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Combine and conquer: manganese synergizing anti-TGF-beta/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers 期刊论文
发表期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY. 出版年: 2021, 卷号: 14, 期号: 1
作者:  Yi, Ming;  Niu, Mengke;  Zhang, Jing;  Li, Shiyu;  Zhu, Shuangli;  Yan, Yongxiang;  Li, Ning;  Zhou, Pengfei;  Chu, Qian;  Wu, Kongming
收藏  |  浏览/下载:57/0  |  提交时间:2021/11/19
The tumor microenvironment  Manganese  cGAS-STING  PD-L1  TGF-beta  Bispecific antibody  Cancer immunotherapy  
胃癌中TGF-beta、PD-L1表达与肿瘤免疫表型的关系及其临床意义 期刊论文
发表期刊: 中国现代应用药学. 出版年: 2021, 卷号: 38, 期号: 9, 页码: 1007-7693
作者:  张竞舟;  胡楠;  汤佳琦;  洪义东;  卞保祥;  宋子琰;  吴风雷
收藏  |  浏览/下载:63/0  |  提交时间:2021/11/19
TGF-beta  PD-L1  gastric cancer  ICB  cancer-immune phenotypes  TGF-beta  PD-L1  
Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling 期刊论文
发表期刊: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 出版年: 2020, 卷号: 393, 期号: 3, 页码: 303-313
作者:  Maghmomeh, Abdalkareem Omar;  El-Gayar, Amal Mohamed;  El-Karef, Amro;  Abdel-Rahman, Noha
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/29
Kidney fibrosis  Hedgehog pathway  TGF-beta 1  Arsenic trioxide  Curcumin  
OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro 期刊论文
发表期刊: EPIGENETICS. 出版年: 2014, 卷号: 9, 期号: 12, 页码: 1626-1640
作者:  Rose, Michael;  Schubert, Claudia;  Dierichs, Laura;  Gaisa, Nadine T.;  Heer, Matthias;  Heidenreich, Axel;  Knuechel, Ruth;  Dahl, Edgar
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/29
bladder cancer  HTRA3  OASIS  CREB3L1  promoter methylation  tumor cell migration  tumor suppressor gene  ATCC  American Type Culture Collection  BMP-2  bone morphogenetic protein 2  CA  California  cDNA  copy number desoxyribonucleic acid  CIS  Carcinoma in situ  CREB3L1  element binding protein 3-like 1  DAB  3-3 diaminobenzidine  DAC  5-aza-2-deoxycytidine  DNA  desoxyribonucleic acid  EK  ethics committee  ER  endoplasmic reticulum  FC  fold change  FFPE  formalin fixed paraffin embedded  G1  well differentiated  G2  moderately differentiated  G3  poorly differentiated  GAPDH  glyceraldehyde 3-phosphate dehydrogenase  HCV  Hepatitis C virus  HPV  human papilloma virus  HTRA (1-4)  high-temperature requirement factor A (1-4)  IQR  interquartile range  IRS  immunoreactive score  LMU  Ludwig-Maximilians-University  M  methylated  MIBC  muscle invasive bladder cancer  mRNA  messenger ribo nucleic acid  MSP  methylation specific PCR  n  number  NMIBC  non-muscle invasive bladder cancer  ns  not significant  NU  normal urothelium  OASIS  old astrocyte specifically-induced substance  PCR  polymerase chain reaction  pTa  papillary non-invasive tumors  RIP  regulated intramembrane proteolysis  RWTH  Rheinisch Westfalisch Technische Hochschule  s  e  m  standard error of the margin  SP1  site 1 protease  SP2  site 2 protease  TCGA  The Cancer Genome Atlas  TGF-  transforming growth factor beta  TSA  trichostatin A  TSS  transcription start site  U  unmethylated  UC  urothelial cell cancer  UPR  unfold protein response  USA  United States of America  WHO  World Health Organization  WI  Wisconsin  
Transforming growth factor-beta 1 in a sterilized tissue derived from the pig small intestine submucosa 期刊论文
发表期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 出版年: 2003, 期号: 2, 页码: 637-640
作者:  McDevitt, CA;  Wildey, GM;  Cutrone, RM
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/28
TGF-beta 1  growth factors  wound dressing  sterilization  extracellular matrix