干旱区生态环境知识资源中心(Arid): Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis

Arid

DOI	10.1002/dta.3659
	Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis
	Davies, Bethan; Paul, Richard; Osselton, David; Evers, Richard; Woolley, Timothy
通讯作者	Davies, B
来源期刊	DRUG TESTING AND ANALYSIS
ISSN	1942-7603
EISSN	1942-7611
出版年	2024
英文摘要	New psychoactive substances are produced and marketed to mimic the effects of their illicit counterparts and to attempt to evade drug tests and prosecution. Here, we present the optimisation, validation and application of an analytical method using liquid chromatography-time-of-flight mass spectrometry to detect and quantify 37 new psychoactive substances and illicit substances in wastewater from South Wales, UK, using a targeted analysis method. Sample preparation was performed using solid-phase extraction with Oasis HLB cartridges. The LC separation was performed using a YMC-Triart Phenyl 450 bar column (12 nm, 5 mu m, 100 x 3 mm) which provided good separation and resolution for all targeted analytes with a run time of 9 min. The method was validated using the following parameters: sensitivity, selectivity, linearity, accuracy, precision, recovery and matrix effects. The method was then applied to influent wastewater samples collected from two wastewater treatment plants in Wales, UK.
英文关键词	illicit drugs LC-ToF-MS new psychoactive substances solid-phase extraction wastewater
类型	Article ; Early Access
语种	英语
开放获取类型	Green Accepted, hybrid
收录类别	SCI-E
WOS记录号	WOS:001162788500001
WOS关键词	SOLID-PHASE EXTRACTION ; PERSONAL CARE PRODUCTS ; SURFACE-WATER ; ILLICIT DRUGS ; ENDOCRINE DISRUPTORS ; MASS-SPECTROMETRY ; PHARMACEUTICALS ; ELECTROSPRAY ; METABOLITES ; URINE
WOS类目	Biochemical Research Methods ; Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403305
推荐引用方式 GB/T 7714	Davies, Bethan,Paul, Richard,Osselton, David,et al. Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis[J],2024.
APA	Davies, Bethan,Paul, Richard,Osselton, David,Evers, Richard,&Woolley, Timothy.(2024).Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis.DRUG TESTING AND ANALYSIS.
MLA	Davies, Bethan,et al."Absence of new psychoactive substances in wastewater from South Wales, UK, revealed by optimised liquid chromatography-time-of-flight analysis".DRUG TESTING AND ANALYSIS (2024).