干旱区生态环境知识资源中心(Arid): Serologic evidence of human exposure to the severe fever with thrombocytopenia syndrome virus and associated viruses in Kenya

Arid

DOI	10.1080/23744235.2024.2370965
	Serologic evidence of human exposure to the severe fever with thrombocytopenia syndrome virus and associated viruses in Kenya
	Zohaib, Ali; Zhang, Jingyuan; Agwanda, Bernard; Chen, Jing; Luo, Yun; Hu, Ben; Masika, Moses; Lichoti, Jacqueline Kasiiti; Waruhiu, Cecilia Njeri; Obanda, Vincent; Deng, Fei; Shi, Zhengli; Ommeh, Sheila; Shen, Shu
通讯作者	Shen, S
来源期刊	INFECTIOUS DISEASES
ISSN	2374-4235
EISSN	2374-4243
出版年	2024
卷号	56 期号:9 页码:776-782
英文摘要	BackgroundAlthough the diverse communities of tick-borne viruses (TBVs) have recently been proposed, the threat of infection and exposure to TBVs among humans across Kenya has been poorly understood.ObjectiveSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne viral agent associated with the epidemic of severe fever with thrombocytopenia syndrome (SFTS) disease in East Asian countries. This study investigated the seroprevalence of SFTSV among humans in Kenya.MethodsSerum samples were collected from 459 healthy people in Kenya and tested for anti-SFTSV antibodies, which were further confirmed by immunofluorescence assays. Micro neutralization assays were performed to identify neutralising antibodies against SFTSV and SFTSV-related viruses.ResultsA high seroprevalence (162/459, 35.3%) of SFTSV was found in the samples from nine of the ten surveyed counties in Kenya, with higher rates in the eastern plateau forelands, semiarid and arid areas, and coastal areas than in the area aside Rift valley. The seropositive rate was slightly higher in women than in men and was significantly higher in the 55-64 age group. Neutralising activity against SFTSV was detected in four samples, resulting in a rate of 0.9%. No cross-neutralising activity against the SFTSV-related Guertu virus and Heartland virus was detected in the anti-SFTSV positive serum samples.ConclusionThe results provide serologic evidence of human exposure to SFTSV in Kenya and extend our understanding of SFTSV prevalence from Asia to Africa. The findings suggest an increasing threat of exposure to emerging TBVs and the need to investigate tick viromes in Kenya.
英文关键词	Severe fever with thrombocytopenia syndrome virus seroprevalence serologic exposure SFTSV-related virus Kenya
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:001261767900001
WOS关键词	PHLEBOVIRUS ; LIVESTOCK
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404178
推荐引用方式 GB/T 7714	Zohaib, Ali,Zhang, Jingyuan,Agwanda, Bernard,et al. Serologic evidence of human exposure to the severe fever with thrombocytopenia syndrome virus and associated viruses in Kenya[J],2024,56(9):776-782.
APA	Zohaib, Ali.,Zhang, Jingyuan.,Agwanda, Bernard.,Chen, Jing.,Luo, Yun.,...&Shen, Shu.(2024).Serologic evidence of human exposure to the severe fever with thrombocytopenia syndrome virus and associated viruses in Kenya.INFECTIOUS DISEASES,56(9),776-782.
MLA	Zohaib, Ali,et al."Serologic evidence of human exposure to the severe fever with thrombocytopenia syndrome virus and associated viruses in Kenya".INFECTIOUS DISEASES 56.9(2024):776-782.