干旱区生态环境知识资源中心(Arid): G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.

Arid

DOI	10.1093/jb/mvae027
	G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.
	Kanemoto, Soshi
通讯作者	Kanemoto, S
来源期刊	JOURNAL OF BIOCHEMISTRY
ISSN	0021-924X
EISSN	1756-2651
出版年	2024
卷号	176 期号:1 页码:55-68
英文摘要	G protein-coupled receptor 84 (Gpr84) is reportedly activated by medium-chain fatty acids and is involved in the pathology of liver fibrosis. Inflammatory stimulants, such as lipopolysaccharide and tumor necrosis factor-alpha, upregulate Gpr84 expression. However, the detailed molecular mechanism by which Gpr84 is induced remains unknown. Inflammatory stimulation also evokes endoplasmic reticulum (ER) stress, but there has been no direct evidence to link Gpr84 expression and the ER stress response. Administration of tunicamycin (Tm) provokes ER stress and acute steatosis in the liver tissue of mice. Here, in situ hybridization analysis revealed that induction of Gpr84 expression occurred in parenchymal cells in the liver tissue following Tm administration. Gene expression analysis using a reporter assay showed that the intron 1 region of Gpr84 was involved in induction of the gene under ER stress conditions. Furthermore, Tm-dependent upregulation of Gpr84 was blocked by the small chemical compound AEBSF, an inhibitor of ER stress transducers, in vitro and in vivo. In conclusion, the current study marks the discovery that the ER stress agent Tm induces the expression of Gpr84. Graphical Abstract
英文关键词	Creb3 family endoplasmic reticulum stress G protein-coupled receptor 84 liver tunicamycin
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001196604100001
WOS关键词	ENDOPLASMIC-RETICULUM STRESS ; TRANSCRIPTION FACTOR ; TRANSDUCER OASIS ; CREB/ATF-FAMILY ; MESSENGER-RNA ; AXON GROWTH ; GPR84 EX33 ; IDENTIFICATION ; LUMAN/CREB3 ; INDUCTION
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404392
推荐引用方式 GB/T 7714	Kanemoto, Soshi. G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.[J],2024,176(1):55-68.
APA	Kanemoto, Soshi.(2024).G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver..JOURNAL OF BIOCHEMISTRY,176(1),55-68.
MLA	Kanemoto, Soshi."G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.".JOURNAL OF BIOCHEMISTRY 176.1(2024):55-68.

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