干旱区生态环境知识资源中心(Arid): Physical Health and Transition to Psychosis in People at Clinical High Risk

Arid

DOI	10.3390/biomedicines12030523
	Physical Health and Transition to Psychosis in People at Clinical High Risk
	De Micheli, Andrea; Provenzani, Umberto; Krakowski, Kamil; Oliver, Dominic; Damiani, Stefano; Brondino, Natascia; Mcguire, Philip; Fusar-Poli, Paolo
通讯作者	Fusar-Poli, P
来源期刊	BIOMEDICINES
EISSN	2227-9059
出版年	2024
卷号	12 期号:3
英文摘要	Background: The clinical high risk for psychosis (CHR-P) construct represents an opportunity for prevention and early intervention in young adults, but the relationship between risk for psychosis and physical health in these patients remains unclear. Methods: We conducted a RECORD-compliant clinical register-based cohort study, selecting the long-term cumulative risk of developing a persistent psychotic disorder as the primary outcome. We investigated associations between primary outcome and physical health data with Electronic Health Records at the South London and Maudsley (SLaM) NHS Trust, UK (January 2013-October 2020). We performed survival analyses using Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models. Results: The database included 137 CHR-P subjects; 21 CHR-P developed psychosis during follow-up, and the cumulative incidence of psychosis risk was 4.9% at 1 year and 56.3% at 7 years. Log-rank tests suggested that psychosis risk might change between different levels of nicotine and alcohol dependence. Kaplan-Meier curve analyses indicated that non-hazardous drinkers may have a lower psychosis risk than non-drinkers. In the Cox proportional hazard model, nicotine dependence presented a hazard ratio of 1.34 (95% CI: 1.1-1.64) (p = 0.01), indicating a 34% increase in psychosis risk for every additional point on the Fagerstrom Test for Nicotine Dependence. Conclusions: Our findings suggest that a comprehensive assessment of tobacco and alcohol use, diet, and physical activity in CHR-P subjects is key to understanding how physical health contributes to psychosis risk.
英文关键词	physical health psychosis risk CHR-P
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:001191712800001
WOS关键词	ULTRA-HIGH-RISK ; HEART-RATE-VARIABILITY ; MAJOR DEPRESSIVE DISORDER ; BODY-MASS INDEX ; SOUTH-LONDON OASIS ; SUBSTANCE USE ; YOUNG-PEOPLE ; BIPOLAR DISORDER ; ACTIVITY QUESTIONNAIRE ; GENERAL-POPULATION
WOS类目	Biochemistry & Molecular Biology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Biochemistry & Molecular Biology ; Research & Experimental Medicine ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/403034
推荐引用方式 GB/T 7714	De Micheli, Andrea,Provenzani, Umberto,Krakowski, Kamil,et al. Physical Health and Transition to Psychosis in People at Clinical High Risk[J],2024,12(3).
APA	De Micheli, Andrea.,Provenzani, Umberto.,Krakowski, Kamil.,Oliver, Dominic.,Damiani, Stefano.,...&Fusar-Poli, Paolo.(2024).Physical Health and Transition to Psychosis in People at Clinical High Risk.BIOMEDICINES,12(3).
MLA	De Micheli, Andrea,et al."Physical Health and Transition to Psychosis in People at Clinical High Risk".BIOMEDICINES 12.3(2024).