中文版 | English
Arid
项目编号1R21AI154106-01
Splice modulatory therapy for valley fever
BURKART, MICHAEL D.
主持机构UNIVERSITY OF CALIFORNIA, SAN DIEGO
开始日期2020
结束日期2022
资助经费236250(USD)
项目类别Non-SBIR/STTR RPGs
资助机构US-NIH（美国国立卫生研究院）
语种英语
国家美国
英文简介8. Project Narrative. New strategies are needed to combat the increasing incidence of coccidioidomycosis (Valley Fever). This program explores targeted antifungal agents that act by modulation of splicing events selective to fungal cells. Here, our team adapts medicinal chemistry and chemical biology with modern systems biology and targeted transcriptomics to advance compounds for a new class of next generation anti- coccidioidomycosis treatments.
英文关键词Acute Myelocytic Leukemia Amphotericin B analog anti-cancer Antifungal Agents Arizona Azoles base Biological Biological Markers Biology California cancer cell Cells Chemicals Clinical Coccidioides immitis Coccidioides posadasii Coccidioidomycosis combat Communities desert fever design Development Diagnosis Disease Drug Interactions Dust Evaluation Event Family flu Fluconazole Funding fungus Future Genes Goals high reward high risk Human Incidence Individual Infection Investigation Laboratories Lead Left Life Messenger RNA Modernization Natural Products new therapeutic target next generation novel Oncogenic Outcome outcome forecast Pathway interactions Patients Pattern Pharmaceutical Chemistry Pharmaceutical Preparations Play Pneumonia Positioning Attribute Precipitation preclinical study Preparation programs Reporting RNA Splicing scaffold Seasons Series Side side effect small molecule Spliceosomes Structure System Systems Biology Techniques Testing Therapeutic therapeutic target tool transcriptome transcriptomics Translating Translations United States Work
URL154106
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/356180
推荐引用方式
GB/T 7714		 BURKART, MICHAEL D..Splice modulatory therapy for valley fever.2020.
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