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Desert Environments Facilitate Unique Evolution of Biosynthetic Potential in Streptomyces 期刊论文
发表期刊: MOLECULES. 出版年: 2021, 卷号: 26, 期号: 3
作者:  Sivakala, Kunjukrishnan Kamalakshi;  Gutierrez-Garcia, Karina;  Jose, Polpass Arul;  Thinesh, Thangadurai;  Anandham, Rangasamy;  Barona-Gomez, Francisco;  Sivakumar, Natesan
收藏  |  浏览/下载:4/0  |  提交时间:2021/03/08
actinobacteria  genome mining  metabolomics  secondary metabolites  natural products  arid environment  
Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns 期刊论文
发表期刊: MICROBIOLOGY-SGM. 出版年: 2019, 卷号: 165, 期号: 12, 页码: 1252-1264
作者:  Bull, Alan T.;  Goodfellow, Michael
收藏  |  浏览/下载:9/0  |  提交时间:2021/11/30
extremobiosphere  actinobacteria  microbial dark matter  bioprospecting  bioactive natural products  deep seas  hyper-arid desert  genome mining  
Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis 项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2018-2020
负责人:  BAKER, BILL J;  CHAIN, PATRICK S. G.;  MURRAY, ALISON ELIZABETH (contact)
收藏  |  浏览/下载:3/0  |  提交时间:2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A  Anabolism  Antarctic  Architecture  ascidian  Atmosphere  Bacteria  Bacterial Genome  base  Base Sequence  Bioinformatics  cancer therapy  candidate validation  cell growth  Cell Line  cell type  Cells  chemotherapeutic agent  chemotherapy  Clinical  Code  contig  Cytostatics  cytotoxicity  Data  Development  Diagnosis  Disease  drug development  Drug Targeting  fighting  Gene Cluster  Genes  genetic manipulation  Genome  Genome Mappings  genome sequencing  Genomics  Goals  Harvest  High-Risk Cancer  Human Cell Line  Hybrids  Immunotherapy  In Vitro  indexing  insight  interest  Ligase  Macrolides  Marines  markov model  Melanins  melanocyte  melanoma  Melanoma Cell  metagenome  metagenomic sequencing  Metastatic Melanoma  microbial  microbiome  microorganism  Mining  Modeling  Molecular  Mutagenesis  Natural Products  New Agents  next generation  novel  Organism  Outcomes Research  Pathway interactions  peptide synthase  Pharmaceutical Preparations  Pharmacology  polyketide synthase  Preparation  Procedures  Production  Proton Pump  reference genome  Research  research and development  Resistance  Resistance development  Ribosomal RNA  Risk  scale up  screening  Signal Transduction Pathway  Skin  Skin Cancer  Source  Specificity  Specimen  stratospheric ozone  Structure  Survival Rate  symbiont  System  targeted agent  Therapeutic  tool  Toxic effect  Treatment Efficacy  tumor  Ultraviolet Rays  United States  vacuolar H+-ATPase  whole genome  
The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2 期刊论文
发表期刊: BMC GENOMICS. 出版年: 2015, 卷号: 16
作者:  Gomez-Escribano, Juan Pablo;  Castro, Jean Franco;  Razmilic, Valeria;  Chandra, Govind;  Andrews, Barbara;  Asenjo, Juan A.;  Bibb, Mervyn J.
收藏  |  浏览/下载:3/0  |  提交时间:2019/11/29
Second/Third next generation sequencing  Illumina MiSeq  Pacific Biosciences PacBio SMRT  Chaxamycin  Chaxalactin  Lasso peptide  Genome mining