中文版 | English
Arid
项目编号5P42ES004940-29
Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust
ZHANG, DONNA D
主持机构UNIVERSITY OF ARIZONA
开始日期2018
项目类别RESEARCH CENTERS
资助机构US-NIH（美国国立卫生研究院）
语种英语
国家美国
英文简介PROJECT NARRATIVE (Project 5: Zhang, Boitano, Lantz) Arsenic is a contaminant of soils that can be transported in dust particles and inhaled, causing respiratory and lung diseases. This project aims to investigate the detailed mechanism by which arsenic lung inflammation and malfunction occur. In turn, this will allow us to develop disease-preventive treatments for the populations at risk of arsenic dust inhalation.
英文关键词Adverse effects Affect airway epithelium Alveolar Arsenic Autophagocytosis base Binding Biological Assay Biological Markers Bronchiectasis Butter Carcinogens Cells Chemopreventive Agent Chronic Chronic Bronchitis Chronic Obstructive Airway Disease CRISPR/Cas technology Cytosol Data defense response Degradation Pathway Desert Climate Development Diet Dietary Supplementation Disease disease registry Dose Dust Epithelial Epithelial Cells epithelial to mesenchymal transition Epithelium Erythroid exposure route Exposure to Fibrosis Functional disorder Gene Expression Gene Targeting Generations Goals Health high risk In Vitro in vivo Infiltration Inflammation Inflammatory Ingestion Inhalation Injury Intervention Iron Lung Lung diseases Lung Inflammation lung injury Maintenance Malignant Neoplasms Measures Mediating Metal exposure Metals Mining mitochondrial dysfunction Molecular Mus mutant Non-Malignant Nuclear Occupational Health Organ Organelles Outcome Oxidative Stress particle Particulate Pathway interactions Poison Population Intervention Populations at Risk Preventive Preventive treatment prophylactic protein aggregate Proteins Public Health Pulmonary Emphysema remediation Reporting Research Respiratory physiology response Risk Role Severities Side Site Soil Structure Sulforaphane superfund site Supplementation Tail Testing Therapeutic Tight Junctions Tissues Toxic effect transcription factor transcriptomics wasting
URL4940
资源类型项目
条目标识符http://119.78.100.177/qdio/handle/2XILL650/356148
推荐引用方式
GB/T 7714		 ZHANG, DONNA D.Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust.2018.
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