干旱区生态环境知识资源中心(Arid): Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis

Arid

DOI	10.1038/s41598-024-53384-7
	Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis
	Liu, Shuyue; Zhao, Kai; Shao, Chunhong; Xu, Lulu; Cui, Xianglun; Wang, Yong
通讯作者	Wang, Y
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2024
卷号	14 期号:1
英文摘要	The alkaline phosphatase-to-albumin ratio (APAR) is correlated to worse prognosis in coronary artery disease, cancer, and acute renal failure. However, the relationship between APAR and sepsis prognosis has received little research. The content of this research was to investigate the prognostic relationship between APAR and sepsis. And validate the stability of the correlation in 90-days and 1-year mortality. Retrospective cohort research was conducted basing MIMIC-IV database (version 2.0). The hazard ratio (HR) and 95% confidence interval (Cl) were computed using multivariate Cox regression analysis. In addition, plots of survival curves and subgroup analyzes were conducted. Receiver operating characteristic (ROC) curves were also used. 9741 participants were included in this investigation. The 90-days mortality was 32.8%, and the 1-year mortality was 42.0%. After controlling for confounders, the adjusted HRs (95% CI) for tertile 2 (2.2-3.8) and tertile 3 (> 3.8) were 1.37 (1.25-1.51) and 1.74 (1.58-1.91), respectively. The Kaplan-Meier curve analysis showed a higher probability of 90-days death in the higher APAR group. The area under the curve (AUC) of APAR was 0.674 and could reach 0.709 after combining the Oxford Acute Severity of Illness Score (OASIS). This study demonstrates that APAR is significantly related to bad clinical outcomes in sepsis.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001158921600019
WOS关键词	ACUTE KIDNEY INJURY ; SERUM-ALBUMIN
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/405609
推荐引用方式 GB/T 7714	Liu, Shuyue,Zhao, Kai,Shao, Chunhong,et al. Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis[J],2024,14(1).
APA	Liu, Shuyue,Zhao, Kai,Shao, Chunhong,Xu, Lulu,Cui, Xianglun,&Wang, Yong.(2024).Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis.SCIENTIFIC REPORTS,14(1).
MLA	Liu, Shuyue,et al."Association between alkaline phosphatase to albumin ratio and mortality among patients with sepsis".SCIENTIFIC REPORTS 14.1(2024).