干旱区生态环境知识资源中心(Arid): AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer

Arid

DOI	10.1158/1541-7786.MCR-23-0629
	AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer
	Ito, Taichi; Saito, Atsushi; Kamikawa, Yasunao; Nakazawa, Nayuta; Imaizumi, Kazunori
通讯作者	Saito, A ; Imaizumi, K
来源期刊	MOLECULAR CANCER RESEARCH
ISSN	1541-7786
EISSN	1557-3125
出版年	2024
卷号	22 期号:4 页码:373-385
英文摘要	Breast cancer ranks first in incidence and fifth in cancer-related deaths among all types of cancer globally. Among breast cancer, triple-negative breast cancer (TNBC) has few known therapeutic targets and a poor prognosis. Therefore, new therapeutic targets and strategies against TNBC are required. We found that androgen-induced basic leucine zipper (AIbZIP), also known as cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4), which is encoded by Creb3l4, is highly upregulated in a particular subtype of TNBC, luminal androgen receptor (LAR) subtype. We analyzed the function of AIbZIP through depletion of AIbZIP by siRNA knockdown in LAR subtype TNBC cell lines, MFM223 and MDAMB453. In AIbZIP-depleted cells, the proliferation ratios of cells were greatly suppressed. Moreover, G1-S transition was inhibited in AIbZIP-depleted cells. We comprehensively analyzed the expression levels of proteins that regulate G1-S transition and found that p27 was specifically upregulated in AIbZIP-depleted cells. Furthermore, we identified that this p27 downregulation was caused by protein degradation modulated by the ubiquitin-proteasome system via F-box protein S-phase kinase-associated protein 2 (SKP2) upregulation. Our findings demonstrate that AIbZIP is a novel p27-SKP2 pathway-regulating factor and a potential molecule that contributes to LAR subtype TNBC progression.Implications: This research shows a new mechanism for the proliferation of LAR subtype TNBC regulated by AIbZIP, that may provide novel insight into the LAR subtype TNBC progression and the molecular mechanisms involved in cell proliferation.
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:001196169600003
WOS关键词	GENE-EXPRESSION ; CYCLE ; PROGRESSION ; GENOMICS ; PLATFORM ; PATHWAY ; OASIS ; LINE
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404929
推荐引用方式 GB/T 7714	Ito, Taichi,Saito, Atsushi,Kamikawa, Yasunao,et al. AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer[J],2024,22(4):373-385.
APA	Ito, Taichi,Saito, Atsushi,Kamikawa, Yasunao,Nakazawa, Nayuta,&Imaizumi, Kazunori.(2024).AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer.MOLECULAR CANCER RESEARCH,22(4),373-385.
MLA	Ito, Taichi,et al."AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple-Negative Breast Cancer".MOLECULAR CANCER RESEARCH 22.4(2024):373-385.