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DOI | 10.7150/ijms.90189 |
The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions | |
Zhao, Ying; Yu, Zhou; Song, Yajuan; Fan, Liumeizi; Lei, Ting; He, Yinbin; Hu, Sheng | |
通讯作者 | Hu, S |
来源期刊 | INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
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ISSN | 1449-1907 |
出版年 | 2024 |
卷号 | 21期号:1页码:123-136 |
英文摘要 | CREB3 subfamily belongs to the bZIP transcription factor family and comprises five members. Normally they are located on the endoplasmic reticulum (ER) membranes and proteolytically activated through RIP (regulated intramembrane proteolysis) on Golgi apparatus to liberate the N-terminus to serve as transcription factors. CREB3L1 acting as one of them transcriptionally regulates the expressions of target genes and exhibits distinct functions from the other members of CREB3 family in eukaryotes. Physiologically, CREB3L1 involves in the regulation of bone morphogenesis, neurogenesis, neuroendocrine, secretory cell differentiation, and angiogenesis. Pathologically, CREB3L1 implicates in the modulation of osteogenesis imperfecta, low grade fibro myxoid sarcoma (LGFMS), sclerosing epithelioid fibrosarcoma (SEF), glioma, breast cancer, thyroid cancer, and tissue fibrosis. This review summarizes the upstream and downstream regulatory network of CREB3L1 and thoroughly presents our current understanding of CREB3L1 research progress in both physiological and pathological conditions with special focus on the novel findings of CREB3L1 in cancers. |
英文关键词 | Bone Morphogenesis Neurogenesis Endocrine Angiogenesis Tumorigenesis Fibrosis |
类型 | Review |
语种 | 英语 |
开放获取类型 | Green Published, gold |
收录类别 | SCI-E |
WOS记录号 | WOS:001106899900012 |
WOS关键词 | SCLEROSING EPITHELIOID FIBROSARCOMA ; GRADE FIBROMYXOID SARCOMA ; TRANSCRIPTION FACTOR OASIS ; STRESS TRANSDUCER OASIS ; CORE PROTEIN GENES ; CREB/ATF-FAMILY ; OSTEOGENESIS IMPERFECTA ; EXPRESSION ; ELEMENT ; PATHWAY |
WOS类目 | Medicine, General & Internal |
WOS研究方向 | General & Internal Medicine |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/404254 |
推荐引用方式 GB/T 7714 | Zhao, Ying,Yu, Zhou,Song, Yajuan,et al. The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions[J],2024,21(1):123-136. |
APA | Zhao, Ying.,Yu, Zhou.,Song, Yajuan.,Fan, Liumeizi.,Lei, Ting.,...&Hu, Sheng.(2024).The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions.INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,21(1),123-136. |
MLA | Zhao, Ying,et al."The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions".INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 21.1(2024):123-136. |
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