干旱区生态环境知识资源中心(Arid): Redefining the treponemal history through pre-Columbian genomes from Brazil

Arid

DOI	10.1038/s41586-023-06965-x
	Redefining the treponemal history through pre-Columbian genomes from Brazil
	Majander, Kerttu; Pla-Diaz, Marta; du Plessis, Louis; Arora, Natasha; Filippini, Jose; Pezo-Lanfranco, Luis; Eggers, Sabine; Gonzalez-Candelas, Fernando; Schuenemann, Verena J.
通讯作者	Majander, K ; Schuenemann, VJ
来源期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2024
英文摘要	The origins of treponemal diseases have long remained unknown, especially considering the sudden onset of the first syphilis epidemic in the late 15th century in Europe and its hypothesized arrival from the Americas with Columbus' expeditions1,2. Recently, ancient DNA evidence has revealed various treponemal infections circulating in early modern Europe and colonial-era Mexico3-6. However, there has been to our knowledge no genomic evidence of treponematosis recovered from either the Americas or the Old World that can be reliably dated to the time before the first trans-Atlantic contacts. Here, we present treponemal genomes from nearly 2,000-year-old human remains from Brazil. We reconstruct four ancient genomes of a prehistoric treponemal pathogen, most closely related to the bejel-causing agent Treponema pallidum endemicum. Contradicting the modern day geographical niche of bejel in the arid regions of the world, the results call into question the previous palaeopathological characterization of treponeme subspecies and showcase their adaptive potential. A high-coverage genome is used to improve molecular clock date estimations, placing the divergence of modern T. pallidum subspecies firmly in pre-Columbian times. Overall, our study demonstrates the opportunities within archaeogenetics to uncover key events in pathogen evolution and emergence, paving the way to new hypotheses on the origin and spread of treponematoses. Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.
类型	Article ; Early Access
语种	英语
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:001176944300001
WOS关键词	SALMONELLA-ENTERICA ; PALLIDUM LINEAGES ; SYPHILIS ; SEQUENCE ; CONTEMPORARY ; DIVERSITY ; BEJEL ; YAWS ; HETEROGENEITY ; REEMERGENCE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404961
推荐引用方式 GB/T 7714	Majander, Kerttu,Pla-Diaz, Marta,du Plessis, Louis,et al. Redefining the treponemal history through pre-Columbian genomes from Brazil[J],2024.
APA	Majander, Kerttu.,Pla-Diaz, Marta.,du Plessis, Louis.,Arora, Natasha.,Filippini, Jose.,...&Schuenemann, Verena J..(2024).Redefining the treponemal history through pre-Columbian genomes from Brazil.NATURE.
MLA	Majander, Kerttu,et al."Redefining the treponemal history through pre-Columbian genomes from Brazil".NATURE (2024).