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| Systems-level genetic patterns underlying disseminated coccidioidomycosis in humans 项目
项目编号: 1R21AI152394-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: LUSSIER, YVES A.
  收藏 | 浏览/下载：28/0 | 提交时间：2021/08/12
Acute Address adverse outcome African American Alleles Automobile Driving Biochemical Biological Biological Process Biology bone Brain Candidate Disease Gene Caring Case Study Categories causal variant Chronic Clinical clinical care Coccidioides Coccidioidomycosis Code cohort Communicable Diseases Complex Data Databases desert fever design Disease Disease susceptibility DNA Emerging Communicable Diseases Equilibrium Exogenous Factors exome exome sequencing experience Filipino flu Foundations fungus Gene Expression Gene Mutation Genes Genetic genetic architecture Genetic Heterogeneity Genetic Predisposition to Disease genetic risk factor Genetic Variation genome-wide genome-wide analysis Genotype genotyped patients Guidelines Haplotypes Heterogeneity high risk HLA Antigens Human Human Genetics human leukocyte antigen testing IFNGR1 gene IL12RB1 gene Immune Immune response Immune system Immunocompetent Immunogenetics Immunological Models Immunosuppression Infection Inhalation insight Knowledge Life Lung Medical Modeling Molecular Mutation Mycoses National Institute of Allergy and Infectious Disease novel Organ Participant pathogen pathogen exposure Pathogenesis pathogenic fungus Pathology Pathway Analysis Pathway interactions Patients Pattern Phenotype Play Pneumonia Positioning Attribute Predisposition Proteins Quantitative Trait Loci rare variant Recommendation recruit Resistance Resources response Risk risk variant Role Sample Size Sampling Studies Signal Transduction Skin Soil STAT1 gene STAT3 gene Stimulus Symptoms System Systems Analysis Testing Therapeutic Time Variant whole genome |
| Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum 项目
项目编号: 1R01AI148561-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2025
负责人: RAPPLEYE, CHAD A
收藏 | 浏览/下载：38/0 | 提交时间：2021/08/12
Address alpha ketoglutarate Amino Acid Permease Amino Acid Transporter Amino Acids Attenuated base Carbon Catabolism Cells Citric Acid Cycle Coccidioidomycosis Complement Consumption Data desert fever Diagnosis Disease Environment Enzymes Funding Opportunities fungus Genes Genetic Genetic Screening Genetic screening method Genetic Transcription Genus Hippocampus Gluconeogenesis Glutamate Dehydrogenase Glutamates Glycolysis Goals Growth Histoplasma Histoplasma capsulatum Histoplasmosis Immune system Immunocompetent Immunocompromised Host Impairment In Vitro in vivo Individual Infection Innate Immune System interdisciplinary approach Invaded Investigation Isotope Labeling Lung Lung diseases macrophage Measurement Metabolic Metabolic Pathway metabolic profile Metabolism metabolomics Mitochondria Molecular Molecular Biology Molecular Genetics mouse model mutant Mutation Mycoses new therapeutic target novel strategies novel therapeutics Nutrient Nutritional Nutritional Requirements parasitism pathogen Pathogenesis pathogenic fungus Pathway interactions Peptides Phagocytes Phagosomes prevent Proliferating Reaction residence Resources Respiration response RNA Interference Saccharomyces cerevisiae Source Substrate Specificity Systemic disease Testing Therapeutic Time transcriptomics uptake Virulence Yeasts |
| Brucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection Model 期刊论文
发表期刊: INFECTION AND IMMUNITY. 出版年: 2019, 卷号: 87, 期号: 1
作者: Kang, Yoon-Suk; Brown, Daniel A.; Kirby, James E.
收藏 | 浏览/下载：17/0 | 提交时间：2019/11/29
Brucella Brucella neotomae brucellosis bioluminescent imaging murine model pathogenesis pathology type IV secretion system undulant fever |
| Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人: KHANNA, RAJESH
收藏 | 浏览/下载：37/0 | 提交时间：2021/08/12
Absence of pain sensation addiction Affect Afferent Neurons American Amitriptyline Analgesics analog Antidepressive Agents Arizona Axon Baclofen base Betulinic Acid Biological Assay biophysical properties Calcium Calcium Channel Blockers Calcium Channel Inhibition cancer pain Cancer Patient cancer survival cancer therapy Cell-Mediated Cytolysis Cells central sensitization chemotherapeutic agent chemotherapy Chemotherapy-induced peripheral neuropathy Chemotherapy-Oncologic Procedure Chronic chronic pain chronic pain relief chronic painful condition Clinical Clinical Trials Complex compliance behavior Complication counterscreen Coupled design dorsal horn Dose-Limiting drug discovery Drug Kinetics Drug Targeting duloxetine Dysesthesias effective therapy Effectiveness Esthesia Feeling Fiber G-Protein-Coupled Receptors Human improved In Vitro in vivo Indigenous inhibitor/antagonist Ion Channel Laboratories Lavandula Lead Malignant Neoplasms Mediating Mediator of activation protein Medical Medicinal Plants meetings Modeling Muscle relaxants Natural Products Neuraxis neuronal excitability Neurons Neuropathy neurotoxic neurotoxicity neurotransmission non-opioid analgesic Norepinephrine novel novel therapeutics Numbness Opiate Addiction Opioid opioid misuse Opioid Receptor opioid sparing opioid use Oral Paclitaxel Pain Pain management pain model pain relief pain signal painful neuropathy Paresthesia Pathogenesis Pathway interactions Peripheral Peripheral Nerves Peripheral Nervous System Peripheral Nervous System Diseases Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Plants Platinum Compounds preclinical study Prevalence Property Protein Isoforms Proteins Quality of life Rattus Regimen Regulation reuptake Role Safety screening Sensory sensory stimulus Serotonin Shock side effect Site small molecule somatosensory Southwestern United States Specificity Spinal Spinal Cord Spinal Ganglia Structure success Survival Rate synaptic function T-Type Calcium Channels taxane Testing Tissues Translating Treatment Protocols Universities venlafaxine Vinca Alkaloids voltage Work |
| 论"气脱者,目不明" 期刊论文
发表期刊: 中医杂志. 出版年: 2017, 卷号: 58, 期号: 8, 页码: 640-643
作者: 盛倩; 庄曾渊
收藏 | 浏览/下载：9/0 | 提交时间：2019/11/29
Qi desertion poor eyesight pathogenesis method of treatment |
| Host-specificity of myxoma virus: Pathogenesis of South American and North American strains of myxoma virus in two North American lagomorph species 期刊论文
发表期刊: VETERINARY MICROBIOLOGY. 出版年: 2010, 卷号: 141, 期号: 3-4, 页码: 289-300
作者: Silvers, L.; Barnard, D.; Knowlton, F.; Inglis, B.; Labudovic, A.; Holland, M. K.; Janssens, P. A.; van Leeuwen, B. H.; Kerr, P. J.
收藏 | 浏览/下载：19/0 | 提交时间：2019/11/29
Myxomatosis Myxoma virus Sylvilagus Pathogenesis Rabbit |
| 小麦蓝矮植原体毒性因子基因的分离鉴定及其致病性的研究 项目
项目编号: 30871625. 资助机构: CN-NSFC（国家自然科学基金）. 起止日期: 2009-2011
负责人: 吴云锋
收藏 | 浏览/下载：11/0 | 提交时间：2021/01/13
wheat blue dwarf phytoplasma pathogenesis factors pathogenesis functional identification |
| Roles of Bacillus endospores in the environment 期刊论文
发表期刊: CELLULAR AND MOLECULAR LIFE SCIENCES. 出版年: 2002, 卷号: 59, 期号: 3, 页码: 410-416
作者: Nicholson, WL
收藏 | 浏览/下载：12/0 | 提交时间：2019/11/28
Bacillus spp. ecology endospore environment pathogenesis symbiosis |
