干旱区生态环境知识资源中心(Arid): Development and validation of the Axiom-MaruPri SNP chip for genetic analyses of domesticated old world camelids

Arid

DOI	10.1016/j.gene.2024.148541
	Development and validation of the Axiom-MaruPri SNP chip for genetic analyses of domesticated old world camelids
	Vijh, Ramesh Kumar; Sharma, Upasna; Arora, Reena; Kapoor, Prerna; Raheja, Meenal; Sharma, Rekha; Ahlawat, Sonika; Dureja, Vandana
通讯作者	Arora, R
来源期刊	GENE
ISSN	0378-1119
EISSN	1879-0038
出版年	2024
卷号	921
英文摘要	Camels play a crucial socio-economic role in sustaining the livelihoods of millions in arid and semi-arid regions. They possess remarkable physiological attributes which enable them to thrive in extreme environments, and provide a source of meat, milk and transportation. With their unique traits, camels embody an irreplaceable source of untapped genomic knowledge. This study introduces Axiom-MaruPri, a medium-density SNP chip meticulously designed and validated for both Camelus bactrianus and Camelus dromedarius. Comprising of 182,122 SNP markers, derived from the re-sequenced data of nine Indian dromedary breeds and the doublehumped Bactrian camel, this SNP chip offers 34,894 markers that display polymorphism in both species. It achieves an estimated inter-marker distance of 14 Kb, significantly enhancing the coverage of the camel genome. The medium-density chip has been successfully genotyped using 480 camel samples, achieving an impressive 99 % call rate, with 96 % of the 182,122 SNPs being highly reliable for genotyping. Phylogenetic analysis and Discriminant Analysis of Principal Components yield clear distinctions between Bactrian camels and dromedaries. Moreover, the discriminant functions substantially enhance the classification of dromedary camels into different breeds. The clustering of various camel breeds reveals an apparent correlation between geographical and genetic distances. The results affirm the efficacy of this SNP array, demonstrating high genotyping precision and clear differentiation between Bactrian and dromedary camels. With an enhanced genome coverage, accuracy and economic efficiency the Axiom_MaruPri SNP chip is poised to advance genomic breeding research in camels. It holds the potential to serve as an invaluable genetic resource for investigating population structure, genomewide association studies and implementing genomic selection in domesticated camelid species.
英文关键词	Bactrian Camel Dromedary DAPC Phylogeny SNP array
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001265805100001
WOS关键词	ASSOCIATION ; DIVERSITY
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403909
推荐引用方式 GB/T 7714	Vijh, Ramesh Kumar,Sharma, Upasna,Arora, Reena,et al. Development and validation of the Axiom-MaruPri SNP chip for genetic analyses of domesticated old world camelids[J],2024,921.
APA	Vijh, Ramesh Kumar.,Sharma, Upasna.,Arora, Reena.,Kapoor, Prerna.,Raheja, Meenal.,...&Dureja, Vandana.(2024).Development and validation of the Axiom-MaruPri SNP chip for genetic analyses of domesticated old world camelids.GENE,921.
MLA	Vijh, Ramesh Kumar,et al."Development and validation of the Axiom-MaruPri SNP chip for genetic analyses of domesticated old world camelids".GENE 921(2024).