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| Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis 项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2021
负责人: HUNG, CHIUNG YU
  收藏 | 浏览/下载：30/0 | 提交时间：2021/08/12
acute infection Adverse effects Affect Americas Amphotericin B Animals Antifungal Agents Antimicrobial Resistance Area base Biological Assay Caliber Caspofungin Cell Membrane Permeability Cell Wall Cells chemotherapy Clinical Coccidioides Coccidioides immitis Coccidioides posadasii Coccidioidomycosis Communities Containment Contracts cost Cryptococcus Cryptococcus neoformans Cytochrome P450 Cytology cytotoxicity Data Databases desert fever Development Diagnosis Disease Dose drug development Drug usage drug use screening Flow Cytometry Fluconazole follow-up fungus Goals Government Growth Hand Human Hyphae Image In Vitro in vivo Incubated indexing Infection Inhalation insight Lead Legal patent Libraries Life Cycle Stages Lower respiratory tract structure Lung Lung diseases Medical Medical Research Meningitis Methods Mexico Microscope Morphology Motivation Mycoses Neuraxis novel novel strategies novel therapeutics off-patent pathogen pathogenic fungus Patients Pharmaceutical Preparations Pharmacology Phase IV Clinical Trials Phenotype Pneumonia preclinical development prevent Process Property Reporting Reproduction spores Research Personnel resistant strain Resolution screening small molecule libraries Soil South America Southwestern United States Speed success Symptoms synergism Techniques Testing The science of Mycology Time Toxic effect United States United States National Institutes of Health Vaccines |
| Understanding the natural Coccidioides bioaerosol in time and space and its relationship to disease 项目
项目编号: 1R21AI149660-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: ENGELTHALER, DAVID M
收藏 | 浏览/下载：28/0 | 提交时间：2021/08/12
Address Aerosols Affect Air air filter air sampling Animals Area beta diversity Biological Assay Canis familiaris Climate climate change Coccidioides Coccidioidomycosis Collection Communities Community Health Data desert fever Detection Development Disease disease natural history disorder risk DNA Dust Ecology Environment Environmental Monitoring Environmental Risk Factor Environmental Wind epidemiologic data Epidemiology Event exposed human population Exposure to Fungal DNA Fungal Spores fungus Genomics Health Health Care Costs healthcare community Human Human Activities Humidity Incidence Infection Inhalation Knowledge knowledge base Locales Location Meteorology metropolitan microbiome analysis Modeling Monitor Morbidity - disease rate Movement Multivariate Analysis mycobiome Nature novel strategies Outcome Particulate Matter pathogen pathogenic fungus Pattern Population Precipitation predictive modeling Prevalence process optimization prospective Public Health Recreation Research Research Personnel Risk Risk Factors risk mitigation Schools severe weather Site Soil Source Southwestern United States Spatial Distribution suburb System Temperature The science of Mycology Time Veterinarians Weather whole genome Work Workplace |
| Project 2 - Macrophage regulation of fibrosis and scarring during tissue regeneration 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: GODWIN, JAMES W
收藏 | 浏览/下载：32/0 | 提交时间：2021/08/12
Address Adult Aging Animal Model Antigens Biological Assay Biological Models Brain Carbohydrates Cell Proliferation cell type Cells cellular targeting Cessation of life Cicatrix Comparative Biology Complex crosslink Development Disease Enzymes Epithelial Epithelial Cells Epithelium Exposure to Extracellular Matrix Fibroblasts Fibrosis Gene Expression Gene Expression Profile Genes Goals healing Healthcare Heart Human human tissue Immune Infection Infiltration Injury Innate Immune System innovation insight Label Laboratories Leukocytes limb amputation limb regeneration Limb structure Liver Lung macrophage Mammals Measures Mediating Mesenchymal Methods Modernization Molecular Myofibroblast Natural regeneration novel Operative Surgical Procedures Organ overexpression Patients Pattern Pharmacology Phenotype Play prevent Process progenitor programs Protein-Lysine 6-Oxidase Proteins PTPRC gene Recovery of Function regenerative regenerative therapy Regulation repaired RNA Interference Role Salamander Signal Pathway Signal Transduction Site Source Spinal Cord Stem cells Surface Testing therapy development Time time use tissue regeneration tissue repair Tissues tool transcriptome sequencing transdifferentiation Traumatic injury wound Wound Healing |
| Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人: KHANNA, RAJESH
收藏 | 浏览/下载：39/0 | 提交时间：2021/08/12
Absence of pain sensation addiction Affect Afferent Neurons American Amitriptyline Analgesics analog Antidepressive Agents Arizona Axon Baclofen base Betulinic Acid Biological Assay biophysical properties Calcium Calcium Channel Blockers Calcium Channel Inhibition cancer pain Cancer Patient cancer survival cancer therapy Cell-Mediated Cytolysis Cells central sensitization chemotherapeutic agent chemotherapy Chemotherapy-induced peripheral neuropathy Chemotherapy-Oncologic Procedure Chronic chronic pain chronic pain relief chronic painful condition Clinical Clinical Trials Complex compliance behavior Complication counterscreen Coupled design dorsal horn Dose-Limiting drug discovery Drug Kinetics Drug Targeting duloxetine Dysesthesias effective therapy Effectiveness Esthesia Feeling Fiber G-Protein-Coupled Receptors Human improved In Vitro in vivo Indigenous inhibitor/antagonist Ion Channel Laboratories Lavandula Lead Malignant Neoplasms Mediating Mediator of activation protein Medical Medicinal Plants meetings Modeling Muscle relaxants Natural Products Neuraxis neuronal excitability Neurons Neuropathy neurotoxic neurotoxicity neurotransmission non-opioid analgesic Norepinephrine novel novel therapeutics Numbness Opiate Addiction Opioid opioid misuse Opioid Receptor opioid sparing opioid use Oral Paclitaxel Pain Pain management pain model pain relief pain signal painful neuropathy Paresthesia Pathogenesis Pathway interactions Peripheral Peripheral Nerves Peripheral Nervous System Peripheral Nervous System Diseases Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Plants Platinum Compounds preclinical study Prevalence Property Protein Isoforms Proteins Quality of life Rattus Regimen Regulation reuptake Role Safety screening Sensory sensory stimulus Serotonin Shock side effect Site small molecule somatosensory Southwestern United States Specificity Spinal Spinal Cord Spinal Ganglia Structure success Survival Rate synaptic function T-Type Calcium Channels taxane Testing Tissues Translating Treatment Protocols Universities venlafaxine Vinca Alkaloids voltage Work |
| The interactions between gut microbiota and entomopathogenic fungi: a potential approach for biological control of Blattella germanica (L.) 期刊论文
发表期刊: PEST MANAGEMENT SCIENCE. 出版年: 2018, 卷号: 74, 期号: 2, 页码: 438-447
作者: Zhang, Fan; Sun, Xiao X.; Zhang, Xian C.; Zhang, Shuo; Lu, Jie; Xia, Yong M.; Huang, Yan H.; Wang, Xue J.
收藏 | 浏览/下载：13/0 | 提交时间：2019/11/29
Blattella germanica anti-entomopathogenic fungi assay interactions gut microbiota biological control |
| Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust 项目
项目编号: 5P42ES004940-29. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-
负责人: ZHANG, DONNA D
收藏 | 浏览/下载：26/0 | 提交时间：2021/08/12
Adverse effects Affect airway epithelium Alveolar Arsenic Autophagocytosis base Binding Biological Assay Biological Markers Bronchiectasis Butter Carcinogens Cells Chemopreventive Agent Chronic Chronic Bronchitis Chronic Obstructive Airway Disease CRISPR/Cas technology Cytosol Data defense response Degradation Pathway Desert Climate Development Diet Dietary Supplementation Disease disease registry Dose Dust Epithelial Epithelial Cells epithelial to mesenchymal transition Epithelium Erythroid exposure route Exposure to Fibrosis Functional disorder Gene Expression Gene Targeting Generations Goals Health high risk In Vitro in vivo Infiltration Inflammation Inflammatory Ingestion Inhalation Injury Intervention Iron Lung Lung diseases Lung Inflammation lung injury Maintenance Malignant Neoplasms Measures Mediating Metal exposure Metals Mining mitochondrial dysfunction Molecular Mus mutant Non-Malignant Nuclear Occupational Health Organ Organelles Outcome Oxidative Stress particle Particulate Pathway interactions Poison Population Intervention Populations at Risk Preventive Preventive treatment prophylactic protein aggregate Proteins Public Health Pulmonary Emphysema remediation Reporting Research Respiratory physiology response Risk Role Severities Side Site Soil Structure Sulforaphane superfund site Supplementation Tail Testing Therapeutic Tight Junctions Tissues Toxic effect transcription factor transcriptomics wasting |
| Understanding germ cell pluripotency through an inducible P-granule degradation system 项目
项目编号: 5F32GM128248-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-2020
负责人: MARNIK, ELISABETH ADKINS
收藏 | 浏览/下载：19/0 | 提交时间：2021/08/12
Adult Animals Auxins base Biological Assay Caenorhabditis elegans Cell Nucleus Cell Proliferation cell type Clustered Regularly Interspaced Short Palindromic Repeats Complex CRISPR/Cas technology Cytoplasm Cytoplasmic Granules Data Development Engineering Exposure to Fertility Generations Genes Germ Germ Cells Goals Human Imagery in vivo Inherited innovation insight Long-Term Effects Malignant Neoplasms Messenger RNA Morphology mRNA Expression mRNA sequencing Muscle Neurites neuronal cell body Neurons Oocytes Organism pluripotency Postdoctoral Fellow premature prevent Process protein degradation Proteins rapid technique regenerative Regulation Reporter Research Research Personnel Ribonucleoproteins RNA Interference safety net sperm cell Stem cells Sterility System Techniques Testing Therapeutic Time Transcript Translations Work young adult |
| Feasibility of EPS-producing bacterial inoculation to speed up the sand aggregation in the Gurbantunggut Desert, Northwestern China 期刊论文
发表期刊: JOURNAL OF BASIC MICROBIOLOGY. 出版年: 2014, 卷号: 54, 期号: 12, 页码: 1378-1386
作者: Wu, Nan; Pan, Hui-Xia; Qiu, Dong; Zhang, Yuan-Ming
收藏 | 浏览/下载：15/0 | 提交时间：2019/11/29
Extracellular polymeric substances Paenibacillus mucilaginosus Acetylene reduction assay 16S rRNA gene sequence Biological soil crusts |
| Evaluation of various diagnostic techniques for Trypanosoma evansi infections in naturally infected camels 期刊论文
发表期刊: VETERINARY PARASITOLOGY. 出版年: 1997, 卷号: 69, 期号: 1-2, 页码: 49-54
作者: Pathak, KML; Singh, Y; Meirvenne, NV; Kapoor, M
收藏 | 浏览/下载：11/0 | 提交时间：2019/11/28
dromedary camel Trypanosoma evansi Trypanosomosis diagnosis biological test mercuric chloride test card agglutination test double antibody sandwich enzyme linked immunosorbent assay |
