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| Systems-level genetic patterns underlying disseminated coccidioidomycosis in humans 项目
项目编号: 1R21AI152394-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: LUSSIER, YVES A.
  收藏 | 浏览/下载：28/0 | 提交时间：2021/08/12
Acute Address adverse outcome African American Alleles Automobile Driving Biochemical Biological Biological Process Biology bone Brain Candidate Disease Gene Caring Case Study Categories causal variant Chronic Clinical clinical care Coccidioides Coccidioidomycosis Code cohort Communicable Diseases Complex Data Databases desert fever design Disease Disease susceptibility DNA Emerging Communicable Diseases Equilibrium Exogenous Factors exome exome sequencing experience Filipino flu Foundations fungus Gene Expression Gene Mutation Genes Genetic genetic architecture Genetic Heterogeneity Genetic Predisposition to Disease genetic risk factor Genetic Variation genome-wide genome-wide analysis Genotype genotyped patients Guidelines Haplotypes Heterogeneity high risk HLA Antigens Human Human Genetics human leukocyte antigen testing IFNGR1 gene IL12RB1 gene Immune Immune response Immune system Immunocompetent Immunogenetics Immunological Models Immunosuppression Infection Inhalation insight Knowledge Life Lung Medical Modeling Molecular Mutation Mycoses National Institute of Allergy and Infectious Disease novel Organ Participant pathogen pathogen exposure Pathogenesis pathogenic fungus Pathology Pathway Analysis Pathway interactions Patients Pattern Phenotype Play Pneumonia Positioning Attribute Predisposition Proteins Quantitative Trait Loci rare variant Recommendation recruit Resistance Resources response Risk risk variant Role Sample Size Sampling Studies Signal Transduction Skin Soil STAT1 gene STAT3 gene Stimulus Symptoms System Systems Analysis Testing Therapeutic Time Variant whole genome |
| Understanding the natural Coccidioides bioaerosol in time and space and its relationship to disease 项目
项目编号: 1R21AI149660-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2022
负责人: ENGELTHALER, DAVID M
收藏 | 浏览/下载：25/0 | 提交时间：2021/08/12
Address Aerosols Affect Air air filter air sampling Animals Area beta diversity Biological Assay Canis familiaris Climate climate change Coccidioides Coccidioidomycosis Collection Communities Community Health Data desert fever Detection Development Disease disease natural history disorder risk DNA Dust Ecology Environment Environmental Monitoring Environmental Risk Factor Environmental Wind epidemiologic data Epidemiology Event exposed human population Exposure to Fungal DNA Fungal Spores fungus Genomics Health Health Care Costs healthcare community Human Human Activities Humidity Incidence Infection Inhalation Knowledge knowledge base Locales Location Meteorology metropolitan microbiome analysis Modeling Monitor Morbidity - disease rate Movement Multivariate Analysis mycobiome Nature novel strategies Outcome Particulate Matter pathogen pathogenic fungus Pattern Population Precipitation predictive modeling Prevalence process optimization prospective Public Health Recreation Research Research Personnel Risk Risk Factors risk mitigation Schools severe weather Site Soil Source Southwestern United States Spatial Distribution suburb System Temperature The science of Mycology Time Veterinarians Weather whole genome Work Workplace |
| Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum 项目
项目编号: 1R01AI148561-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2025
负责人: RAPPLEYE, CHAD A
收藏 | 浏览/下载：38/0 | 提交时间：2021/08/12
Address alpha ketoglutarate Amino Acid Permease Amino Acid Transporter Amino Acids Attenuated base Carbon Catabolism Cells Citric Acid Cycle Coccidioidomycosis Complement Consumption Data desert fever Diagnosis Disease Environment Enzymes Funding Opportunities fungus Genes Genetic Genetic Screening Genetic screening method Genetic Transcription Genus Hippocampus Gluconeogenesis Glutamate Dehydrogenase Glutamates Glycolysis Goals Growth Histoplasma Histoplasma capsulatum Histoplasmosis Immune system Immunocompetent Immunocompromised Host Impairment In Vitro in vivo Individual Infection Innate Immune System interdisciplinary approach Invaded Investigation Isotope Labeling Lung Lung diseases macrophage Measurement Metabolic Metabolic Pathway metabolic profile Metabolism metabolomics Mitochondria Molecular Molecular Biology Molecular Genetics mouse model mutant Mutation Mycoses new therapeutic target novel strategies novel therapeutics Nutrient Nutritional Nutritional Requirements parasitism pathogen Pathogenesis pathogenic fungus Pathway interactions Peptides Phagocytes Phagosomes prevent Proliferating Reaction residence Resources Respiration response RNA Interference Saccharomyces cerevisiae Source Substrate Specificity Systemic disease Testing Therapeutic Time transcriptomics uptake Virulence Yeasts |
| MDIBL Symposium on Stem Cells and Aging 项目
项目编号: 1R13AG069520-01. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2023
负责人: DRUMMOND, IAIN A. (contact); ROGERS, ARIC N
收藏 | 浏览/下载：51/0 | 提交时间：2021/08/12
Address Age aged Aging Animals Area Atmosphere base Biological Biology Blood Cells Brain Caloric Restriction career Cell Aging Cell Communication cell regeneration Cells Cellular Metabolic Process Collaborations Communities comparative Discipline DNA Damage Engineering Epigenetic Process Equilibrium Faculty Failure Fishes fly Generations Genetic Transcription graduate student Human Immersion Inflammation Inflammatory Injury innovation Island Knowledge Laboratories Longevity Lung Maine Maintenance Medical center meetings Mus Muscle Mutation Natural regeneration novel strategies Organ Organ failure Outcome Pathology Postdoctoral Fellow posters programs regenerative Rejuvenation Research Research Institute Research Personnel research study Scientific Advances and Accomplishments Scientist Series Signal Transduction Skin stem cell niche Stem Cell Research stem cells symposium System The Jackson Laboratory tissue regeneration Tissues tissue stem cells Training |
| Understanding the role of thyroid hormone signaling during axolotl limb regeneration 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2020-2023
负责人: MURAWALA, PRAYAG
收藏 | 浏览/下载：21/0 | 提交时间：2021/08/12
Address Adolescent Aging Ambystoma Ambystoma mexicanum Animals Behavior Biological Metamorphosis cell type Comparative Biology Coupled Data evidence base experimental study Fibroblasts hormonal signals Life limb regeneration Literature Mammals Molecular Mus Natural regeneration Organ Organism Organogenesis Pathway interactions Property Rana regenerative Regenerative response Role Series Signal Transduction Testing Thyroid Gland Thyroid Hormones Thyroxine tissue regeneration tissue repair Tissues |
| Project 1 - Environmental Project 1 - EP1 - Immobilization of U, As, and Co-occurring Metals in Mine Wastes 项目
项目编号: 5P42ES025589-04. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: CERRATO, JOSE MANUEL
收藏 | 浏览/下载：34/0 | 提交时间：2021/08/12
Address Adsorption Aerobic Affect Amendment aqueous Basic Science bioaccumulation Biological Carbonates Characteristics Chemicals Chemistry Climate Climate Controls Collaborations Communities Complement contaminated drinking water cultural values Custom Decision Making Desert Climate Development Ecology Engineering Environment Environmental Engineering technology Environmental Microbiology experience experimental study Exposure to Exudate Geographic Factor Goals Hazardous Substances Hazardous Waste Sites Health Home environment Human IGFBP2 gene Immobilization In Vitro Individual Ingestion innovation inorganic phosphate interfacial Intervention iron oxide Knowledge Laboratories Ligands mathematical model Measures member metagenome Metal exposure metal poisoning Metals Methods microbiome microbiome alteration microorganism Microscopy migration Minerals Mining Modeling Molecular Native Americans Navajo New Mexico next generation sequencing Outcomes Research Oxides Pattern Phase Pilot Projects Plant Roots Plants Play Population Precipitation prevent Process programs Pueblo Race Rain Reaction remediation Research Resources Risk Risk Reduction Role Sampling Science Scientist Seasons Site Soil Source Spectrum Analysis Superfund Surface System Techniques Testing tool Toxic effect toxic metal tribal community tribal lands Tribes Underserved Population Universities uptake Uranium wasting Water water flow |
| Project 2 - Macrophage regulation of fibrosis and scarring during tissue regeneration 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: GODWIN, JAMES W
收藏 | 浏览/下载：29/0 | 提交时间：2021/08/12
Address Adult Aging Animal Model Antigens Biological Assay Biological Models Brain Carbohydrates Cell Proliferation cell type Cells cellular targeting Cessation of life Cicatrix Comparative Biology Complex crosslink Development Disease Enzymes Epithelial Epithelial Cells Epithelium Exposure to Extracellular Matrix Fibroblasts Fibrosis Gene Expression Gene Expression Profile Genes Goals healing Healthcare Heart Human human tissue Immune Infection Infiltration Injury Innate Immune System innovation insight Label Laboratories Leukocytes limb amputation limb regeneration Limb structure Liver Lung macrophage Mammals Measures Mediating Mesenchymal Methods Modernization Molecular Myofibroblast Natural regeneration novel Operative Surgical Procedures Organ overexpression Patients Pattern Pharmacology Phenotype Play prevent Process progenitor programs Protein-Lysine 6-Oxidase Proteins PTPRC gene Recovery of Function regenerative regenerative therapy Regulation repaired RNA Interference Role Salamander Signal Pathway Signal Transduction Site Source Spinal Cord Stem cells Surface Testing therapy development Time time use tissue regeneration tissue repair Tissues tool transcriptome sequencing transdifferentiation Traumatic injury wound Wound Healing |
| Project 1 - Disruption of CpG island-mediated gene regulation and chromatin architecture in progeria and aging 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: BECK, SAMUEL
收藏 | 浏览/下载：25/0 | 提交时间：2021/08/12
Address Age of Onset age related Aging Architecture Atherosclerosis Biological Biology of Aging Biomedical Research Blindness Cardiac Myocytes Cell Differentiation process Cells Chromatin Chromosome Mapping Comparative Biology CpG Islands CRISPR/Cas technology Cytosine Data Set de novo mutation Defect Degenerative Disorder Dinucleoside Phosphates Disease DNA DNA Damage DNA Repair Economics Elements epigenetic regulation Euchromatin Fatty Liver Fluorescent in Situ Hybridization Frequencies Gene Expression Gene Expression Regulation Genes Genetic Genetic Transcription genome editing genome-wide Genomic Instability Goals Guanine Hair Hepatocyte Heterochromatin Impairment induced pluripotent stem cell innovation inorganic phosphate insight Lamin Type A Lamins Life Life Expectancy Link Mediating Meta-Analysis Modeling Molecular Morphology mRNA sequencing Musculoskeletal Mutation Natural regeneration Nuclear Nuclear Lamin Nuclear Lamina Pathology Patients Peripheral Physiological Predisposition prevent Process Progeria promoter Property Proteins Psyche structure Public Health Regulation Resources response restoration Skin Structural Protein Symptoms Testing therapy development tissue repair Tissues Undifferentiated |
| Project 3 - Defining the role of ribosome protein composition in regulating the selective translation of pro-longevity genes 项目
项目编号: 5P20GM104318-08. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: ROLLINS, JAROD ALTON
收藏 | 浏览/下载：20/0 | 提交时间：2021/08/12
Address Adult Affect Age age related Aging aging gene Animal Model Animals Biology of Aging Caenorhabditis elegans Caloric Restriction Cardiovascular Diseases Chronic Comparative Biology Cost of Illness CRISPR/Cas technology Data Databases Development differential expression Disease Drosophila genus Exposure to Gene Expression Genes Genetic genetic manipulation Genetic Models Genetic Transcription Genetic Translation Genome engineering Goals Health Health Expenditures healthy aging High-Throughput RNA Sequencing Human innovation insight Invertebrates knock-down Life Longevity longevity gene Malignant Neoplasms Mass Spectrum Analysis Mediating Messenger RNA middle age Molecular Molecular Machines mRNA sequencing Mus Natural regeneration Nerve Degeneration novel overexpression Pathway interactions Pharmacologic Substance Polyribosomes polysome profiling prevent Process Proteins Proteomics Ribosomal Proteins Ribosomes Risk Factors RNA Interference Role stressor Testing therapy development Time tissue repair Transcript transcriptomics Translating Translations Vertebrates Yeasts |
| Administrative Core 项目
项目编号: 5P20GM103423-20. 资助机构: US-NIH（美国国立卫生研究院）. 起止日期: 2019-
负责人: COFFMAN, JAMES A
收藏 | 浏览/下载：16/0 | 提交时间：2021/08/12
Address Administrator Advisory Committees American Association for the Advancement of Science Benchmarking Bioinformatics Biomedical Research Brain Drains Brain Stem Budgets Businesses career career development Centers of Research Excellence Clinical Collaborations Committee Members Communication Research comparative Consultations Development Economics Effectiveness Employment Ensure Evaluation Faculty First Generation College Students formative assessment Fostering functional genomics Goals Grant Hand Health Sciences Human Resources Individual Infrastructure innovation Institution Internships Leadership Logistics Maine meetings Mentors National Institute of General Medical Sciences New England Occupations outreach outreach program Participant Pilot Projects Principal Investigator Private Sector Privatization Procedures Process Program Development Program Research Project Grants programs Research research and development Research Infrastructure Research Personnel Research Project Grants Research Training Resource Sharing Resources Retirement Shapes student mentoring Students success Teacher Professional Development Training Training Activity Training and Infrastructure Training Programs undergraduate student Work |
