干旱区生态环境知识资源中心(Arid): Fusarium keratitis in a Brazilian tropical semi-arid area: Clinical-epidemiological features, molecular identification and antifungal susceptibility

Arid

DOI	10.1111/myc.13728
	Fusarium keratitis in a Brazilian tropical semi-arid area: Clinical-epidemiological features, molecular identification and antifungal susceptibility
	Milanez, Edlany Pinho Romao; de Souza, Pedro de Freitas Santos Manzi; Monteiro, Ruan Campos; Pereira, Livia Maria Galdino; Peixoto, Paulo Henrique Soares; de Oliveira, Denis Francisco Goncalves; Colares, Pedro Paulo Rodrigues; Teixeira, Raielly Furtado; Andrade, Marilia de Freitas Chaves e; Silva, Jailton Vieira; Rodrigues, Anderson Messias; Maia, Debora Castelo Branco de Souza Collares; Cordeiro, Rossana de Aguiar
通讯作者	Cordeiro, RD
来源期刊	MYCOSES
ISSN	0933-7407
EISSN	1439-0507
出版年	2024
卷号	67 期号:5
英文摘要	Background: Fungal keratitis is a severe eye infection that can result in blindness and visual impairment, particularly in developing countries. Fusarium spp. are the primary causative agents of this condition. Diagnosis of Fusarium keratitis (FK) is challenging, and delayed treatment can lead to serious complications. However, there is limited epidemiological data on FK, especially in tropical areas. Objectives: This study aimed to describe the clinical, laboratorial and epidemiological characteristics of FK in a tropical semi-arid region of Brazil. Patients/Methods: Adult patients with laboratory-confirmed FK diagnosed between October 2019 and March 2022 were evaluated. Fusarium isolates were characterized at molecular level and evaluated regarding antifungal susceptibility. Results: A total of 226 clinical samples from patients suspected of keratitis were evaluated; fungal growth was detected in 50 samples (22.12%); out of which 42 were suggestive of Fusarium spp. (84%). Molecular analysis of a randomly selected set of 27 isolates identified F. solani species complex (n = 14); F. fujikuroi sensu lato (n = 6) and F. dimerum sensu lato (n = 7); a total of 10 haplotypes were identified among the strains. All but one Fusarium strains were inhibited by amphotericin B, natamycin and fluconazole. Most patients were male (71.42%; 30 out of 42), aged from 27 to 73 years old. Trauma was the most important risk factor for FK (40.47%; 17 out of 42). Patients were treated with antifungals, corticoids and antibiotics; keratoplasty and eye enucleation were also performed. Conclusions: The study provided insights into the characteristics of FK in tropical regions and emphasized the importance of enhanced surveillance and management strategies.
英文关键词	fungal keratitis Fusarium dimerum species complex Fusarium fujikuroi species complex Fusarium solani species complex haplotypes
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001258422600001
WOS关键词	FUNGAL KERATITIS ; MICROBIAL KERATITIS ; INFECTIOUS KERATITIS ; CONTACT-LENS ; DIAGNOSIS ; SPECTRUM ; DISEASE ; NORTH
WOS类目	Dermatology ; Mycology
WOS研究方向	Dermatology ; Mycology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404947
推荐引用方式 GB/T 7714	Milanez, Edlany Pinho Romao,de Souza, Pedro de Freitas Santos Manzi,Monteiro, Ruan Campos,et al. Fusarium keratitis in a Brazilian tropical semi-arid area: Clinical-epidemiological features, molecular identification and antifungal susceptibility[J],2024,67(5).
APA	Milanez, Edlany Pinho Romao.,de Souza, Pedro de Freitas Santos Manzi.,Monteiro, Ruan Campos.,Pereira, Livia Maria Galdino.,Peixoto, Paulo Henrique Soares.,...&Cordeiro, Rossana de Aguiar.(2024).Fusarium keratitis in a Brazilian tropical semi-arid area: Clinical-epidemiological features, molecular identification and antifungal susceptibility.MYCOSES,67(5).
MLA	Milanez, Edlany Pinho Romao,et al."Fusarium keratitis in a Brazilian tropical semi-arid area: Clinical-epidemiological features, molecular identification and antifungal susceptibility".MYCOSES 67.5(2024).