干旱区生态环境知识资源中心(Arid): The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms

Arid

DOI	10.1111/1751-7915.14430
	The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms
	Van Goethem, Marc W.; Marasco, Ramona; Hong, Pei-Ying; Daffonchio, Daniele
通讯作者	Marasco, R
来源期刊	MICROBIAL BIOTECHNOLOGY
ISSN	1751-7915
出版年	2024
卷号	17 期号:3
英文摘要	In the relentless battle for human health, the proliferation of antibiotic-resistant bacteria has emerged as an impending catastrophe of unprecedented magnitude, potentially driving humanity towards the brink of an unparalleled healthcare crisis. The unyielding advance of antibiotic resistance looms as the foremost threat of the 21st century in clinical, agricultural and environmental arenas. Antibiotic resistance is projected to be the genesis of the next global pandemic, with grim estimations of tens of millions of lives lost annually by 2050. Amidst this impending calamity, our capacity to unearth novel antibiotics has languished, with the past four decades marred by a disheartening 'antibiotic discovery void'. With nearly 80% of our current antibiotics originating from natural or semi-synthetic sources, our responsibility is to cast our investigative nets into uncharted ecological niches teeming with microbial strife, the so-called 'microbial oases of interactions'. Within these oases of interactions, where microorganisms intensively compete for space and nutrients, a dynamic and ever-evolving microbial 'arms race' is constantly in place. Such a continuous cycle of adaptation and counter-adaptation is a fundamental aspect of microbial ecology and evolution, as well as the secrets to unique, undiscovered antibiotics, our last bastion against the relentless tide of resistance. In this context, it is imperative to invest in research to explore the competitive realms, like the plant rhizosphere, biological soil crusts, deep sea hydrothermal vents, marine snow and the most modern plastisphere, in which competitive interactions are at the base of the microorganisms' struggle for survival and dominance in their ecosystems: identify novel antibiotic by targeting microbial oases of interactions could represent a 'missing piece of the puzzle' in our fight against antibiotic resistance. The looming threat of antibiotic-resistant bacteria is one of the major challenges of the 21st century across clinical, agricultural, and environmental domains. Despite this crisis, the antibiotic discovery has stagnated, emphasizing the urgent need to explore yet overlooked ecological niches teeming with microbial competition. For istance, by targeting 'microbial oases of interaction', such as the plant rhizosphere, biological soil crust, deep-sea and the more recent plastisphere, there is potential to uncover novel antibiotics. This approach represents a critical aspect of microbial ecology and evolution, offering a promising avenue in the battle against antibiotic resistance.image
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001181751100001
WOS关键词	COMPETITION ; EVOLUTION ; ECOLOGY ; GENES ; MODEL
WOS类目	Biotechnology & Applied Microbiology ; Microbiology
WOS研究方向	Biotechnology & Applied Microbiology ; Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404904
推荐引用方式 GB/T 7714	Van Goethem, Marc W.,Marasco, Ramona,Hong, Pei-Ying,et al. The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms[J],2024,17(3).
APA	Van Goethem, Marc W.,Marasco, Ramona,Hong, Pei-Ying,&Daffonchio, Daniele.(2024).The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms.MICROBIAL BIOTECHNOLOGY,17(3).
MLA	Van Goethem, Marc W.,et al."The antibiotic crisis: On the search for novel antibiotics and resistance mechanisms".MICROBIAL BIOTECHNOLOGY 17.3(2024).