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Splice modulatory therapy for valley fever 项目
项目编号: 1R21AI154106-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人:  BURKART, MICHAEL D.
收藏  |  浏览/下载：27/0  |  提交时间：2021/08/12
Acute Myelocytic Leukemia  Amphotericin B  analog  anti-cancer  Antifungal Agents  Arizona  Azoles  base  Biological  Biological Markers  Biology  California  cancer cell  Cells  Chemicals  Clinical  Coccidioides immitis  Coccidioides posadasii  Coccidioidomycosis  combat  Communities  desert fever  design  Development  Diagnosis  Disease  Drug Interactions  Dust  Evaluation  Event  Family  flu  Fluconazole  Funding  fungus  Future  Genes  Goals  high reward  high risk  Human  Incidence  Individual  Infection  Investigation  Laboratories  Lead  Left  Life  Messenger RNA  Modernization  Natural Products  new therapeutic target  next generation  novel  Oncogenic  Outcome  outcome forecast  Pathway interactions  Patients  Pattern  Pharmaceutical Chemistry  Pharmaceutical Preparations  Play  Pneumonia  Positioning Attribute  Precipitation  preclinical study  Preparation  programs  Reporting  RNA Splicing  scaffold  Seasons  Series  Side  side effect  small molecule  Spliceosomes  Structure  System  Systems Biology  Techniques  Testing  Therapeutic  therapeutic target  tool  transcriptome  transcriptomics  Translating  Translations  United States  Work  
Optimization of Betulinic Acid analogs for T-type calcium channel inhibition for non-addictive relief of chronic pain 项目
项目编号: 1R41DA050364-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-2020
负责人:  KHANNA, RAJESH
收藏  |  浏览/下载：36/0  |  提交时间：2021/08/12
Absence of pain sensation  addiction  Affect  Afferent Neurons  American  Amitriptyline  Analgesics  analog  Antidepressive Agents  Arizona  Axon  Baclofen  base  Betulinic Acid  Biological Assay  biophysical properties  Calcium  Calcium Channel Blockers  Calcium Channel Inhibition  cancer pain  Cancer Patient  cancer survival  cancer therapy  Cell-Mediated Cytolysis  Cells  central sensitization  chemotherapeutic agent  chemotherapy  Chemotherapy-induced peripheral neuropathy  Chemotherapy-Oncologic Procedure  Chronic  chronic pain  chronic pain relief  chronic painful condition  Clinical  Clinical Trials  Complex  compliance behavior  Complication  counterscreen  Coupled  design  dorsal horn  Dose-Limiting  drug discovery  Drug Kinetics  Drug Targeting  duloxetine  Dysesthesias  effective therapy  Effectiveness  Esthesia  Feeling  Fiber  G-Protein-Coupled Receptors  Human  improved  In Vitro  in vivo  Indigenous  inhibitor/antagonist  Ion Channel  Laboratories  Lavandula  Lead  Malignant Neoplasms  Mediating  Mediator of activation protein  Medical  Medicinal Plants  meetings  Modeling  Muscle relaxants  Natural Products  Neuraxis  neuronal excitability  Neurons  Neuropathy  neurotoxic  neurotoxicity  neurotransmission  non-opioid analgesic  Norepinephrine  novel  novel therapeutics  Numbness  Opiate Addiction  Opioid  opioid misuse  Opioid Receptor  opioid sparing  opioid use  Oral  Paclitaxel  Pain  Pain management  pain model  pain relief  pain signal  painful neuropathy  Paresthesia  Pathogenesis  Pathway interactions  Peripheral  Peripheral Nerves  Peripheral Nervous System  Peripheral Nervous System Diseases  Pharmaceutical Preparations  Pharmacology  Pharmacotherapy  Phase  Plants  Platinum Compounds  preclinical study  Prevalence  Property  Protein Isoforms  Proteins  Quality of life  Rattus  Regimen  Regulation  reuptake  Role  Safety  screening  Sensory  sensory stimulus  Serotonin  Shock  side effect  Site  small molecule  somatosensory  Southwestern United States  Specificity  Spinal  Spinal Cord  Spinal Ganglia  Structure  success  Survival Rate  synaptic function  T-Type Calcium Channels  taxane  Testing  Tissues  Translating  Treatment Protocols  Universities  venlafaxine  Vinca Alkaloids  voltage  Work  
Remote Science Support during MARS2013: Testing a Map-Based System of Data Processing and Utilization for Future Long-Duration Planetary Missions 期刊论文
发表期刊: ASTROBIOLOGY. 出版年: 2014, 卷号: 14, 期号: 5, 页码: 417-430
作者:  Losiak, Anna;  Golebiowska, Izabela;  Orgel, Csilla;  Moser, Linda;  MacArthur, Jane;  Boyd, Andrea;  Hettrich, Sebastian;  Jones, Natalie;  Groemer, Gernot
收藏  |  浏览/下载：28/0  |  提交时间：2019/11/29
Planetary surface operations  Planetary mapping  Remote science support  Analog testing  Long-duration planetary missions  Mars exploration  
Desert Research and Technology Studies (DRATS) 2010 science operations: Operational approaches and lessons learned for managing science during human planetary surface missions 期刊论文
发表期刊: ACTA ASTRONAUTICA. 出版年: 2013, 卷号: 90, 期号: 2, 页码: 224-241
作者:  Eppler, Dean;  Adams, Byron;  Archer, Doug;  Baiden, Greg;  Brown, Adrian;  Carey, William;  Cohen, Barbara;  Condit, Chris;  Evans, Cindy;  Fortezzo, Corey;  Garry, Brent;  Graff, Trevor;  Gruener, John;  Heldmann, Jennifer;  Hodges, Kip;  Hoerz, Friedrich;  Hurtado, Jose;  Hynek, Brian;  Isaacson, Peter;  Juranek, Catherine;  Klaus, Kurt;  Kring, David;  Lanza, Nina;  Lederer, Susan;  Lofgren, Gary;  Marinova, Margarita;  May, Lisa;  Meyer, Jonathan;  Ming, Doug;  Monteleone, Brian;  Morisset, Caroline;  Noble, Sarah;  Rampe, Elizabeth;  Rice, James;  Schutt, John;  Skinner, James;  Tewksbury-Christle, Carolyn M.;  Tewksbury, Barbara J.;  Vaughan, Alicia;  Yingst, Aileen;  Young, Kelsey
收藏  |  浏览/下载：29/0  |  提交时间：2019/11/29
Planetary surface operations  Analog testing  Science operations  Planetary science  Metric evaluation