干旱区生态环境知识资源中心(Arid): Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity

Arid

DOI	10.3390/plants13101409
	Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity
	Arrieche, Dioni; Olea, Andres F.; Jara-Gutierrez, Carlos; Villena, Joan; Pardo-Baeza, Javier; Garcia-Davis, Sara; Viteri, Rafael; Taborga, Lautaro; Carrasco, Hector
通讯作者	Taborga, L
来源期刊	PLANTS-BASEL
ISSN	2223-7747
出版年	2024
卷号	13 期号:10
英文摘要	Pintoa chilensis is a shrub with yellow flowers that reach up to two meters high, endemic of the Atacama Region in Chile. This species grows under special environmental conditions such as low altitude, arid areas, and directly sun-exposed habitats. In the present study, ethanolic extract was obtained from fruits of P. chilensis, and then partitioned in solvents of increasing polarity to obtain five fractions: hexane (HF), dichloromethane (DF), ethyl acetate (AF), and the residual water fraction (QF). The antioxidant activity of extracts was evaluated by using the DPPH, ABTS, and FRAP methods. The results show that the antioxidant capacity of P. chilensis is higher than that reported for other plants growing in similar environments. This effect is attributed to the highest content of flavonoids and total phenols found in P. chilensis. On the other hand, the cell viability of a breast cancer cell line (MCF-7) and a non-tumor cell line (MCF-10A) was assessed in the presence of different extract fractions. The results indicate that the hexane fraction (HF) exhibits the highest cytotoxicity on both cell lines (IC50 values equal to 35 and 45 mu g/mL), whereas the dichloromethane fraction (DF) is the most selective one. The GC-MS analysis of the dichloromethane fraction (DF) shows the presence of fatty acids, sugars, and polyols as major components.
英文关键词	extremophile plants Pintoa chilensis cytotoxic activity antioxidant activity lipid peroxidation ROS GC-MS analysis
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001233719500001
WOS关键词	NF-KAPPA-B ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; MEDICINAL-PLANTS ; NATURAL-PRODUCTS ; DESERT PLANTS ; SESQUITERPENE LACTONE ; BIOLOGICAL-ACTIVITIES ; DNA-DAMAGE ; CANCER
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/405151
推荐引用方式 GB/T 7714	Arrieche, Dioni,Olea, Andres F.,Jara-Gutierrez, Carlos,et al. Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity[J],2024,13(10).
APA	Arrieche, Dioni.,Olea, Andres F..,Jara-Gutierrez, Carlos.,Villena, Joan.,Pardo-Baeza, Javier.,...&Carrasco, Hector.(2024).Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity.PLANTS-BASEL,13(10).
MLA	Arrieche, Dioni,et al."Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity".PLANTS-BASEL 13.10(2024).