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Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective 期刊论文
发表期刊: LIFE-BASEL. 出版年: 2022, 卷号: 12, 期号: 7
作者:  Khan, Farheen Badrealam;  Ansari, Mohammad Azam;  Uddin, Shahab;  Palakott, Abdul Rasheed;  Anwar, Irfa;  Almatroudi, Ahmad;  Alomary, Mohammad N.;  Alrumaihi, Faris;  Alkhayl, Faris F. Aba;  Alghamdi, Saad;  Muhammad, Khalid;  Huang, Chih-Yang;  Daddam, Jayasimha Rayalu;  Khan, Haroon;  Maqsood, Sajid;  Ayoub, Mohammed Akli
收藏  |  浏览/下载：21/0  |  提交时间：2024/09/20
bioactive peptides  camel milk  cancer  diabetes  molecular signaling  exosomes  human diseases  therapeutics  
Systems-level genetic patterns underlying disseminated coccidioidomycosis in humans 项目
项目编号: 1R21AI152394-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人:  LUSSIER, YVES A.
收藏  |  浏览/下载：31/0  |  提交时间：2021/08/12
Acute  Address  adverse outcome  African American  Alleles  Automobile Driving  Biochemical  Biological  Biological Process  Biology  bone  Brain  Candidate Disease Gene  Caring  Case Study  Categories  causal variant  Chronic  Clinical  clinical care  Coccidioides  Coccidioidomycosis  Code  cohort  Communicable Diseases  Complex  Data  Databases  desert fever  design  Disease  Disease susceptibility  DNA  Emerging Communicable Diseases  Equilibrium  Exogenous Factors  exome  exome sequencing  experience  Filipino  flu  Foundations  fungus  Gene Expression  Gene Mutation  Genes  Genetic  genetic architecture  Genetic Heterogeneity  Genetic Predisposition to Disease  genetic risk factor  Genetic Variation  genome-wide  genome-wide analysis  Genotype  genotyped patients  Guidelines  Haplotypes  Heterogeneity  high risk  HLA Antigens  Human  Human Genetics  human leukocyte antigen testing  IFNGR1 gene  IL12RB1 gene  Immune  Immune response  Immune system  Immunocompetent  Immunogenetics  Immunological Models  Immunosuppression  Infection  Inhalation  insight  Knowledge  Life  Lung  Medical  Modeling  Molecular  Mutation  Mycoses  National Institute of Allergy and Infectious Disease  novel  Organ  Participant  pathogen  pathogen exposure  Pathogenesis  pathogenic fungus  Pathology  Pathway Analysis  Pathway interactions  Patients  Pattern  Phenotype  Play  Pneumonia  Positioning Attribute  Predisposition  Proteins  Quantitative Trait Loci  rare variant  Recommendation  recruit  Resistance  Resources  response  Risk  risk variant  Role  Sample Size  Sampling Studies  Signal Transduction  Skin  Soil  STAT1 gene  STAT3 gene  Stimulus  Symptoms  System  Systems Analysis  Testing  Therapeutic  Time  Variant  whole genome  
Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis 项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2021
负责人:  HUNG, CHIUNG YU
收藏  |  浏览/下载：30/0  |  提交时间：2021/08/12
acute infection  Adverse effects  Affect  Americas  Amphotericin B  Animals  Antifungal Agents  Antimicrobial Resistance  Area  base  Biological Assay  Caliber  Caspofungin  Cell Membrane Permeability  Cell Wall  Cells  chemotherapy  Clinical  Coccidioides  Coccidioides immitis  Coccidioides posadasii  Coccidioidomycosis  Communities  Containment  Contracts  cost  Cryptococcus  Cryptococcus neoformans  Cytochrome P450  Cytology  cytotoxicity  Data  Databases  desert fever  Development  Diagnosis  Disease  Dose  drug development  Drug usage  drug use screening  Flow Cytometry  Fluconazole  follow-up  fungus  Goals  Government  Growth  Hand  Human  Hyphae  Image  In Vitro  in vivo  Incubated  indexing  Infection  Inhalation  insight  Lead  Legal patent  Libraries  Life Cycle Stages  Lower respiratory tract structure  Lung  Lung diseases  Medical  Medical Research  Meningitis  Methods  Mexico  Microscope  Morphology  Motivation  Mycoses  Neuraxis  novel  novel strategies  novel therapeutics  off-patent  pathogen  pathogenic fungus  Patients  Pharmaceutical Preparations  Pharmacology  Phase IV Clinical Trials  Phenotype  Pneumonia  preclinical development  prevent  Process  Property  Reporting  Reproduction spores  Research Personnel  resistant strain  Resolution  screening  small molecule libraries  Soil  South America  Southwestern United States  Speed  success  Symptoms  synergism  Techniques  Testing  The science of Mycology  Time  Toxic effect  United States  United States National Institutes of Health  Vaccines  
Project 3 - Defining the role of ribosome protein composition in regulating the selective translation of pro-longevity genes 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人:  ROLLINS, JAROD ALTON
收藏  |  浏览/下载：22/0  |  提交时间：2021/08/12
Address  Adult  Affect  Age  age related  Aging  aging gene  Animal Model  Animals  Biology of Aging  Caenorhabditis elegans  Caloric Restriction  Cardiovascular Diseases  Chronic  Comparative Biology  Cost of Illness  CRISPR/Cas technology  Data  Databases  Development  differential expression  Disease  Drosophila genus  Exposure to  Gene Expression  Genes  Genetic  genetic manipulation  Genetic Models  Genetic Transcription  Genetic Translation  Genome engineering  Goals  Health  Health Expenditures  healthy aging  High-Throughput RNA Sequencing  Human  innovation  insight  Invertebrates  knock-down  Life  Longevity  longevity gene  Malignant Neoplasms  Mass Spectrum Analysis  Mediating  Messenger RNA  middle age  Molecular  Molecular Machines  mRNA sequencing  Mus  Natural regeneration  Nerve Degeneration  novel  overexpression  Pathway interactions  Pharmacologic Substance  Polyribosomes  polysome profiling  prevent  Process  Proteins  Proteomics  Ribosomal Proteins  Ribosomes  Risk Factors  RNA Interference  Role  stressor  Testing  therapy development  Time  tissue repair  Transcript  transcriptomics  Translating  Translations  Vertebrates  Yeasts  
Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人:  KHANNA, RAJESH
收藏  |  浏览/下载：39/0  |  提交时间：2021/08/12
Absence of pain sensation  addiction  Affect  Afferent Neurons  American  Amitriptyline  Analgesics  analog  Antidepressive Agents  Arizona  Axon  Baclofen  base  Betulinic Acid  Biological Assay  biophysical properties  Calcium  Calcium Channel Blockers  Calcium Channel Inhibition  cancer pain  Cancer Patient  cancer survival  cancer therapy  Cell-Mediated Cytolysis  Cells  central sensitization  chemotherapeutic agent  chemotherapy  Chemotherapy-induced peripheral neuropathy  Chemotherapy-Oncologic Procedure  Chronic  chronic pain  chronic pain relief  chronic painful condition  Clinical  Clinical Trials  Complex  compliance behavior  Complication  counterscreen  Coupled  design  dorsal horn  Dose-Limiting  drug discovery  Drug Kinetics  Drug Targeting  duloxetine  Dysesthesias  effective therapy  Effectiveness  Esthesia  Feeling  Fiber  G-Protein-Coupled Receptors  Human  improved  In Vitro  in vivo  Indigenous  inhibitor/antagonist  Ion Channel  Laboratories  Lavandula  Lead  Malignant Neoplasms  Mediating  Mediator of activation protein  Medical  Medicinal Plants  meetings  Modeling  Muscle relaxants  Natural Products  Neuraxis  neuronal excitability  Neurons  Neuropathy  neurotoxic  neurotoxicity  neurotransmission  non-opioid analgesic  Norepinephrine  novel  novel therapeutics  Numbness  Opiate Addiction  Opioid  opioid misuse  Opioid Receptor  opioid sparing  opioid use  Oral  Paclitaxel  Pain  Pain management  pain model  pain relief  pain signal  painful neuropathy  Paresthesia  Pathogenesis  Pathway interactions  Peripheral  Peripheral Nerves  Peripheral Nervous System  Peripheral Nervous System Diseases  Pharmaceutical Preparations  Pharmacology  Pharmacotherapy  Phase  Plants  Platinum Compounds  preclinical study  Prevalence  Property  Protein Isoforms  Proteins  Quality of life  Rattus  Regimen  Regulation  reuptake  Role  Safety  screening  Sensory  sensory stimulus  Serotonin  Shock  side effect  Site  small molecule  somatosensory  Southwestern United States  Specificity  Spinal  Spinal Cord  Spinal Ganglia  Structure  success  Survival Rate  synaptic function  T-Type Calcium Channels  taxane  Testing  Tissues  Translating  Treatment Protocols  Universities  venlafaxine  Vinca Alkaloids  voltage  Work  
Citizen science for development: Potential role of mobile phones in information sharing on ticks and tick-borne diseases in Laikipia, Kenya 期刊论文
发表期刊: NJAS-WAGENINGEN JOURNAL OF LIFE SCIENCES. 出版年: 2018, 卷号: 86-87, 页码: 123-135
作者:  Chepkwony, Richard;  van Bommel, Severine;  van Langevelde, Frank
收藏  |  浏览/下载：24/0  |  提交时间：2019/11/29
EVOCA  Insecurity  Human-wildlife conflicts  Diseases  Empowerment  Mobile phones  
Ethnopharmacological and Phytopharmaceutical Evaluation of Prosopis cineraria: An Overview and Future Prospects 期刊论文
发表期刊: CURRENT DRUG METABOLISM. 出版年: 2018, 卷号: 19, 期号: 3, 页码: 192-213
作者:  Chaudhary, Kamal K.;  Kumar, Gautam;  Varshney, Anusheel;  Meghvansi, Mukesh K.;  Ali, Syed Farook;  Karthik, Kumaragurubaran;  Dhama, Kuldeep;  Siddiqui, Sazada;  Kaul, Ramesh K.
收藏  |  浏览/下载：24/0  |  提交时间：2019/11/29
Prosopis cineraria  thar dessert  nutrition  phytochemistry  ethanopharmacology  human diseases  
The Roles of Complement C4A and C4B Genetic Diversity and HLA DRB1 Variants on Disease Associations with Juvenile Dermatomyositis and Systemic Lupus Erythematosus 学位论文
学位授予机构: The Ohio State University / OhioLINK. 出版年: 2016
作者:  Lintner;Katherine E
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/29
Molecular Biology  Immunology  Genetics  Autoimmune diseases  Systemic lupus erythematosus  Juvenile dermatomyositis  Complement system  Complement C4  Human leukocyte antigen region  
Birds, bats and arthropods in tropical agroforestry landscapes: Functional diversity, multitrophic interactions and crop yield 学位论文
出版年: 2013
作者:  Maas;Bea
收藏  |  浏览/下载：28/0  |  提交时间：2019/11/29
630  Birds  Bats  Arthropods  Multitrophic interactions  Agroforestry  Tropical landscape  Forest margin landscape  Functional diversity  Crop yield  Exclosure experiments  Experimental exclusion  Arthropod suppression  Avian predation  Ecosystem services  Mist netting  Point counts  Artificial plasticine caterpillar  Dummy experiment  Biological control  Monitoring  Mapping  Lemon-bellied White-eye  Grosbeak Starling  Zosterops chloris  Scissiostrum dubium  Theobroma cacao  Cacao agroforestry  Cacao diseases  Cacao harvest  Cacao pests  Flying vertebrates  Aerial insectivores  Volant vertebrates  Logging  Breeding colony  Flower herbivory  Mesopredator release  Predatory insects  Ants  Spiders  Aphids  Lepidoptera  Coleoptera  Lepidopteran larvae  Sustainable agriculture  Sustainable agroforestry  Management implications  Management recommendations  Applied managament  Extensive land use management  Landscape management  Conservation  Biodiversity-friendly  Dbh  Distance to forest  Forest proximity  Habitat conversion  Herbivory  Indonesia  Insectivorous bats  Insectivorous birds  Invertebrates  Central Sulawesi  Napu valley  Leaf gleaning  Leaf herbivory  Pests insects  Phytophagous insects  Plant productivity  Remnant forest trees  Shade tree managament  South-east Asia  Paleotropics  Tropical landscape  Tree height  Landscape gradient  Local shade management  Cacao Pod Borer  Cherelle Wilt  Fruit abortion  Helopeltis sulawesi  Deforestation  Habitat fragmentation  Land use intensification  Forest margin species  Critical decline  Predation experiment  Species-specific functions  Southeast Asia  Biodiversity conservation  Mesopredators  Food security  Human welfare  Human well-being  Poverty alleviation  Poverty reduction  Smallholder cacao  Smallholder plantation  Cacao farmers  Sustainable cacao management  Landscape perspective  Landscape scale  Large scale field experiment  Long term field experiment  Human wellbeing  Economic importance  Economic value  Valuation ecosystem services  Landscape matrix  Yield quality  Yield quantity  Fruit productivity  Species identity  Species diversity  Species richness  Ecosystem functioning  Pesticide use  Chemical compounds  Complex food web  Tritrophic interactions  Wildlife-friendly  Rural livelihoods  Endangered bird species  Endangered bat species  Endemic  Endemic birds  Endemic bats  Beneficial impact  IUCN  Lore Lindu National Park  Bioindicator  Indicator species  Forest margin  Agricultural habitat  Agroforestry systems  Population density  Predation activity  Species activity  Cacao flower  Cacao pod  Orthoptera  Linear mixed effect models  Tukey Post Hoc Test  AICc model selection  Generalized least squares  Restricted maximum likelihood  Model simplification  Species richness estimator  Species accumulation  Linear mixed-effects models  Likelihood Ratio Test  Maximum Likelihood  Nocturnal insects  Diurnal arthropods  Nocturnal arthropods  Diurnal insects  Landscape context  Land- und Forstwirtschaft (PPN621302791)  
Environmental pollution and child health in the Aral Sea region in Kazakhstan 期刊论文
发表期刊: SCIENCE OF THE TOTAL ENVIRONMENT. 出版年: 1997, 卷号: 206, 期号: 2-3, 页码: 187-193
作者:  Jensen, S;  Mazhitova, Z;  Zetterstrom, R
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/28
environment pollution  human health  DDT compounds  HCH compounds  PCB compounds  heavy metals  concentration in blood  ecological diseases