Arid
DOI10.7150/ijms.90189
The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions
Zhao, Ying; Yu, Zhou; Song, Yajuan; Fan, Liumeizi; Lei, Ting; He, Yinbin; Hu, Sheng
通讯作者Hu, S
来源期刊INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
ISSN1449-1907
出版年2024
卷号21期号:1页码:123-136
英文摘要CREB3 subfamily belongs to the bZIP transcription factor family and comprises five members. Normally they are located on the endoplasmic reticulum (ER) membranes and proteolytically activated through RIP (regulated intramembrane proteolysis) on Golgi apparatus to liberate the N-terminus to serve as transcription factors. CREB3L1 acting as one of them transcriptionally regulates the expressions of target genes and exhibits distinct functions from the other members of CREB3 family in eukaryotes. Physiologically, CREB3L1 involves in the regulation of bone morphogenesis, neurogenesis, neuroendocrine, secretory cell differentiation, and angiogenesis. Pathologically, CREB3L1 implicates in the modulation of osteogenesis imperfecta, low grade fibro myxoid sarcoma (LGFMS), sclerosing epithelioid fibrosarcoma (SEF), glioma, breast cancer, thyroid cancer, and tissue fibrosis. This review summarizes the upstream and downstream regulatory network of CREB3L1 and thoroughly presents our current understanding of CREB3L1 research progress in both physiological and pathological conditions with special focus on the novel findings of CREB3L1 in cancers.
英文关键词Bone Morphogenesis Neurogenesis Endocrine Angiogenesis Tumorigenesis Fibrosis
类型Review
语种英语
开放获取类型Green Published, gold
收录类别SCI-E
WOS记录号WOS:001106899900012
WOS关键词SCLEROSING EPITHELIOID FIBROSARCOMA ; GRADE FIBROMYXOID SARCOMA ; TRANSCRIPTION FACTOR OASIS ; STRESS TRANSDUCER OASIS ; CORE PROTEIN GENES ; CREB/ATF-FAMILY ; OSTEOGENESIS IMPERFECTA ; EXPRESSION ; ELEMENT ; PATHWAY
WOS类目Medicine, General & Internal
WOS研究方向General & Internal Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/404254
推荐引用方式
GB/T 7714
Zhao, Ying,Yu, Zhou,Song, Yajuan,et al. The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions[J],2024,21(1):123-136.
APA Zhao, Ying.,Yu, Zhou.,Song, Yajuan.,Fan, Liumeizi.,Lei, Ting.,...&Hu, Sheng.(2024).The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions.INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,21(1),123-136.
MLA Zhao, Ying,et al."The Regulatory Network of CREB3L1 and Its Roles in Physiological and Pathological Conditions".INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 21.1(2024):123-136.
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