干旱区生态环境知识资源中心(Arid): Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition

Arid

DOI	10.14336/AD.2022.1210
	Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition
	Wang, Maxwell Bond; Rahmani, Farzaneh; Benzinger, Tammie L. S.; Raji, Cyrus
通讯作者	Raji, C
来源期刊	AGING AND DISEASE
ISSN	2152-5250
出版年	2024
卷号	15 期号:4 页码:1899-1912
英文摘要	Alzheimer disease (AD) and obesity are related to disruptions in the white matter (WM) connectome. We examined the link between the WM connectome and obesity and AD through edge-density imaging/index (EDI), a tractography-based method that characterizes the anatomical embedding of tractography connections. A total of 60 participants, 30 known to convert from normal cognition or mild cognitive impairment to AD within a minimum of 24 months of follow up, were selected from the Alzheimer disease Neuroimaging Initiative (ADNI). Diffusion-weighted MR images from the baseline scans were used to extract fractional anisotropy (FA) and EDI maps that were subsequently averaged using deterministic WM tractography based on the Desikan-Killiany atlas. Multiple linear and logistic regression analysis were used to identify the weighted sum of tract-specific FA or EDI indices that maximized correlation to body-mass-index (BMI) or conversion to AD. Participants from the Open Access Series of Imaging Studies (OASIS) were used as an independent validation for the BMI findings. The edge-density rich, periventricular, commissural and projection fibers were among the most important WM tracts linking BMI to FA as well as to EDI. WM fibers that contributed significantly to the regression model related to BMI overlapped with those that predicted conversion; specifically in the frontopontine, corticostriatal, and optic radiation pathways. These results were replicated by testing the tract-specific coefficients found using ADNI in the OASIS-4 dataset. WM mapping with EDI enables identification of an abnormal connectome implicated in both obesity and conversion to AD.
英文关键词	Edge-Density Imaging Alzheimer disease Neuroimaging Initiative Obesity Structural Connectome
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000928226100001
WOS关键词	ALZHEIMERS-DISEASE ; MRI ; DEMENTIA ; HYPEREXCITABILITY ; MICROSTRUCTURE ; CONNECTIVITY ; CONNECTOME ; MIDLIFE ; SYSTEM ; RISK
WOS类目	Geriatrics & Gerontology
WOS研究方向	Geriatrics & Gerontology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/402624
推荐引用方式 GB/T 7714	Wang, Maxwell Bond,Rahmani, Farzaneh,Benzinger, Tammie L. S.,et al. Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition[J],2024,15(4):1899-1912.
APA	Wang, Maxwell Bond,Rahmani, Farzaneh,Benzinger, Tammie L. S.,&Raji, Cyrus.(2024).Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition.AGING AND DISEASE,15(4),1899-1912.
MLA	Wang, Maxwell Bond,et al."Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition".AGING AND DISEASE 15.4(2024):1899-1912.