干旱区生态环境知识资源中心(Arid): Antioxidant analysis, induced toxicology, spectroscopy and HPLC, GC-MS characterization of Argyrolobium arabicum (Decne.) Jaub. & Spach

Arid

DOI	10.1007/s10722-024-02049-5
	Antioxidant analysis, induced toxicology, spectroscopy and HPLC, GC-MS characterization of Argyrolobium arabicum (Decne.) Jaub. & Spach
	Makhkamov, Trobjon; Zafar, Sadia; Al Farraj, Dunia A.; Elshikh, Mohamed S.; Yuldashev, Akramjon; Islamov, Sokhib; Yunusov, Salohiddinjon; Naraliyeva, Nasibakhon; Kakhramonovich, Otahonov Kobuljon; Khabibullaev, Jamshidbek; Imomova, Mukammal; Babir, Baysunov; Huseynov, Elchin; Kiren, Ifrah
通讯作者	Kiren, I
来源期刊	GENETIC RESOURCES AND CROP EVOLUTION
ISSN	0925-9864
EISSN	1573-5109
出版年	2024
英文摘要	The inherent natural antioxidants found in numerous medicinal plants (MPs) play a crucial role in counteracting the detrimental impacts of oxidative stress. MPs contains polyphenols and flavonoids, which serve as scavengers for free radicals, mitigating oxidative stress and offering potential as alternative treatments for a range of human ailments. The significance of this study lies in its chromatographic spectrum identification, providing a in-depth exploration of the antioxidant capacities and toxicological profiles within the genetic resources of Argyrolobium arabicum. This study described the chromatographic, spectroscopic, antioxidant and hepatoprotective actions of A. arabicum leaves collected from arid zones of Saudi Arabia. Argyrolobium arabicum chromatographic separations of bioactive compounds (HPLC detection isolate prominent compounds D-Pinitol and vitexin) and GC-MS spectra identified five phenolics and six flavonoids organic compounds. FT-IR spectroscopy revealed prominent functional group of alcohols and carboxylic acids bonds stretching. The hepatic toxicity and protective effects were notably administrated of A. arabicum extracts at a dosage of 300 mg/kg, leading to the restoration of ALT levels to 51 (U/L), AST levels to 71.6 (U/L), ALP levels to 169 U/L, and total bilirubin levels to 0.58 (g/dL), which had been altered by the negative control. This research basically contributing to the understanding of medicinally important A. arabicum potential applications in pharmaceutical and environmental fields and used as to elucidate the complex genomic mechanisms explaining the bioactivity and safety of medicinal species.
英文关键词	Bioactive metabolites Chromatography Medicinal plants Spectrosocpy Toxicology
类型	Article ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001244793800001
WOS关键词	MEDICINE ; EXTRACT
WOS类目	Agronomy ; Plant Sciences
WOS研究方向	Agriculture ; Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403916
推荐引用方式 GB/T 7714	Makhkamov, Trobjon,Zafar, Sadia,Al Farraj, Dunia A.,et al. Antioxidant analysis, induced toxicology, spectroscopy and HPLC, GC-MS characterization of Argyrolobium arabicum (Decne.) Jaub. & Spach[J],2024.
APA	Makhkamov, Trobjon.,Zafar, Sadia.,Al Farraj, Dunia A..,Elshikh, Mohamed S..,Yuldashev, Akramjon.,...&Kiren, Ifrah.(2024).Antioxidant analysis, induced toxicology, spectroscopy and HPLC, GC-MS characterization of Argyrolobium arabicum (Decne.) Jaub. & Spach.GENETIC RESOURCES AND CROP EVOLUTION.
MLA	Makhkamov, Trobjon,et al."Antioxidant analysis, induced toxicology, spectroscopy and HPLC, GC-MS characterization of Argyrolobium arabicum (Decne.) Jaub. & Spach".GENETIC RESOURCES AND CROP EVOLUTION (2024).