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Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer 期刊论文
发表期刊: JOURNAL OF PATHOLOGY. 出版年: 2021
作者:  Backman, Max;  La Fleur, Linnea;  Kurppa, Pinja;  Djureinovic, Dijana;  Elfving, Hedvig;  Brunnstrom, Hans;  Mattsson, Johanna Sofia Margareta;  Lindberg, Amanda;  Ponten, Victor;  Eltahir, Mohamed;  Mangsbo, Sara;  Gulyas, Miklos;  Isaksson, Johan;  Jirstrom, Karin;  Karre, Klas;  Leandersson, Karin;  Mezheyeuski, Artur;  Ponten, Fredrik;  Strell, Carina;  Lindskog, Cecilia;  Botling, Johan;  Micke, Patrick
收藏  |  浏览/下载:56/0  |  提交时间:2021/11/19
immune cell infiltration  PD-L1  checkpoint therapy  tumor microenvironment  lung cancer  NSCLC  p53  
Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2019-2020
负责人:  KHANNA, RAJESH
收藏  |  浏览/下载:36/0  |  提交时间:2021/08/12
Absence of pain sensation  addiction  Affect  Afferent Neurons  American  Amitriptyline  Analgesics  analog  Antidepressive Agents  Arizona  Axon  Baclofen  base  Betulinic Acid  Biological Assay  biophysical properties  Calcium  Calcium Channel Blockers  Calcium Channel Inhibition  cancer pain  Cancer Patient  cancer survival  cancer therapy  Cell-Mediated Cytolysis  Cells  central sensitization  chemotherapeutic agent  chemotherapy  Chemotherapy-induced peripheral neuropathy  Chemotherapy-Oncologic Procedure  Chronic  chronic pain  chronic pain relief  chronic painful condition  Clinical  Clinical Trials  Complex  compliance behavior  Complication  counterscreen  Coupled  design  dorsal horn  Dose-Limiting  drug discovery  Drug Kinetics  Drug Targeting  duloxetine  Dysesthesias  effective therapy  Effectiveness  Esthesia  Feeling  Fiber  G-Protein-Coupled Receptors  Human  improved  In Vitro  in vivo  Indigenous  inhibitor/antagonist  Ion Channel  Laboratories  Lavandula  Lead  Malignant Neoplasms  Mediating  Mediator of activation protein  Medical  Medicinal Plants  meetings  Modeling  Muscle relaxants  Natural Products  Neuraxis  neuronal excitability  Neurons  Neuropathy  neurotoxic  neurotoxicity  neurotransmission  non-opioid analgesic  Norepinephrine  novel  novel therapeutics  Numbness  Opiate Addiction  Opioid  opioid misuse  Opioid Receptor  opioid sparing  opioid use  Oral  Paclitaxel  Pain  Pain management  pain model  pain relief  pain signal  painful neuropathy  Paresthesia  Pathogenesis  Pathway interactions  Peripheral  Peripheral Nerves  Peripheral Nervous System  Peripheral Nervous System Diseases  Pharmaceutical Preparations  Pharmacology  Pharmacotherapy  Phase  Plants  Platinum Compounds  preclinical study  Prevalence  Property  Protein Isoforms  Proteins  Quality of life  Rattus  Regimen  Regulation  reuptake  Role  Safety  screening  Sensory  sensory stimulus  Serotonin  Shock  side effect  Site  small molecule  somatosensory  Southwestern United States  Specificity  Spinal  Spinal Cord  Spinal Ganglia  Structure  success  Survival Rate  synaptic function  T-Type Calcium Channels  taxane  Testing  Tissues  Translating  Treatment Protocols  Universities  venlafaxine  Vinca Alkaloids  voltage  Work  
Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis 项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2018-2020
负责人:  BAKER, BILL J;  CHAIN, PATRICK S. G.;  MURRAY, ALISON ELIZABETH (contact)
收藏  |  浏览/下载:21/0  |  提交时间:2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A  Anabolism  Antarctic  Architecture  ascidian  Atmosphere  Bacteria  Bacterial Genome  base  Base Sequence  Bioinformatics  cancer therapy  candidate validation  cell growth  Cell Line  cell type  Cells  chemotherapeutic agent  chemotherapy  Clinical  Code  contig  Cytostatics  cytotoxicity  Data  Development  Diagnosis  Disease  drug development  Drug Targeting  fighting  Gene Cluster  Genes  genetic manipulation  Genome  Genome Mappings  genome sequencing  Genomics  Goals  Harvest  High-Risk Cancer  Human Cell Line  Hybrids  Immunotherapy  In Vitro  indexing  insight  interest  Ligase  Macrolides  Marines  markov model  Melanins  melanocyte  melanoma  Melanoma Cell  metagenome  metagenomic sequencing  Metastatic Melanoma  microbial  microbiome  microorganism  Mining  Modeling  Molecular  Mutagenesis  Natural Products  New Agents  next generation  novel  Organism  Outcomes Research  Pathway interactions  peptide synthase  Pharmaceutical Preparations  Pharmacology  polyketide synthase  Preparation  Procedures  Production  Proton Pump  reference genome  Research  research and development  Resistance  Resistance development  Ribosomal RNA  Risk  scale up  screening  Signal Transduction Pathway  Skin  Skin Cancer  Source  Specificity  Specimen  stratospheric ozone  Structure  Survival Rate  symbiont  System  targeted agent  Therapeutic  tool  Toxic effect  Treatment Efficacy  tumor  Ultraviolet Rays  United States  vacuolar H+-ATPase  whole genome  
Targeting Tumor Oct4 to Deplete Prostate Tumor and Metastasis Initiating Cells. 科技报告
报告编号: AD1049890. 出版年: 2017
作者:  Nie, D.
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/30
Prostate cancer  Neoplasms  Gene expression  Genetics  Amino acids  Cell line  Metastasis  Epithelial cells  Cell nucleus  Stem cells  Chromosomes  Cell physiological processes  Therapy  Oct4  Cancer stem cells  Tumor formation  
Androgen receptor and miR-206 regulation in prostate cancer 期刊论文
发表期刊: TRANSCRIPTION-AUSTIN. 出版年: 2017, 卷号: 8, 期号: 5, 页码: 313-327
作者:  Chua, Fu Y.;  Adams, Brian D.
收藏  |  浏览/下载:9/0  |  提交时间:2021/01/08
androgen receptor  biomarker  microRNA  miR-206  prostate cancer  therapy  treatment resistance  tumor suppressor  
Hedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas 期刊论文
发表期刊: FUTURE ONCOLOGY. 出版年: 2015, 卷号: 11, 期号: 22, 页码: 2997-3002
作者:  Pierard-Franchimont, Claudine;  Hermanns-Le, Trinh;  Paquet, Philippe;  Herfs, Michael;  Delvenne, Philippe;  Pierard, Gerald E.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/29
basal cell carcinoma  cancer stem cell  cyclopamine  cytotoxic chemotherapy  Desert Hedgehog  EGF  everolimus  Hedgehog  hereditary basal cell nevus syndrome  Indian Hedgehog  itraconazole  metastasis  NF-B  protein kinase  PTCH1  SMO  Sonic Hedgehog  TGF  therapy resistance  vismodegib  
Post-docetaxel therapy in castration resistant prostate cancer - the forest is growing in the desert 期刊论文
发表期刊: THERAPEUTIC ADVANCES IN UROLOGY. 出版年: 2012, 卷号: 4, 期号: 3, 页码: 107-111
作者:  Altavilla, Amelia;  Iacovelli, Roberto;  Procopio, Giuseppe;  Cortesi, Enrico
收藏  |  浏览/下载:10/0  |  提交时间:2021/01/08
castration resistant  prostate cancer  abiraterone  cabazitaxel  chemotherapy  hormonal therapy  sipuleucel-T  docetaxel  
Putting cancer into words: Stories as medicine for women attending the Healing Journeys conference 学位论文
学位授予机构: Institute of Transpersonal Psychology. 出版年: 2008
作者:  Caldwell, Philipa Ann Redlich
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/29
Cancer  Ethnography  Healing Journeys  Narrative therapy  PTSD  Stories  Transformation  Women  Women's health  
Hedgehog signalling in foregut malignancy 期刊论文
发表期刊: BIOCHEMICAL PHARMACOLOGY. 出版年: 2004, 卷号: 68, 期号: 6, 页码: 1055-1060
作者:  Watkins, DN;  Peacock, CD
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/28
hedgehog  cancer  foregut  stem cell  therapy  cyclopamine  
Hedgehog signalling in foregut malignancy 会议论文
会议名称: Conference on Signal Transduction and Chromatin. 会议地点: Kirchberg, LUXEMBOURG. 会议日期: JAN 26-31, 2004
作者:  Watkins, DN;  Peacock, CD
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/07
hedgehog  cancer  foregut  stem cell  therapy  cyclopamine