 期刊论文
发表期刊: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 出版年: 2021, 卷号: 214
作者:  Mao, Baiping;  Li, Chao;  Wen, Zina;  Li, Huitao;  Wang, Yiyan;  Chen, Lanlan;  Lian, Qingquan;  Ge, Ren-Shan
收藏  |  浏览/下载:53/0  |  提交时间:2021/07/30
Leydig cells  Leydig cell regeneration  Perfluorooctane sulfonate  Stem cells  Steroidogenesis  Hedgehog signaling  
Single-Cell Proteomic Analysis Dissects the Complexity of Tumor Microenvironment in Muscle Invasive Bladder Cancer 期刊论文
发表期刊: CANCERS. 出版年: 2021, 卷号: 13, 期号: 21
作者:  Feng, Chao;  Wang, Xi;  Tao, Yuting;  Xie, Yuanliang;  Lai, Zhiyong;  Li, Zhijian;  Hu, Jiaxin;  Tang, Shaomei;  Pan, Lixin;  He, Liangyu;  Wang, Qiuyan;  Li, Tianyu;  Mo, Zengnan
收藏  |  浏览/下载:35/0  |  提交时间:2022/02/12
muscle invasive bladder cancer  tumor microenvironment  cancer stem cell  mass cytometry  imaging mass cytometry  
MDIBL Symposium on Stem Cells and Aging 项目
项目编号: 1R13AG069520-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2023
负责人:  DRUMMOND, IAIN A. (contact);  ROGERS, ARIC N
收藏  |  浏览/下载:51/0  |  提交时间:2021/08/12
Address  Age  aged  Aging  Animals  Area  Atmosphere  base  Biological  Biology  Blood Cells  Brain  Caloric Restriction  career  Cell Aging  Cell Communication  cell regeneration  Cells  Cellular Metabolic Process  Collaborations  Communities  comparative  Discipline  DNA Damage  Engineering  Epigenetic Process  Equilibrium  Faculty  Failure  Fishes  fly  Generations  Genetic Transcription  graduate student  Human  Immersion  Inflammation  Inflammatory  Injury  innovation  Island  Knowledge  Laboratories  Longevity  Lung  Maine  Maintenance  Medical center  meetings  Mus  Muscle  Mutation  Natural regeneration  novel strategies  Organ  Organ failure  Outcome  Pathology  Postdoctoral Fellow  posters  programs  regenerative  Rejuvenation  Research  Research Institute  Research Personnel  research study  Scientific Advances and Accomplishments  Scientist  Series  Signal Transduction  Skin  stem cell niche  Stem Cell Research  stem cells  symposium  System  The Jackson Laboratory  tissue regeneration  Tissues  tissue stem cells  Training  
Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche 期刊论文
发表期刊: STEM CELLS. 出版年: 2019, 卷号: 37, 期号: 9, 页码: 1238-1248
作者:  Binder, Martin;  Chmielarz, Piotr;  Mckinnon, Peter J.;  Biggs, Leah C.;  Thesleff, Irma;  Balic, Anamaria
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/29
Tooth epithelial stem cells  Stem cell niche  Cervical loop  Hedgehog  Patched  
Project 2 - Macrophage regulation of fibrosis and scarring during tissue regeneration 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2019-
负责人:  GODWIN, JAMES W
收藏  |  浏览/下载:29/0  |  提交时间:2021/08/12
Address  Adult  Aging  Animal Model  Antigens  Biological Assay  Biological Models  Brain  Carbohydrates  Cell Proliferation  cell type  Cells  cellular targeting  Cessation of life  Cicatrix  Comparative Biology  Complex  crosslink  Development  Disease  Enzymes  Epithelial  Epithelial Cells  Epithelium  Exposure to  Extracellular Matrix  Fibroblasts  Fibrosis  Gene Expression  Gene Expression Profile  Genes  Goals  healing  Healthcare  Heart  Human  human tissue  Immune  Infection  Infiltration  Injury  Innate Immune System  innovation  insight  Label  Laboratories  Leukocytes  limb amputation  limb regeneration  Limb structure  Liver  Lung  macrophage  Mammals  Measures  Mediating  Mesenchymal  Methods  Modernization  Molecular  Myofibroblast  Natural regeneration  novel  Operative Surgical Procedures  Organ  overexpression  Patients  Pattern  Pharmacology  Phenotype  Play  prevent  Process  progenitor  programs  Protein-Lysine 6-Oxidase  Proteins  PTPRC gene  Recovery of Function  regenerative  regenerative therapy  Regulation  repaired  RNA Interference  Role  Salamander  Signal Pathway  Signal Transduction  Site  Source  Spinal Cord  Stem cells  Surface  Testing  therapy development  Time  time use  tissue regeneration  tissue repair  Tissues  tool  transcriptome sequencing  transdifferentiation  Traumatic injury  wound  Wound Healing  
Project 1 - Disruption of CpG island-mediated gene regulation and chromatin architecture in progeria and aging 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2019-
负责人:  BECK, SAMUEL
收藏  |  浏览/下载:25/0  |  提交时间:2021/08/12
Address  Age of Onset  age related  Aging  Architecture  Atherosclerosis  Biological  Biology of Aging  Biomedical Research  Blindness  Cardiac Myocytes  Cell Differentiation process  Cells  Chromatin  Chromosome Mapping  Comparative Biology  CpG Islands  CRISPR/Cas technology  Cytosine  Data Set  de novo mutation  Defect  Degenerative Disorder  Dinucleoside Phosphates  Disease  DNA  DNA Damage  DNA Repair  Economics  Elements  epigenetic regulation  Euchromatin  Fatty Liver  Fluorescent in Situ Hybridization  Frequencies  Gene Expression  Gene Expression Regulation  Genes  Genetic  Genetic Transcription  genome editing  genome-wide  Genomic Instability  Goals  Guanine  Hair  Hepatocyte  Heterochromatin  Impairment  induced pluripotent stem cell  innovation  inorganic phosphate  insight  Lamin Type A  Lamins  Life  Life Expectancy  Link  Mediating  Meta-Analysis  Modeling  Molecular  Morphology  mRNA sequencing  Musculoskeletal  Mutation  Natural regeneration  Nuclear  Nuclear Lamin  Nuclear Lamina  Pathology  Patients  Peripheral  Physiological  Predisposition  prevent  Process  Progeria  promoter  Property  Proteins  Psyche structure  Public Health  Regulation  Resources  response  restoration  Skin  Structural Protein  Symptoms  Testing  therapy development  tissue repair  Tissues  Undifferentiated  
Combination therapy of autologous adipose mesenchymal stem cell-enriched, high-density lipoaspirate and topical timolol for healing chronic wounds 期刊论文
发表期刊: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 出版年: 2018, 卷号: 12, 期号: 1, 页码: 186-190
作者:  Larsen, Larissa;  Tchanque-Fossuo, Catherine N.;  Gorouhi, Farzam;  Boudreault, David;  Chuong Nguyen;  Fuentes, Jaime J.;  Crawford, Robert W.;  Dahle, Sara E.;  Whetzel, Thomas;  Isseroff, R. Rivkah
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/29
autologous adipose mesenchymal stem cell  high-density lipoaspirate  timolol  venous leg ulcer  wound healing  
Understanding germ cell pluripotency through an inducible P-granule degradation system 项目
项目编号: 5F32GM128248-02. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2018-2020
负责人:  MARNIK, ELISABETH ADKINS
收藏  |  浏览/下载:15/0  |  提交时间:2021/08/12
Adult  Animals  Auxins  base  Biological Assay  Caenorhabditis elegans  Cell Nucleus  Cell Proliferation  cell type  Clustered Regularly Interspaced Short Palindromic Repeats  Complex  CRISPR/Cas technology  Cytoplasm  Cytoplasmic Granules  Data  Development  Engineering  Exposure to  Fertility  Generations  Genes  Germ  Germ Cells  Goals  Human  Imagery  in vivo  Inherited  innovation  insight  Long-Term Effects  Malignant Neoplasms  Messenger RNA  Morphology  mRNA Expression  mRNA sequencing  Muscle  Neurites  neuronal cell body  Neurons  Oocytes  Organism  pluripotency  Postdoctoral Fellow  premature  prevent  Process  protein degradation  Proteins  rapid technique  regenerative  Regulation  Reporter  Research  Research Personnel  Ribonucleoproteins  RNA Interference  safety net  sperm cell  Stem cells  Sterility  System  Techniques  Testing  Therapeutic  Time  Transcript  Translations  Work  young adult  
Understanding germ cell pluripotency through an inducible P-granule degradation system 项目
项目编号: 1F32GM128248-01A1. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2018-2020
负责人:  MARNIK, ELISABETH ADKINS
收藏  |  浏览/下载:16/0  |  提交时间:2021/08/12
Genetics  Stem Cell Research  Stem Cell Research - Nonembryonic - Non-Human  
Leydig cell stem cells: Identification, proliferation and differentiation 期刊论文
发表期刊: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 出版年: 2017, 卷号: 445, 期号: C, 页码: 65-73
作者:  Chen, Haolin;  Wang, Yiyan;  Ge, Renshan;  Zirkin, Barry R.
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/29
Leydig cell  Stem cell  DHH  CD90  COUP-TFII