干旱区生态环境知识资源中心(Arid): Androgen receptor and miR-206 regulation in prostate cancer

Arid

DOI	10.1080/21541264.2017.1322668
	Androgen receptor and miR-206 regulation in prostate cancer
	Chua, Fu Y.; Adams, Brian D.
通讯作者	Adams, BD
来源期刊	TRANSCRIPTION-AUSTIN
ISSN	2154-1264
EISSN	2154-1272
出版年	2017
卷号	8 期号:5 页码:313-327
英文摘要	In the United States, prostate cancer is the second leading cause of cancer-related deaths among men with an approximately 220,000 patients diagnosed with the disease in 2015. Prostate cancer is a hormone-driven tumor, and a common therapy is androgen-deprivation therapy (ADT) that involves anti-androgen treatments and/or castration therapy. Understanding the molecular basis for androgen-independent tumors is crucial toward developing new therapies for these patients. Understanding how androgen receptor itself functions is an important step in elucidating this process. Androgen receptor (AR), NR3C4, is a nuclear hormone receptor and functions as a DNA-binding transcription factor that regulates the expression of protein-coding genes. Translocation of AR to improper gene promoter elements or DNA-binding sites can result in an alteration in gene expression and thus normal prostate function. Therefore, it is crucial to understand which AR-promoter interactions are drivers of disease, as compared to promiscuous or benign AR-binding interactions. While a large portion of our genome is considered a gene desert, it is now appreciated that these regions of the genome contain non-coding RNA genes such as microRNAs (miRNAs). These non-coding RNAs have enormous regulatory potential, as they post-transcriptionally regulate gene expression by binding to messenger RNAs (mRNAs) to promote degradation or intervention of translational processes. In this review, we focus specifically on the notion that mis-regulation of non-coding RNAs such as miRNAs by improper AR-DNA binding are an important component that promotes prostate cancer. We also highlight the role of miR-206 and the interaction of miR-206 and AR within this process, given this is a miRNA known to be regulated by hormones in both breast and prostate cancer.
英文关键词	androgen receptor biomarker microRNA miR-206 prostate cancer therapy treatment resistance tumor suppressor
类型	Review
语种	英语
开放获取类型	Green Published, Bronze
收录类别	ESCI
WOS记录号	WOS:000419880600005
WOS关键词	MUSCLE-SPECIFIC MICRORNA ; ALPHA ER-ALPHA ; NONCODING RNAS ; MESSENGER-RNA ; DNA-BINDING ; TRANSCRIPTIONAL ACTIVATION ; LINEAGE PLASTICITY ; TUMOR-SUPPRESSOR ; TISSUE SPECIMENS ; TARGET GENES
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
Scopus学科分类	SUNY Albany, Res Fac, 1400 Washington Ave, Albany, NY 12222 USA.
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/332484
作者单位	[Chua, Fu Y.] SUNY Albany, Albany, NY 12222 USA; [Chua, Fu Y.; Adams, Brian D.] SUNY Albany, RNA Inst, Albany, NY 12222 USA; [Adams, Brian D.] Yale Univ, Sch Med, Dept Internal Med, 333 Cedar St, New Haven, CT 06510 USA
推荐引用方式 GB/T 7714	Chua, Fu Y.,Adams, Brian D.. Androgen receptor and miR-206 regulation in prostate cancer[J],2017,8(5):313-327.
APA	Chua, Fu Y.,&Adams, Brian D..(2017).Androgen receptor and miR-206 regulation in prostate cancer.TRANSCRIPTION-AUSTIN,8(5),313-327.
MLA	Chua, Fu Y.,et al."Androgen receptor and miR-206 regulation in prostate cancer".TRANSCRIPTION-AUSTIN 8.5(2017):313-327.