干旱区生态环境知识资源中心(Arid): Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)

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	Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)
	Saito, Koichi; Yokota, Mai; Ito, Rie; Sakamoto, Miho; Higashiyama, Kimio
通讯作者	Saito, K
来源期刊	CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN	0009-2363
出版年	2024
卷号	72 期号:1 页码:11-15
英文摘要	This study investigates the stability of nitrazepam (NZP), a benzodiazepine drug, under basic conditions, since alkaline putrefactive amines and ammonia are produced once bodies are left to decompose for a long period postmortem after a murder involving NZP or an accidental overdose of NZP. The degradation of NZP in an aqueous alkaline solution was investigated by LC/photodiode array detector (PDA) where the NZP degradation product was isolated and purified by solid -phase extraction using Oasis (R) MCX, and its chemical structure was determined by LC/time-of-flight (TOF)-MS, NMR spectroscopy, and single -crystal X-ray crystallography. The results revealed that NZP was immediately degraded under basic conditions with 2-amino-5-nitrobenzophenone being an intermediate which further degraded to provide 2-hydroxy-5-nitrobenzophenone as the final degradation product. These results are expected to be useful in clinical chemistry and forensic science, such as the detection of drugs during postmortem examination and suspected addiction.
英文关键词	benzodiazepine nitrazepam alkaline hydrolysis degradation pathway
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:001178330700002
WOS关键词	ARTIFICIAL GASTRIC-JUICE ; STABILITY
WOS类目	Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403179
推荐引用方式 GB/T 7714	Saito, Koichi,Yokota, Mai,Ito, Rie,et al. Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)[J],2024,72(1):11-15.
APA	Saito, Koichi,Yokota, Mai,Ito, Rie,Sakamoto, Miho,&Higashiyama, Kimio.(2024).Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV).CHEMICAL & PHARMACEUTICAL BULLETIN,72(1),11-15.
MLA	Saito, Koichi,et al."Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)".CHEMICAL & PHARMACEUTICAL BULLETIN 72.1(2024):11-15.