中文版 | English
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项目编号5F32GM128248-02
Understanding germ cell pluripotency through an inducible P-granule degradation system
MARNIK, ELISABETH ADKINS
主持机构MOUNT DESERT ISLAND BIOLOGICAL LAB
开始日期2018
结束日期2020
资助经费64322(USD)
项目类别TRAINING, INDIVIDUAL
资助机构US-NIH（美国国立卫生研究院）
语种英语
国家美国
英文简介Project Narrative: Unlocking how cellular pluripotency is maintained is a critical first step in enabling researchers to induce pluripotency when needed, or stop pluripotency when it is harmful. This proposed project seeks to study germ granules, known as P granules in C.elegans, which are cytoplasmic factors critical in maintaining germline pluripotency. Understanding how P granules carry out this function will provide new insight into the cytoplasmic regulation of pluripotency, and how it may be used to induce or control pluripotency in higher organisms.
英文关键词Adult Animals Auxins base Biological Assay Caenorhabditis elegans Cell Nucleus Cell Proliferation cell type Clustered Regularly Interspaced Short Palindromic Repeats Complex CRISPR/Cas technology Cytoplasm Cytoplasmic Granules Data Development Engineering Exposure to Fertility Generations Genes Germ Germ Cells Goals Human Imagery in vivo Inherited innovation insight Long-Term Effects Malignant Neoplasms Messenger RNA Morphology mRNA Expression mRNA sequencing Muscle Neurites neuronal cell body Neurons Oocytes Organism pluripotency Postdoctoral Fellow premature prevent Process protein degradation Proteins rapid technique regenerative Regulation Reporter Research Research Personnel Ribonucleoproteins RNA Interference safety net sperm cell Stem cells Sterility System Techniques Testing Therapeutic Time Transcript Translations Work young adult
URL128248
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/356170
推荐引用方式
GB/T 7714		 MARNIK, ELISABETH ADKINS.Understanding germ cell pluripotency through an inducible P-granule degradation system.2018.
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