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Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosis 项目
项目编号: 1R21AI149015-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2021
负责人:  HUNG, CHIUNG YU
收藏  |  浏览/下载:27/0  |  提交时间:2021/08/12
acute infection  Adverse effects  Affect  Americas  Amphotericin B  Animals  Antifungal Agents  Antimicrobial Resistance  Area  base  Biological Assay  Caliber  Caspofungin  Cell Membrane Permeability  Cell Wall  Cells  chemotherapy  Clinical  Coccidioides  Coccidioides immitis  Coccidioides posadasii  Coccidioidomycosis  Communities  Containment  Contracts  cost  Cryptococcus  Cryptococcus neoformans  Cytochrome P450  Cytology  cytotoxicity  Data  Databases  desert fever  Development  Diagnosis  Disease  Dose  drug development  Drug usage  drug use screening  Flow Cytometry  Fluconazole  follow-up  fungus  Goals  Government  Growth  Hand  Human  Hyphae  Image  In Vitro  in vivo  Incubated  indexing  Infection  Inhalation  insight  Lead  Legal patent  Libraries  Life Cycle Stages  Lower respiratory tract structure  Lung  Lung diseases  Medical  Medical Research  Meningitis  Methods  Mexico  Microscope  Morphology  Motivation  Mycoses  Neuraxis  novel  novel strategies  novel therapeutics  off-patent  pathogen  pathogenic fungus  Patients  Pharmaceutical Preparations  Pharmacology  Phase IV Clinical Trials  Phenotype  Pneumonia  preclinical development  prevent  Process  Property  Reporting  Reproduction spores  Research Personnel  resistant strain  Resolution  screening  small molecule libraries  Soil  South America  Southwestern United States  Speed  success  Symptoms  synergism  Techniques  Testing  The science of Mycology  Time  Toxic effect  United States  United States National Institutes of Health  Vaccines  
Intracellular Proliferation of the fungal pathogen Histoplasma capsulatum 项目
项目编号: 1R01AI148561-01. 资助机构: US-NIH(美国国立卫生研究院). 起止日期: 2020-2025
负责人:  RAPPLEYE, CHAD A
收藏  |  浏览/下载:40/0  |  提交时间:2021/08/12
Address  alpha ketoglutarate  Amino Acid Permease  Amino Acid Transporter  Amino Acids  Attenuated  base  Carbon  Catabolism  Cells  Citric Acid Cycle  Coccidioidomycosis  Complement  Consumption  Data  desert fever  Diagnosis  Disease  Environment  Enzymes  Funding Opportunities  fungus  Genes  Genetic  Genetic Screening  Genetic screening method  Genetic Transcription  Genus Hippocampus  Gluconeogenesis  Glutamate Dehydrogenase  Glutamates  Glycolysis  Goals  Growth  Histoplasma  Histoplasma capsulatum  Histoplasmosis  Immune system  Immunocompetent  Immunocompromised Host  Impairment  In Vitro  in vivo  Individual  Infection  Innate Immune System  interdisciplinary approach  Invaded  Investigation  Isotope Labeling  Lung  Lung diseases  macrophage  Measurement  Metabolic  Metabolic Pathway  metabolic profile  Metabolism  metabolomics  Mitochondria  Molecular  Molecular Biology  Molecular Genetics  mouse model  mutant  Mutation  Mycoses  new therapeutic target  novel strategies  novel therapeutics  Nutrient  Nutritional  Nutritional Requirements  parasitism  pathogen  Pathogenesis  pathogenic fungus  Pathway interactions  Peptides  Phagocytes  Phagosomes  prevent  Proliferating  Reaction  residence  Resources  Respiration  response  RNA Interference  Saccharomyces cerevisiae  Source  Substrate Specificity  Systemic disease  Testing  Therapeutic  Time  transcriptomics  uptake  Virulence  Yeasts  
Sustainability Challenges for Maize and Cassava Farmers in Amankwakrom Subdistrict, Ghana 学位论文
学位授予机构: ScholarWorks. 出版年: 2016
作者:  Atadja;Franklin Komla
收藏  |  浏览/下载:39/0  |  提交时间:2019/11/29
Agriculture financing strategies  Hunger and poverty reduction  Land tenure systems  Management  Stimulated economic growth  Business  Other Education  
Mechanisms for maintenance of dominance in a nonclonal desert shrub 期刊论文
发表期刊: ECOSPHERE. 出版年: 2015, 卷号: 6, 期号: 12
作者:  Kitchen, Stanley G.;  Meyer, Susan E.;  Carlson, Stephanie L.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/29
age structure  blackbrush  Coleogyne ramosissima  Colorado Plateau  dendrochronology  growth rate  life-history strategies  masting  Mojave Desert  seedling bank  stress tolerance  
Clonal Growth Forms in Eastern Ladakh, Western Himalayas: Classification and Habitat Preferences 期刊论文
发表期刊: FOLIA GEOBOTANICA. 出版年: 2011, 卷号: 46, 期号: 2-3, 页码: 191-217
作者:  Klimesova, Jitka;  Dolezal, Jiri;  Dvorsky, Miroslav;  de Bello, Francesco;  Klimes, Leos
收藏  |  浏览/下载:23/0  |  提交时间:2019/11/29
Altitude  Classification  Clonal growth form  Clonal space occupancy strategies  Habitat types  Ladakh  
Priority Research and Management Issues for the Imperiled Great Basin of the Western United States 期刊论文
发表期刊: RESTORATION ECOLOGY. 出版年: 2009, 卷号: 17, 期号: 5, 页码: 707-714
作者:  Chambers, Jeanne C.;  Wisdom, Michael J.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/28
altered fire regimes  human population growth  invasive species  land degradation  research and management strategies  semiarid regions  
Games roots play: effects of soil volume and nutrients 期刊论文
发表期刊: JOURNAL OF ECOLOGY. 出版年: 2008, 卷号: 96, 期号: 3, 页码: 438-446
作者:  O’Brien, Erin E.;  Brown, Joel S.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/28
nutrient concentration  plant competition  plant growth strategies  root communication  root interactions  soil volume  Tragedy of the Commons  
Management of rangeland livestock under drought 期刊论文
发表期刊: ANNALS OF ARID ZONE. 出版年: 2002, 卷号: 41, 期号: 1, 页码: 1-23
作者:  Horn, BE;  Hart, CR;  Paisley, SI
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/28
drought  plant growth  rangeland management  forage demand  drought planning  destocking strategies  early weaning  feeding management  alternative feeds  
Responding to a three-pronged attack: desert lilies subject to herbivory by dorcas gazelles 期刊论文
发表期刊: PLANT ECOLOGY. 出版年: 2000, 卷号: 148, 期号: 2, 页码: 127-138
作者:  Saltz, D;  Ward, D
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/28
herbivory  coevolution  lilies  plant defences  desert  Israel  gazelles  growth strategies