干旱区生态环境知识资源中心(Arid): Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis

Arid

项目编号	5R21CA205932-02
	Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis
	BAKER, BILL J; CHAIN, PATRICK S. G.; MURRAY, ALISON ELIZABETH (contact)
主持机构	DESERT RESEARCH INSTITUTE
开始日期	2018
结束日期	2020
资助经费	102042(USD)
项目类别	NON-SBIR/STTR RPGS
资助机构	US-NIH（美国国立卫生研究院）
语种	英语
国家	美国
英文简介	Project Narrative: The proposed research aims to identify a metagenome-encoded biosynthetic gene cluster from symbionts of the Antarctic ascidian, Synoicum adareanum, that is responsible for biosynthesis a potent new class of anti-melanoma targeted natural products, Palmerolides. Palmerolides have high specificity to melanoma cells and offer a new mechanism of action to fight metastatic melanoma.
英文关键词	3-hydroxy-3-methylglutaryl-coenzyme A Anabolism Antarctic Architecture ascidian Atmosphere Bacteria Bacterial Genome base Base Sequence Bioinformatics cancer therapy candidate validation cell growth Cell Line cell type Cells chemotherapeutic agent chemotherapy Clinical Code contig Cytostatics cytotoxicity Data Development Diagnosis Disease drug development Drug Targeting fighting Gene Cluster Genes genetic manipulation Genome Genome Mappings genome sequencing Genomics Goals Harvest High-Risk Cancer Human Cell Line Hybrids Immunotherapy In Vitro indexing insight interest Ligase Macrolides Marines markov model Melanins melanocyte melanoma Melanoma Cell metagenome metagenomic sequencing Metastatic Melanoma microbial microbiome microorganism Mining Modeling Molecular Mutagenesis Natural Products New Agents next generation novel Organism Outcomes Research Pathway interactions peptide synthase Pharmaceutical Preparations Pharmacology polyketide synthase Preparation Procedures Production Proton Pump reference genome Research research and development Resistance Resistance development Ribosomal RNA Risk scale up screening Signal Transduction Pathway Skin Skin Cancer Source Specificity Specimen stratospheric ozone Structure Survival Rate symbiont System targeted agent Therapeutic tool Toxic effect Treatment Efficacy tumor Ultraviolet Rays United States vacuolar H+-ATPase whole genome
URL	205932
资源类型	项目
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/356146
推荐引用方式 GB/T 7714	BAKER, BILL J,CHAIN, PATRICK S. G.,MURRAY, ALISON ELIZABETH .Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis.2018.