干旱区生态环境知识资源中心(Arid): The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions

Arid

DOI	10.7150/ijms.90189
	The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions
	Zhao, Ying; Yu, Zhou; Song, Yajuan; Fan, Liumeizi; Lei, Ting; He, Yinbin; Hu, Sheng
通讯作者	Hu, S
来源期刊	INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
ISSN	1449-1907
出版年	2024
卷号	21 期号:1 页码:123-136
英文摘要	CREB3 subfamily belongs to the bZIP transcription factor family and comprises five members. Normally they are located on the endoplasmic reticulum (ER) membranes and proteolytically activated through RIP (regulated intramembrane proteolysis) on Golgi apparatus to liberate the N-terminus to serve as transcription factors. CREB3L1 acting as one of them transcriptionally regulates the expressions of target genes and exhibits distinct functions from the other members of CREB3 family in eukaryotes. Physiologically, CREB3L1 involves in the regulation of bone morphogenesis, neurogenesis, neuroendocrine, secretory cell differentiation, and angiogenesis. Pathologically, CREB3L1 implicates in the modulation of osteogenesis imperfecta, low grade fibro myxoid sarcoma (LGFMS), sclerosing epithelioid fibrosarcoma (SEF), glioma, breast cancer, thyroid cancer, and tissue fibrosis. This review summarizes the upstream and downstream regulatory network of CREB3L1 and thoroughly presents our current understanding of CREB3L1 research progress in both physiological and pathological conditions with special focus on the novel findings of CREB3L1 in cancers.
英文关键词	Bone Morphogenesis Neurogenesis Endocrine Angiogenesis Tumorigenesis Fibrosis
类型	Review
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001106899900012
WOS关键词	SCLEROSING EPITHELIOID FIBROSARCOMA ; GRADE FIBROMYXOID SARCOMA ; TRANSCRIPTION FACTOR OASIS ; STRESS TRANSDUCER OASIS ; CORE PROTEIN GENES ; CREB/ATF-FAMILY ; OSTEOGENESIS IMPERFECTA ; EXPRESSION ; ELEMENT ; PATHWAY
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404254
推荐引用方式 GB/T 7714	Zhao, Ying,Yu, Zhou,Song, Yajuan,et al. The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions[J],2024,21(1):123-136.
APA	Zhao, Ying.,Yu, Zhou.,Song, Yajuan.,Fan, Liumeizi.,Lei, Ting.,...&Hu, Sheng.(2024).The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions.INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,21(1),123-136.
MLA	Zhao, Ying,et al."The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions".INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 21.1(2024):123-136.