干旱区生态环境知识资源中心(Arid): Current and emerging pharmacotherapy for the treatment of gastroparesis

Arid

DOI	10.1080/14656566.2024.2344646
	Current and emerging pharmacotherapy for the treatment of gastroparesis
	Kalas, M. Ammar; Sarosiek, Irene; McCallum, Richard W.
通讯作者	McCallum, RW
来源期刊	EXPERT OPINION ON PHARMACOTHERAPY
ISSN	1465-6566
EISSN	1744-7666
出版年	2024
卷号	25 期号:5 页码:541-549
英文摘要	IntroductionGastroparesis is a chronic disorder characterized by decreased gastric emptying and presents with nausea, vomiting, and abdominal pain which impacts patients' quality of life greatly. The treatment modalities available for gastroparesis have been expanding over the past 2 decades. Currently, there are multiple options available for gastroparesis, albeit with only one FDA-approved medication until June 2021.Areas coveredWe review the different treatments available for gastroparesis and discuss the recently FDA-approved intranasal formulation of metoclopramide. This nasal spray guarantees metoclopramide absorption within 15 min of application bypassing first pass metabolism in the liver and overcoming the limitations of the oral formulation not passing into the small intestine for absorption because of a gastroparetic stomach or a patient unable to take the oral metoclopramide because of nausea and vomiting.Expert opinionWe now find ourselves in an oasis after spending many years in a 'desert' regarding pharmacologic therapies available for gastroparesis. The expansion of the research involving dopamine receptor antagonists and delving into alternative mechanisms of alleviating gastroparesis symptoms has been crucial in the landscape of gastroparesis. This is especially true as our knowledge of gastroparesis has proven that simply improving gastric emptying does not necessarily translate to clinical improvement.
英文关键词	Gastroparesis metoclopramide dopamine receptor antagonists 5HT4 agonists novel pharmacotherapy
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001215382900001
WOS关键词	CARDIOVASCULAR SAFETY PROFILE ; DIABETIC GASTROPARESIS ; DOMPERIDONE THERAPY ; METOCLOPRAMIDE ; SYMPTOMS ; ERYTHROMYCIN ; EFFICACY ; MANAGEMENT ; RECEPTOR ; OUTCOMES
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403711
推荐引用方式 GB/T 7714	Kalas, M. Ammar,Sarosiek, Irene,McCallum, Richard W.. Current and emerging pharmacotherapy for the treatment of gastroparesis[J],2024,25(5):541-549.
APA	Kalas, M. Ammar,Sarosiek, Irene,&McCallum, Richard W..(2024).Current and emerging pharmacotherapy for the treatment of gastroparesis.EXPERT OPINION ON PHARMACOTHERAPY,25(5),541-549.
MLA	Kalas, M. Ammar,et al."Current and emerging pharmacotherapy for the treatment of gastroparesis".EXPERT OPINION ON PHARMACOTHERAPY 25.5(2024):541-549.