干旱区生态环境知识资源中心(Arid): Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement

Arid

DOI	10.3390/v15040969
	Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement
	Woldemariyam, Fanos Tadesse; Kariuki, Christopher Kinyanjui; Kamau, Joseph; De Vleeschauwer, Annebel; De Clercq, Kris; Lefebvre, David J.; Paeshuyse, Jan
通讯作者	Woldemariyam, FT ; Paeshuyse, J
来源期刊	VIRUSES-BASEL
EISSN	1999-4915
出版年	2023
卷号	15 期号:4
英文摘要	The Horn of Africa is a large area of arid and semi-arid land, holding about 10% of the global and 40% of the entire African livestock population. The region's livestock production system is mainly extensive and pastoralist. It faces countless problems, such as a shortage of pastures and watering points, poor access to veterinary services, and multiple endemic diseases like foot-and-mouth disease (FMD). Foot-and-mouth disease is one of the most economically important livestock diseases worldwide and is endemic in most developing countries. Within Africa, five of the seven serotypes of the FMD virus (FMDV) are described, but serotype C is not circulating anymore, a burden unseen anywhere in the world. The enormous genetic diversity of FMDV is favored by an error-prone RNA-dependent RNA polymerase, intra-typic and inter-typic recombination, as well as the quasi-species nature of the virus. This paper describes the epidemiological dynamics of foot-and-mouth disease in the Horn of Africa with regard to the serotypes and topotypes distribution of FMDV, the livestock production systems practiced, animal movement, the role of wildlife, and the epidemiological complexity of FMD. Within this review, outbreak investigation data and serological studies confirm the endemicity of the disease in the Horn of Africa. Multiple topotypes of FMDV are described in the literature as circulating in the region, with further evolution of virus diversity predicted. A large susceptible livestock population and the presence of wild ungulates are described as complicating the epidemiology of the disease. Further, the husbandry practices and legal and illegal trading of livestock and their products, coupled with poor biosecurity practices, are also reported to impact the spread of FMDV within and between countries in the region. The porosity of borders for pastoralist herders fuels the unregulated transboundary livestock trade. There are no systematic control strategies in the region except for sporadic vaccination with locally produced vaccines, while literature indicates that effective control measures should also consider virus diversity, livestock movements/biosecurity, transboundary trade, and the reduction of contact with wild, susceptible ungulates.
英文关键词	foot-and-mouth disease virus diversity livestock movement wild ungulates Horn of Africa
类型	Review
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000979489600001
WOS关键词	EAST-AFRICA ; ANTIGENIC CHARACTERIZATION ; FMD VIRUSES ; SEROTYPE ; SEROPREVALENCE ; PREVALENCE ; EVOLUTION ; SELECTION ; LIVESTOCK ; PATTERNS
WOS类目	Virology
WOS研究方向	Virology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/398969
推荐引用方式 GB/T 7714	Woldemariyam, Fanos Tadesse,Kariuki, Christopher Kinyanjui,Kamau, Joseph,et al. Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement[J],2023,15(4).
APA	Woldemariyam, Fanos Tadesse.,Kariuki, Christopher Kinyanjui.,Kamau, Joseph.,De Vleeschauwer, Annebel.,De Clercq, Kris.,...&Paeshuyse, Jan.(2023).Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement.VIRUSES-BASEL,15(4).
MLA	Woldemariyam, Fanos Tadesse,et al."Epidemiological Dynamics of Foot-and-Mouth Disease in the Horn of Africa: The Role of Virus Diversity and Animal Movement".VIRUSES-BASEL 15.4(2023).