干旱区生态环境知识资源中心(Arid): Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements

Arid

DOI	10.1002/ppul.27180
	Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements
	Wyler, Florian; Manogaran, Thuvarakha; Monney, Nathalie; Salem, Yasmin; Steinberg, Ruth; Kentgens, Anne-Christianne; Jacobs, Carvern; Chaya, Shaakira; Sena, Carla Rebeca da Silva; Kuenstle, Noemi; Gorlanova, Olga; Yammine, Sophie; Gray, Diane M.; Frey, Urs; Oestreich, Marc-Alexander; Latzin, Philipp
通讯作者	Latzin, P
来源期刊	PEDIATRIC PULMONOLOGY
ISSN	8755-6863
EISSN	1099-0496
出版年	2024
英文摘要	IntroductionMajor methodological issues with the existing algorithm (WBreath) used for the analysis of speed-of-sound-based infant sulfur hexafluoride (SF6) multiple-breath washout (MBW) measurements lead to implausible results and complicate the comparison between different age groups and centers.MethodsWe developed OASIS-a novel algorithm to analyze speed-of-sound-based infant SF6 MBW measurements. This algorithm uses known context of the measurements to replace the dependence of WBreath on model input parameters. We validated the functional residual capacity (FRC) measurement accuracy of this new algorithm in vitro, and investigated its use in existing infant MBW data sets from different infant cohorts from Switzerland and South Africa.ResultsIn vitro, OASIS managed to outperform WBreath at FRC measurement accuracy, lowering mean (SD) absolute error from 5.1 (3.2) % to 2.1 (1.6) % across volumes relevant for the infant age range, in variable temperature, respiratory rate, tidal volume and ventilation inhomogeneity conditions. We showed that changes in the input parameters to WBreath had a major impact on MBW results, a methodological drawback which does not exist in the new algorithm. OASIS produced more plausible results than WBreath in longitudinal tracking of lung clearance index (LCI), provided improved measurement stability in LCI over time, and improved comparability between centers.DiscussionThis new algorithm represents a meaningful advance in obtaining results from a legacy system of lung function measurement by allowing a single method to analyze measurements from different age groups and centers.
英文关键词	lung clearance index OASIS WBreath
类型	Article ; Early Access
语种	英语
开放获取类型	hybrid, Green Accepted
收录类别	SCI-E
WOS记录号	WOS:001270705600001
WOS关键词	LUNG CLEARANCE INDEX
WOS类目	Pediatrics ; Respiratory System
WOS研究方向	Pediatrics ; Respiratory System
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/405037
推荐引用方式 GB/T 7714	Wyler, Florian,Manogaran, Thuvarakha,Monney, Nathalie,et al. Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements[J],2024.
APA	Wyler, Florian.,Manogaran, Thuvarakha.,Monney, Nathalie.,Salem, Yasmin.,Steinberg, Ruth.,...&Latzin, Philipp.(2024).Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements.PEDIATRIC PULMONOLOGY.
MLA	Wyler, Florian,et al."Optimized algorithm for speed-of-sound-based infant sulfur hexafluoride multiple-breath washout measurements".PEDIATRIC PULMONOLOGY (2024).