| 英文简介 | PROJECT NARRATIVE We will compare the DNA (whole genome genotype and exome sequencing) of 147 well-phenotyped people who developed disseminated coccidioidomycosis (DCM, aka, disseminated Valley Fever) with that of 388 people who had self-limited pulmonary coccidioidomycosis (PUL) in order to identify genetic patterns and differences associated with risk. In analyzing genotype data, we will look for associations between DCM and human leukocyte antigen (HLA) haplotypes, known immune response variants sets (reQTLs), and biological process pathways. In analyzing exome sequence data, we determine whether DCM patients carry more, or a different distribution of rare, damaging variation in candidate and unbiased biological process pathways. |
