干旱区生态环境知识资源中心(Arid): Identifying Dementia Severity Among People Living With Dementia Using Administrative Claims Data

Arid

DOI	10.1016/j.jamda.2024.105129
	Identifying Dementia Severity Among People Living With Dementia Using Administrative Claims Data
	Anand, Priyanka; Zhang, Ye; Ngan, Kerry; Mahesri, Mufaddal; Brill, Gregory; Kim, Dae H.; Lin, Kueiyiu Joshua
通讯作者	Lin, KJ
来源期刊	JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
ISSN	1525-8610
EISSN	1538-9375
出版年	2024
卷号	25 期号:9
英文摘要	Objectives: There is currently no reliable tool for classifying dementia severity level based on administrative claims data. We aimed to develop a claims-based model to identify patients with severe dementia among a cohort of patients with dementia. Design: Retrospective cohort study. Setting and Participants: We identified people living with dementia (PLWD) in US Medicare claims data linked with the Minimum Data Set (MDS) and Outcome and Assessment Information Set (OASIS). Methods: Severe dementia was defined based on cognitive and functional status data available in the MDS and OASIS. The dataset was randomly divided into training (70%) and validation (30%) sets, and a logistic regression model was developed to predict severe dementia using baseline (assessed in the prior year) features selected by generalized linear mixed models (GLMMs) with least absolute shrinkage and selection operator (LASSO) regression. We assessed model performance by area under the receiver operating characteristic curve (AUROC), area under precision-recall curve (AUPRC), and precision and recall at various cutoff points, including Youden Index. We compared the model performance with and without using Synthetic Minority Oversampling Technique (SMOTE) to reduce the imbalance of the dataset. Results: Our study cohort included 254,410 PLWD with 17,907 (7.0%) classified as having severe dementia. The AUROC of our primary model, without SMOTE, was 0.81 in the training and 0.80 in the validation set. In the validation set at the optimized Youden Index, the model had a sensitivity of 0.77 and specificity of 0.70. Using a SMOTE-balanced validation set, the model had an AUROC of 0.83, AUPRC of 0.80, sensitivity of 0.79, specificity of 0.74, positive predictive value of 0.75, and negative predictive value of 0.78 when at the optimized Youden Index. Conclusions and Implications: Our claims-based algorithm to identify patients living with severe dementia can be useful for claims-based pharmacoepidemiologic and health services research. (c) 2024 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
英文关键词	Dementia effectiveness severe dementia prediction model safety
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001288603400001
WOS关键词	ATRIAL-FIBRILLATION ; ANTICOAGULATION TREATMENT ; ALZHEIMERS-DISEASE ; HALLUCINATIONS ; MEMANTINE ; WARFARIN ; VALIDITY
WOS类目	Geriatrics & Gerontology
WOS研究方向	Geriatrics & Gerontology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404720
推荐引用方式 GB/T 7714	Anand, Priyanka,Zhang, Ye,Ngan, Kerry,et al. Identifying Dementia Severity Among People Living With Dementia Using Administrative Claims Data[J],2024,25(9).
APA	Anand, Priyanka.,Zhang, Ye.,Ngan, Kerry.,Mahesri, Mufaddal.,Brill, Gregory.,...&Lin, Kueiyiu Joshua.(2024).Identifying Dementia Severity Among People Living With Dementia Using Administrative Claims Data.JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION,25(9).
MLA	Anand, Priyanka,et al."Identifying Dementia Severity Among People Living With Dementia Using Administrative Claims Data".JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION 25.9(2024).