干旱区生态环境知识资源中心(Arid): A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals

Arid

DOI	10.1371/journal.pone.0286899
	A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals
	Garland, McKenna M.; Wilson, Raminta; Thompson, Wesley K.; Stein, Murray B.; Paulus, Martin P.; Feinstein, Justin S.; Khalsa, Sahib S.
通讯作者	Khalsa, SS
来源期刊	PLOS ONE
ISSN	1932-6203
出版年	2024
卷号	19 期号:6
英文摘要	Background Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Prior studies in anxious and depressed individuals demonstrated that single sessions of floatation-REST are safe, well-tolerated, and associated with an acute anxiolytic and antidepressant effect that persists for over 48 hours. However, the feasibility of using floatation-REST as a repeated intervention in anxious and depressed populations has not been well-investigated.Methods In this single-blind safety and feasibility trial, 75 individuals with anxiety and depression were randomized to complete six sessions of floatation-REST in different formats: pool-REST (weekly 1-hour float sessions), pool-REST preferred (float sessions with flexibility of duration and frequency), or an active comparator (chair-REST; weekly 1-hour sessions in a Zero Gravity chair). Feasibility (primary outcome) was assessed via an 80% rate of adherence to the assigned intervention; tolerability via study dropout and duration/frequency of REST utilization; and safety via incidence of adverse events and ratings about the effects of REST.Results Of 1,715 individuals initially screened, 75 participants were ultimately randomized. Six-session adherence was 85% for pool-REST (mean, M = 5.1 sessions; standard deviation, SD = 1.8), 89% for pool-REST preferred (M = 5.3 sessions; SD = 1.6), and 74% for chair-REST (M = 4.4 sessions; SD = 2.5). Dropout rates at the end of the intervention did not differ significantly between the treatment conditions. Mean session durations were 53.0 minutes (SD = 12.3) for pool-REST, 75.4 minutes (SD = 29.4) for pool-REST preferred, and 58.4 minutes (SD = 4.3) for chair-REST. There were no serious adverse events associated with any intervention. Positive experiences were endorsed more commonly than negative ones and were also rated at higher levels of intensity.Conclusions Six sessions of floatation-REST appear feasible, well-tolerated, and safe in anxious and depressed individuals. Floatation-REST induces positively-valenced experiences with few negative effects. Larger randomized controlled trials evaluating markers of clinical efficacy are warranted.Clinical Trial Registration Identifier NCT03899090.
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001241954400061
WOS关键词	ENVIRONMENTAL STIMULATION TECHNIQUE ; IMPAIRMENT SCALE OASIS ; ANXIETY SEVERITY ; PSYCHOMETRIC PROPERTIES ; SENSORY DEPRIVATION ; EXPOSURE THERAPY ; METAANALYSIS ; COMORBIDITY ; DISORDERS ; CREDIBILITY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/405191
推荐引用方式 GB/T 7714	Garland, McKenna M.,Wilson, Raminta,Thompson, Wesley K.,et al. A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals[J],2024,19(6).
APA	Garland, McKenna M..,Wilson, Raminta.,Thompson, Wesley K..,Stein, Murray B..,Paulus, Martin P..,...&Khalsa, Sahib S..(2024).A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals.PLOS ONE,19(6).
MLA	Garland, McKenna M.,et al."A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals".PLOS ONE 19.6(2024).