干旱区生态环境知识资源中心(Arid): Surface multi-walled carbon nanotube modified quaternary amine-functionalized polymers for purification and determination of glyphosate and its four metabolites in plasma samples

Arid

DOI	10.1016/j.chroma.2023.464581
	Surface multi-walled carbon nanotube modified quaternary amine-functionalized polymers for purification and determination of glyphosate and its four metabolites in plasma samples
	Pan, Shengdong; Ye, Meijun; Yan, Peng; Guo, Yanbo; Zhang, Dandan; He, Qian
通讯作者	Pan, SD
来源期刊	JOURNAL OF CHROMATOGRAPHY A
ISSN	0021-9673
EISSN	1873-3778
出版年	2024
卷号	1715
英文摘要	The present study focused on the pretreatment and detection of GLY and its four metabolites AMPA, N-acetyl AMPA, N-methyl GLY and N-acetyl GLY in plasma samples. Multi-walled carbon nanotube-modified quaternary amine-functionalized polymers (QA-PDNV@MWCNTs) were synthesized in a controlled manner by selfassembly, and its morphology and composition were extensively characterized. The QA-PDNV@MWCNTs microspheres were then used as an SPE adsorbent for the preparation and rapid determination of GLY and its four metabolites in plasma samples combined with ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). The SPE conditions based on QA-PDNV@MWCNTs were optimized for GLY and its metabolites to obtain the best purification efficiency. The experimental results show that when the adsorbent contains 8% MWCNTs, it can balance the adsorption of target analytes and the purification performance of the adsorbent for impurities. In addition, this study compared the QA-PDNV@MWCNTs based SPE method with the commercial Waters Oasis MAX SPE cartridge and the results showed that the developed method in this study has better resistance to matrix interference. Under optimal conditions, the recoveries of GLY and its metabolites spiked in plasma were 82.6-99.4 % with relative standard deviations (RSDs) of 1.0-7.8 %. The limits of detection (LODs, S/N >= 3) and limits of quantification (LOQs, S/N >= 9) of the method were 0.05-0.33 mu g/L and 0.15-1.00 mu g/L, respectively. Finally, the developed QA-PDNV@MWCNTs based SPE-UPLC-HRMS method was used to confirm GLY poisoning not only on the basis of the detection of the GLY prototype, but also on the basis of its four metabolites.
英文关键词	Solid-phase extraction UPLC-HRMS Trace analysis Poisoning confirmation
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001143926100001
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; AMINOMETHYLPHOSPHONIC ACID ; HERBICIDE GLYPHOSATE ; URINE ; EXTRACTION ; DERIVATIZATION ; SPECTROMETRY ; GLUFOSINATE ; WATER
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404403
推荐引用方式 GB/T 7714	Pan, Shengdong,Ye, Meijun,Yan, Peng,et al. Surface multi-walled carbon nanotube modified quaternary amine-functionalized polymers for purification and determination of glyphosate and its four metabolites in plasma samples[J],2024,1715.
APA	Pan, Shengdong,Ye, Meijun,Yan, Peng,Guo, Yanbo,Zhang, Dandan,&He, Qian.(2024).Surface multi-walled carbon nanotube modified quaternary amine-functionalized polymers for purification and determination of glyphosate and its four metabolites in plasma samples.JOURNAL OF CHROMATOGRAPHY A,1715.
MLA	Pan, Shengdong,et al."Surface multi-walled carbon nanotube modified quaternary amine-functionalized polymers for purification and determination of glyphosate and its four metabolites in plasma samples".JOURNAL OF CHROMATOGRAPHY A 1715(2024).