干旱区生态环境知识资源中心(Arid): Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis

Arid

DOI	10.1038/s41598-024-54574-z
	Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
	Huang, Zhifeng; Li, Aoli; Zhu, Huiqing; Pan, Junxiu; Xiao, Jun; Wu, Jiang; Han, Yumin; Zhong, Lili; Sun, Xuhui; Wang, Lei; Hu, Liang; Wang, Cuihua; Ma, Xingkai; Qiao, Zaixia; Zhang, Min; Yuan, Ling; Liu, Xin; Tang, Jun; Li, Yue; Yu, Hong; Zheng, Zhaobing; Sun, Baoqing
通讯作者	Sun, BQ
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2024
卷号	14 期号:1
英文摘要	This study is nationwide multicenter epidemiological research, aimed at investigating the distribution changes and seasonal patterns of various airborne allergens among preschool children with allergic rhinitis (AR) in different regions of China, and analyzing the clinical correlation between sensitization to various airborne allergens and AR symptoms in children. Information on children was collected through standard questionnaires, and total IgE (tIgE) and specific IgE (sIgE) for 11 inhalant allergens were tested. The results showed that dust mites are the primary allergens for preschool AR children (39%). Among pollen allergens, Amb a had the highest positivity rate (8.1%), followed by Art v (7.8%). The sensitization rates for two mites peaked in May (46.9% and 40.6%). Art v peaked in August (21.5%), while Amb a had peaks in May (12.7%) and August (17.8%). The sensitization peaks for various tree pollens mainly occurred in August. In the Eastern monsoon region, the sensitization rate to mites was significantly higher than in the Northwest arid and semi-arid regions; whereas, for pollen allergens, the sensitization rates to Amb a, Pla a, Pin a, Pop d, and Bet v were significantly higher in the Northwest arid and semi-arid regions than in the Eastern monsoon region. The correlation among various tree pollens, specifically between Pla a, Pin r, Pop d, and Bet v was strong (0.63 similar to 0.79), with a cross-overlapping percentage of 53.9%. Children with multiple pollen sensitizations had higher cumulative nasal symptom scores than those negative for pollen (P < 0.01). Children with only pollen sensitization had higher cumulative rhinitis symptom scores than the all-negative group (P < 0.0001) and the mite-only sensitization group [P < 0.05], while the mite-only sensitization group also had higher scores than the all-negative group [P < 0.05], and the group sensitized to both pollen and mites had lower scores than the pollen-only group [P < 0.05]. This study indicates that sensitization to mites and grass pollens exhibits significant regional differences, with grass pollen allergies primarily occurring in autumn, sensitization to pollens in general exhibits a pronounced seasonal pattern. Moreover, pollen sensitization aggravates nasal and ocular symptoms in AR children.
英文关键词	Preschool Allergic rhinitis House dust mite Pollen Regional differences Epidemiology
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001177603900094
WOS关键词	RISK-FACTORS ; EPIDEMIOLOGY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/405577
推荐引用方式 GB/T 7714	Huang, Zhifeng,Li, Aoli,Zhu, Huiqing,et al. Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis[J],2024,14(1).
APA	Huang, Zhifeng.,Li, Aoli.,Zhu, Huiqing.,Pan, Junxiu.,Xiao, Jun.,...&Sun, Baoqing.(2024).Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis.SCIENTIFIC REPORTS,14(1).
MLA	Huang, Zhifeng,et al."Multicenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis".SCIENTIFIC REPORTS 14.1(2024).