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| Project 2 - Macrophage regulation of fibrosis and scarring during tissue regeneration 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: GODWIN, JAMES W
  收藏 | 浏览/下载：30/0 | 提交时间：2021/08/12
Address Adult Aging Animal Model Antigens Biological Assay Biological Models Brain Carbohydrates Cell Proliferation cell type Cells cellular targeting Cessation of life Cicatrix Comparative Biology Complex crosslink Development Disease Enzymes Epithelial Epithelial Cells Epithelium Exposure to Extracellular Matrix Fibroblasts Fibrosis Gene Expression Gene Expression Profile Genes Goals healing Healthcare Heart Human human tissue Immune Infection Infiltration Injury Innate Immune System innovation insight Label Laboratories Leukocytes limb amputation limb regeneration Limb structure Liver Lung macrophage Mammals Measures Mediating Mesenchymal Methods Modernization Molecular Myofibroblast Natural regeneration novel Operative Surgical Procedures Organ overexpression Patients Pattern Pharmacology Phenotype Play prevent Process progenitor programs Protein-Lysine 6-Oxidase Proteins PTPRC gene Recovery of Function regenerative regenerative therapy Regulation repaired RNA Interference Role Salamander Signal Pathway Signal Transduction Site Source Spinal Cord Stem cells Surface Testing therapy development Time time use tissue regeneration tissue repair Tissues tool transcriptome sequencing transdifferentiation Traumatic injury wound Wound Healing |
| Project 1 - Disruption of CpG island-mediated gene regulation and chromatin architecture in progeria and aging 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: BECK, SAMUEL
收藏 | 浏览/下载：27/0 | 提交时间：2021/08/12
Address Age of Onset age related Aging Architecture Atherosclerosis Biological Biology of Aging Biomedical Research Blindness Cardiac Myocytes Cell Differentiation process Cells Chromatin Chromosome Mapping Comparative Biology CpG Islands CRISPR/Cas technology Cytosine Data Set de novo mutation Defect Degenerative Disorder Dinucleoside Phosphates Disease DNA DNA Damage DNA Repair Economics Elements epigenetic regulation Euchromatin Fatty Liver Fluorescent in Situ Hybridization Frequencies Gene Expression Gene Expression Regulation Genes Genetic Genetic Transcription genome editing genome-wide Genomic Instability Goals Guanine Hair Hepatocyte Heterochromatin Impairment induced pluripotent stem cell innovation inorganic phosphate insight Lamin Type A Lamins Life Life Expectancy Link Mediating Meta-Analysis Modeling Molecular Morphology mRNA sequencing Musculoskeletal Mutation Natural regeneration Nuclear Nuclear Lamin Nuclear Lamina Pathology Patients Peripheral Physiological Predisposition prevent Process Progeria promoter Property Proteins Psyche structure Public Health Regulation Resources response restoration Skin Structural Protein Symptoms Testing therapy development tissue repair Tissues Undifferentiated |
| Project 3 - Defining the role of ribosome protein composition in regulating the selective translation of pro-longevity genes 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: ROLLINS, JAROD ALTON
收藏 | 浏览/下载：20/0 | 提交时间：2021/08/12
Address Adult Affect Age age related Aging aging gene Animal Model Animals Biology of Aging Caenorhabditis elegans Caloric Restriction Cardiovascular Diseases Chronic Comparative Biology Cost of Illness CRISPR/Cas technology Data Databases Development differential expression Disease Drosophila genus Exposure to Gene Expression Genes Genetic genetic manipulation Genetic Models Genetic Transcription Genetic Translation Genome engineering Goals Health Health Expenditures healthy aging High-Throughput RNA Sequencing Human innovation insight Invertebrates knock-down Life Longevity longevity gene Malignant Neoplasms Mass Spectrum Analysis Mediating Messenger RNA middle age Molecular Molecular Machines mRNA sequencing Mus Natural regeneration Nerve Degeneration novel overexpression Pathway interactions Pharmacologic Substance Polyribosomes polysome profiling prevent Process Proteins Proteomics Ribosomal Proteins Ribosomes Risk Factors RNA Interference Role stressor Testing therapy development Time tissue repair Transcript transcriptomics Translating Translations Vertebrates Yeasts |
| Deciphering the metagenome-encoded pathway and domain structure for Palmerolide biosynthesis 项目
项目编号: 5R21CA205932-02. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2018-2020
负责人: BAKER, BILL J; CHAIN, PATRICK S. G.; MURRAY, ALISON ELIZABETH (contact)
收藏 | 浏览/下载：23/0 | 提交时间：2021/08/12
3-hydroxy-3-methylglutaryl-coenzyme A Anabolism Antarctic Architecture ascidian Atmosphere Bacteria Bacterial Genome base Base Sequence Bioinformatics cancer therapy candidate validation cell growth Cell Line cell type Cells chemotherapeutic agent chemotherapy Clinical Code contig Cytostatics cytotoxicity Data Development Diagnosis Disease drug development Drug Targeting fighting Gene Cluster Genes genetic manipulation Genome Genome Mappings genome sequencing Genomics Goals Harvest High-Risk Cancer Human Cell Line Hybrids Immunotherapy In Vitro indexing insight interest Ligase Macrolides Marines markov model Melanins melanocyte melanoma Melanoma Cell metagenome metagenomic sequencing Metastatic Melanoma microbial microbiome microorganism Mining Modeling Molecular Mutagenesis Natural Products New Agents next generation novel Organism Outcomes Research Pathway interactions peptide synthase Pharmaceutical Preparations Pharmacology polyketide synthase Preparation Procedures Production Proton Pump reference genome Research research and development Resistance Resistance development Ribosomal RNA Risk scale up screening Signal Transduction Pathway Skin Skin Cancer Source Specificity Specimen stratospheric ozone Structure Survival Rate symbiont System targeted agent Therapeutic tool Toxic effect Treatment Efficacy tumor Ultraviolet Rays United States vacuolar H+-ATPase whole genome |
| Targeting Tumor Oct4 to Deplete Prostate Tumor and Metastasis Initiating Cells. 科技报告
报告编号: AD1049890. 出版年: 2017
作者: Nie, D.
收藏 | 浏览/下载：23/0 | 提交时间：2019/11/30
Prostate cancer Neoplasms Gene expression Genetics Amino acids Cell line Metastasis Epithelial cells Cell nucleus Stem cells Chromosomes Cell physiological processes Therapy Oct4 Cancer stem cells Tumor formation |
| Schwann Cell-Derived Desert Hedgehog Controls Limb Blood Vessel Network and Angiogenesis 期刊论文
发表期刊: CIRCULATION. 出版年: 2011, 卷号: 124, 期号: 21
作者: Chapouly, Candice; Yao, Qinyu; Robbesyn, Fanny; Allieres, Cecile; Jaspard-Vinassa, Beatrice; Reynaud, Annabel; Belloc, Isabelle; Traiffort, Elisabeth; Ruat, Martial; Duplaa, Cecile; Desgranges, Claude; Gadeau, Alain-Pierre; Renault, Marie-Ange
收藏 | 浏览/下载：13/0 | 提交时间：2019/11/29
Angiogenesis Transgenic models Gene therapy Vascular development |
| Brain Region and Cell Type Specific Approaches to Study Drug Abuse 学位论文
学位授予机构: The Ohio State University / OhioLINK. 出版年: 2011
作者: Naughton; Bartholomew J.; IV
收藏 | 浏览/下载：15/0 | 提交时间：2019/11/29
Biology Cellular Biology Molecular Biology Neurobiology Neurosciences Pharmacology Addiction Cocaine AAV Virus-mediated Bac transgenic mice Recombineering Nucleus accumbens ShRNA Transcriptional regulation Gene therapy |
| SONIC HEDGEHOG - A MORPHOGEN WITH THERAPEUTIC IMPORTANCE 期刊论文
发表期刊: POSTEPY BIOLOGII KOMORKI. 出版年: 2008, 卷号: 35, 期号: 4, 页码: 441-452
作者: Malecki, Maciej; Gladysz, Agnieszka; Moscicka, Katarzyna; Lipiec, Agnieszka
收藏 | 浏览/下载：29/0 | 提交时间：2019/11/28
sonic hedgehog (SHH) signal transduction angiogenic gene therapy |
| Rapid and reproducible radiosynthesis of [F-18] FHBG 期刊论文
发表期刊: NUCLEAR MEDICINE AND BIOLOGY. 出版年: 2004, 卷号: 31, 期号: 1, 页码: 133-138
作者: Ponde, DE; Dence, CS; Schuster, DP; Welch, MJ
收藏 | 浏览/下载：9/0 | 提交时间：2019/11/28
[F-18] FHBG PET thymidine kinase gene therapy solid phase purification Oasis (R) HLB microwave |
| Therapeutic angiogenesis: A case for targeted, regulated gene delivery 期刊论文
发表期刊: CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION. 出版年: 2000, 卷号: 10, 期号: 2, 页码: 113-125
作者: Webster, KA
收藏 | 浏览/下载：5/0 | 提交时间：2019/11/28
gene therapy limb ischemia myocardial ischemia hypoxia |
