干旱区生态环境知识资源中心(Arid): Modulations in antioxidant defence system and expression of genes involved in antioxidant and apoptosis pathway helps ward-off heat stress in cows reared in hot-arid ambience of Thar desert

Arid

DOI	10.56093/ijans.v94i4.132953
	Modulations in antioxidant defence system and expression of genes involved in antioxidant and apoptosis pathway helps ward-off heat stress in cows reared in hot-arid ambience of Thar desert
	Gujar, Gayatri; Kumar, Vijay; Sodhi, Monika; Vivek, Prince; Tiwari, Manish; Mukesh, Manishi
通讯作者	Mukesh, M
来源期刊	INDIAN JOURNAL OF ANIMAL SCIENCES
ISSN	0367-8318
出版年	2024
卷号	94 期号:4 页码:333-341
英文摘要	The present study was designed to assess the seasonal perturbations in key antioxidant parameters: ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging activity, lipid per oxidation (LPO), uric acid and reduced glutathione (GSH) assay along with expression profile of genes that regulate the antioxidant pathway: manganese superoxide dismutase (SOD2), Glutathione Peroxidase 1 (GPX1) and apoptosis pathway: B -cell lymphoma 2 (BCL2) and Bcl-2-associated X protein (BAX) in the two crucial indicine cattle breedsSahiwal and Kankrej. The study was carried out in the hot -arid region of Rajasthan across four seasons, wherein, the meteorological parameters were recorded across seasons to calculate the prevailing temperature -humidity index (THI) to assess the extent of heat load on cows. The study revealed huge diurnal variations in the temperature across four seasons, while the THI during summer and hot -humid seasons was well in excess of 80, highlighting significant heat stress on cows. All the key antioxidant parameters, except GSH registered an increase with the incremental THI. The transcriptional profile of SOD2 and GPX1 mRNA expression revealed significantly higher expression during the higher THI months of both summer and hot -humid seasons. The expression pattern of BAX and BCL2 mRNA in PBMCs of Sahiwal cows revealed an initial induction during the month of summer season with significantly higher expression, followed by a decline by the hot -humid season. The findings highlight a crucial role played by antioxidant defence and genes regulating apoptosis pathway in thermotolerance of indicine cattle breeds.
英文关键词	Antioxidants Apoptosis Bos indicus Gene expression Seasonal study Temperature humidity index Thermotolerance
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001198704300010
WOS关键词	SEASONAL-CHANGES ; THERMAL-STRESS ; SHOCK-PROTEIN ; WHOLE-BLOOD ; BCL-2 ; DAIRY ; CATTLE ; GLUTATHIONE ; FAMILY ; TEMPERATURE
WOS类目	Agriculture, Dairy & Animal Science
WOS研究方向	Agriculture
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/404162
推荐引用方式 GB/T 7714	Gujar, Gayatri,Kumar, Vijay,Sodhi, Monika,et al. Modulations in antioxidant defence system and expression of genes involved in antioxidant and apoptosis pathway helps ward-off heat stress in cows reared in hot-arid ambience of Thar desert[J],2024,94(4):333-341.
APA	Gujar, Gayatri,Kumar, Vijay,Sodhi, Monika,Vivek, Prince,Tiwari, Manish,&Mukesh, Manishi.(2024).Modulations in antioxidant defence system and expression of genes involved in antioxidant and apoptosis pathway helps ward-off heat stress in cows reared in hot-arid ambience of Thar desert.INDIAN JOURNAL OF ANIMAL SCIENCES,94(4),333-341.
MLA	Gujar, Gayatri,et al."Modulations in antioxidant defence system and expression of genes involved in antioxidant and apoptosis pathway helps ward-off heat stress in cows reared in hot-arid ambience of Thar desert".INDIAN JOURNAL OF ANIMAL SCIENCES 94.4(2024):333-341.