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Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis
项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2021
负责人:
HUNG, CHIUNG YU
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/08/12
acute infection
Adverse effects
Affect
Americas
Amphotericin B
Animals
Antifungal Agents
Antimicrobial Resistance
Area
base
Biological Assay
Caliber
Caspofungin
Cell Membrane Permeability
Cell Wall
Cells
chemotherapy
Clinical
Coccidioides
Coccidioides immitis
Coccidioides posadasii
Coccidioidomycosis
Communities
Containment
Contracts
cost
Cryptococcus
Cryptococcus neoformans
Cytochrome P450
Cytology
cytotoxicity
Data
Databases
desert fever
Development
Diagnosis
Disease
Dose
drug development
Drug usage
drug use screening
Flow Cytometry
Fluconazole
follow-up
fungus
Goals
Government
Growth
Hand
Human
Hyphae
Image
In Vitro
in vivo
Incubated
indexing
Infection
Inhalation
insight
Lead
Legal patent
Libraries
Life Cycle Stages
Lower respiratory tract structure
Lung
Lung diseases
Medical
Medical Research
Meningitis
Methods
Mexico
Microscope
Morphology
Motivation
Mycoses
Neuraxis
novel
novel strategies
novel therapeutics
off-patent
pathogen
pathogenic fungus
Patients
Pharmaceutical Preparations
Pharmacology
Phase IV Clinical Trials
Phenotype
Pneumonia
preclinical development
prevent
Process
Property
Reporting
Reproduction spores
Research Personnel
resistant strain
Resolution
screening
small molecule libraries
Soil
South America
Southwestern United States
Speed
success
Symptoms
synergism
Techniques
Testing
The science of Mycology
Time
Toxic effect
United States
United States National Institutes of Health
Vaccines
Regulatory T cell function in predicting Valley fever outcomes
项目
项目编号: 1R21AI142261-01A1. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2022
负责人:
HOYER, KATRINA K.
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/08/12
Activities of Daily Living
Acute
acute infection
adaptive immune response
Adult
Aftercare
Age
Algorithms
Antibiotic Therapy
Antifungal Agents
Area
Arizona
Bacterial Infections
base
Biological Factors
Biological Markers
Blood
California
Case Study
Cell physiology
Cells
Cessation of life
Child
Childhood
Chronic
Chronic Disease
chronic infection
Clinic
Clinical
Coccidioides
Coccidioides immitis
Coccidioides posadasii
Coccidioidomycosis
Contracts
Data
Data Set
desert fever
Detection
Diagnosis
Diagnostic
Disease
Disease Outcome
Dust
eosinophil
Evaluation
experience
flu
Frequencies
fungus
Health
Immune
Immune response
Immunity
Immunologic Factors
Immunologic Markers
Impaired health
improved
Incidence
Infection
Inhalation
Knowledge
Lung nodule
Measurement
Methods
Mexico
Modeling
Monitor
Mus
neutrophil
novel
older patient
Outcome
pathogenic fungus
Patient Care
Patients
pediatric patients
peripheral blood
Pharmaceutical Preparations
Phenotype
Population
prediction algorithm
Predictive Factor
predictive modeling
predictive test
prevent
Recurrent disease
Regulatory T-Lymphocyte
Relapse
research study
Resolution
response
Severities
Severity of illness
side effect
Soil
South America
Southwestern United States
Symptoms
Testing
Time
tool
Translational Research
transmission process
Travel
Vaccines
Washington
Weather
Splice modulatory therapy for valley fever
项目
项目编号: 1R21AI154106-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2022
负责人:
BURKART, MICHAEL D.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/12
Acute Myelocytic Leukemia
Amphotericin B
analog
anti-cancer
Antifungal Agents
Arizona
Azoles
base
Biological
Biological Markers
Biology
California
cancer cell
Cells
Chemicals
Clinical
Coccidioides immitis
Coccidioides posadasii
Coccidioidomycosis
combat
Communities
desert fever
design
Development
Diagnosis
Disease
Drug Interactions
Dust
Evaluation
Event
Family
flu
Fluconazole
Funding
fungus
Future
Genes
Goals
high reward
high risk
Human
Incidence
Individual
Infection
Investigation
Laboratories
Lead
Left
Life
Messenger RNA
Modernization
Natural Products
new therapeutic target
next generation
novel
Oncogenic
Outcome
outcome forecast
Pathway interactions
Patients
Pattern
Pharmaceutical Chemistry
Pharmaceutical Preparations
Play
Pneumonia
Positioning Attribute
Precipitation
preclinical study
Preparation
programs
Reporting
RNA Splicing
scaffold
Seasons
Series
Side
side effect
small molecule
Spliceosomes
Structure
System
Systems Biology
Techniques
Testing
Therapeutic
therapeutic target
tool
transcriptome
transcriptomics
Translating
Translations
United States
Work
Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain
项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2019-2020
负责人:
KHANNA, RAJESH
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/08/12
Absence of pain sensation
addiction
Affect
Afferent Neurons
American
Amitriptyline
Analgesics
analog
Antidepressive Agents
Arizona
Axon
Baclofen
base
Betulinic Acid
Biological Assay
biophysical properties
Calcium
Calcium Channel Blockers
Calcium Channel Inhibition
cancer pain
Cancer Patient
cancer survival
cancer therapy
Cell-Mediated Cytolysis
Cells
central sensitization
chemotherapeutic agent
chemotherapy
Chemotherapy-induced peripheral neuropathy
Chemotherapy-Oncologic Procedure
Chronic
chronic pain
chronic pain relief
chronic painful condition
Clinical
Clinical Trials
Complex
compliance behavior
Complication
counterscreen
Coupled
design
dorsal horn
Dose-Limiting
drug discovery
Drug Kinetics
Drug Targeting
duloxetine
Dysesthesias
effective therapy
Effectiveness
Esthesia
Feeling
Fiber
G-Protein-Coupled Receptors
Human
improved
In Vitro
in vivo
Indigenous
inhibitor/antagonist
Ion Channel
Laboratories
Lavandula
Lead
Malignant Neoplasms
Mediating
Mediator of activation protein
Medical
Medicinal Plants
meetings
Modeling
Muscle relaxants
Natural Products
Neuraxis
neuronal excitability
Neurons
Neuropathy
neurotoxic
neurotoxicity
neurotransmission
non-opioid analgesic
Norepinephrine
novel
novel therapeutics
Numbness
Opiate Addiction
Opioid
opioid misuse
Opioid Receptor
opioid sparing
opioid use
Oral
Paclitaxel
Pain
Pain management
pain model
pain relief
pain signal
painful neuropathy
Paresthesia
Pathogenesis
Pathway interactions
Peripheral
Peripheral Nerves
Peripheral Nervous System
Peripheral Nervous System Diseases
Pharmaceutical Preparations
Pharmacology
Pharmacotherapy
Phase
Plants
Platinum Compounds
preclinical study
Prevalence
Property
Protein Isoforms
Proteins
Quality of life
Rattus
Regimen
Regulation
reuptake
Role
Safety
screening
Sensory
sensory stimulus
Serotonin
Shock
side effect
Site
small molecule
somatosensory
Southwestern United States
Specificity
Spinal
Spinal Cord
Spinal Ganglia
Structure
success
Survival Rate
synaptic function
T-Type Calcium Channels
taxane
Testing
Tissues
Translating
Treatment Protocols
Universities
venlafaxine
Vinca Alkaloids
voltage
Work
Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis
项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2018-2020
负责人:
BAKER, BILL J
;
CHAIN, PATRICK S. G.
;
MURRAY, ALISON ELIZABETH (contact)
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A
Anabolism
Antarctic
Architecture
ascidian
Atmosphere
Bacteria
Bacterial Genome
base
Base Sequence
Bioinformatics
cancer therapy
candidate validation
cell growth
Cell Line
cell type
Cells
chemotherapeutic agent
chemotherapy
Clinical
Code
contig
Cytostatics
cytotoxicity
Data
Development
Diagnosis
Disease
drug development
Drug Targeting
fighting
Gene Cluster
Genes
genetic manipulation
Genome
Genome Mappings
genome sequencing
Genomics
Goals
Harvest
High-Risk Cancer
Human Cell Line
Hybrids
Immunotherapy
In Vitro
indexing
insight
interest
Ligase
Macrolides
Marines
markov model
Melanins
melanocyte
melanoma
Melanoma Cell
metagenome
metagenomic sequencing
Metastatic Melanoma
microbial
microbiome
microorganism
Mining
Modeling
Molecular
Mutagenesis
Natural Products
New Agents
next generation
novel
Organism
Outcomes Research
Pathway interactions
peptide synthase
Pharmaceutical Preparations
Pharmacology
polyketide synthase
Preparation
Procedures
Production
Proton Pump
reference genome
Research
research and development
Resistance
Resistance development
Ribosomal RNA
Risk
scale up
screening
Signal Transduction Pathway
Skin
Skin Cancer
Source
Specificity
Specimen
stratospheric ozone
Structure
Survival Rate
symbiont
System
targeted agent
Therapeutic
tool
Toxic effect
Treatment Efficacy
tumor
Ultraviolet Rays
United States
vacuolar H+-ATPase
whole genome