干旱区生态环境知识资源中心(Arid): Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling

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DOI	10.1007/s00210-019-01734-y
	Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling
	Maghmomeh, Abdalkareem Omar 1,2; El-Gayar, Amal Mohamed 1; El-Karef, Amro 3; Abdel-Rahman, Noha 1
通讯作者	Abdel-Rahman, Noha
来源期刊	NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
ISSN	0028-1298
EISSN	1432-1912
出版年	2020
卷号	393 期号:3 页码:303-313
英文摘要	Renal fibrosis is a progressive process resulting from a sustained injury that may ultimately cause renal failure. Cisplatin is an antitumor drug that induces renal injury and nephrotoxicity and is widely employed as a model for acute and chronic renal injury. Several signaling pathways are implicated in fibrogenic cell activation among which is Hedgehog (Hh) signaling. We here investigated the effects of arsenic trioxide (Ars) and curcumin in ameliorating cisplatin-induced kidney fibrosis via regulating Hh signaling. Cisplatin (4.5 mg/kg) was administered in Sprague-Dawley rats for two consecutive days and renal fibrosis was induced after 21 days. Once renal fibrosis was confirmed, Ars (3.5 mg/kg/day, orally) and curcumin (200 mg/kg/day, orally) were administered daily for another 21 days. Ars and curcumin corrected kidney function markers as creatinine clearance and urea nitrogen. Both agents ameliorated fibrosis as shown by lowered TGF-beta 1 mRNA levels, alpha-SMA protein levels, and hydroxylproline content. Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels. Our results indicate new therapeutic roles for Ars and curcumin and suggest that blocking Hh signaling may be a promising approach for alleviating renal fibrosis. Symbols indicate alpha-SMA, alpha-smooth muscle actin; TGF-beta, transforming growth factor-beta; Ptch, patched; Smo, smoothened; Shh, sonic hedgehog; Ihh, Indian hedgehog; Dhh, desert hedgehog; and SUFU, suppressor of fused.
英文关键词	Kidney fibrosis Hedgehog pathway TGF-beta 1 Arsenic trioxide Curcumin
类型	Article
语种	英语
国家	Egypt
收录类别	SCI-E
WOS记录号	WOS:000489925200001
WOS关键词	CHRONIC KIDNEY-DISEASE ; MESENCHYMAL STEM-CELLS ; GROWTH-FACTOR-BETA ; SONIC HEDGEHOG ; IN-VITRO ; PATHWAY ACTIVATION ; PULMONARY-FIBROSIS ; URINARY BIOMARKER ; CANCER CELLS ; INJURY
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/217761
作者单位	1.Univ Mansoura, Dept Biochem, Fac Pharm, Mansoura 35516, Egypt; 2.Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Int Coastal Rd, Mansoura 35712, Egypt; 3.Univ Mansoura, Dept Pathol, Fac Med, Mansoura 35516, Egypt
推荐引用方式 GB/T 7714	Maghmomeh, Abdalkareem Omar,El-Gayar, Amal Mohamed,El-Karef, Amro,et al. Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling[J],2020,393(3):303-313.
APA	Maghmomeh, Abdalkareem Omar,El-Gayar, Amal Mohamed,El-Karef, Amro,&Abdel-Rahman, Noha.(2020).Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling.NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,393(3),303-313.
MLA	Maghmomeh, Abdalkareem Omar,et al."Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling".NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 393.3(2020):303-313.