干旱区生态环境知识资源中心(Arid): Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns

Arid

DOI	10.1099/mic.0.000822
	Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns
	Bull, Alan T.; Goodfellow, Michael
通讯作者	Bull, AT (corresponding author), Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England.
来源期刊	MICROBIOLOGY-SGM
ISSN	1350-0872
EISSN	1465-2080
出版年	2019
卷号	165 期号:12 页码:1252-1264
英文摘要	The rationale of our bioprospecting campaigns is that the extremobiosphere, particularly the deep sea and hyper-arid deserts. harbours undiscovered biodiversity that is likely to express novel chemistry and biocatalysts thereby providing opportunities for therapeutic drug and industrial process development. We have focused on actinobacteria because of their frequent role as keystone species in soil ecosystems and their unrivalled track record as a source of bioactive compounds. Population numbers and diversity of actinobacteria in the extremobiosphere are traditionally considered to be low, although they often comprise the dominant bacterial biota. Recent metagenomic evaluation of 'the uncultured microbial majority' has now revealed enormous taxonomic diversity among 'dark' and 'rare' actinobacteria in samples as diverse as sediments from the depths of the Mariana Trench and soils from the heights of the Central Andes. The application of innovative culture and screening options that emphasize rigorous dereplication at each stage of the analysis, and strain prioritization to identify 'gifted' organisms, have been deployed to detect and characterize bioactive hit compounds and sought-after catalysts from this hitherto untapped resource. The rewards include first-in-a-class chemical entities with novel modes of action, as well as a growing microbial seed bank that represents a potentially enormous source of biotechnological and therapeutic innovation.
英文关键词	extremobiosphere actinobacteria microbial dark matter bioprospecting bioactive natural products deep seas hyper-arid desert genome mining
类型	Review
语种	英语
开放获取类型	Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000522796500002
WOS关键词	HYPER-ARID SOILS ; ATACAMA DESERT ; SP NOV. ; DERMACOCCUS-ABYSSI ; HIGH-ALTITUDE ; SEA-FLOOR ; A-D ; STRAIN ; ACTINOBACTERIA ; DIVERSITY
WOS类目	Microbiology
WOS研究方向	Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/369652
作者单位	[Bull, Alan T.] Univ Kent, Sch Biosci, Canterbury CT2 7NJ, Kent, England; [Goodfellow, Michael] Newcastle Univ, Sch Nat & Environm Sci, Ridley Bldg 2, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
推荐引用方式 GB/T 7714	Bull, Alan T.,Goodfellow, Michael. Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns[J],2019,165(12):1252-1264.
APA	Bull, Alan T.,&Goodfellow, Michael.(2019).Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns.MICROBIOLOGY-SGM,165(12),1252-1264.
MLA	Bull, Alan T.,et al."Dark, rare and inspirational microbial matter in the extremobiosphere: 16 000 m of bioprospecting campaigns".MICROBIOLOGY-SGM 165.12(2019):1252-1264.