干旱区生态环境知识资源中心(Arid): Evaluating Viscosity and Tear Breakup Time of Contemporary Commercial Ocular Lubricants on an In Vitro Eye Model

Arid

DOI	10.1167/tvst.12.6.29
	Evaluating Viscosity and Tear Breakup Time of Contemporary Commercial Ocular Lubricants on an In Vitro Eye Model
	Phan, Chau-Minh; Ross, Mitchell; Fahmy, Karim; McEwen, Blair; Hofmann, Ilan; Chan, Vivian W. Y.; Clark-Baba, Connor; Jones, Lyndon
通讯作者	Phan, CM
来源期刊	TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
ISSN	2164-2591
出版年	2023
卷号	12 期号:6
英文摘要	Purpose: To evaluate the link between the viscosity of ophthalmic formulation and tear film stability using a novel in vitro eye model.Methods: The viscosities and noninvasive tear breakup time (NIKBUT) of 13 commercial ocular lubricants were measured to evaluate the correlation between viscosity and NIKBUT. The complex viscosity of each lubricant was measured three times for each angular frequency (ranging from 0.1 to 100 rad/s) using the Discovery HR-2 hybrid rheometer. The NIKBUT measurements were performed eight times for each lubricant using an advanced eye model mounted on the OCULUS Keratograph 5M. A contact lens (CL; ACUVUE OASYS [etafilcon A]) or a collagen shield (CS) was used as the simulated corneal surface. Phosphate-buffered saline was used as a simulated fluid.Results: The results showed a positive correlation between viscosity and NIKBUT at high shear rates (at 10 rad/s, r = 0.67) but not at low shear. This correlation was even better for viscosities between 0 and 100 mPa*s (r = 0.85). Most of the lubricants tested in this study also had shear-thinning properties. OPTASE INTENSE, I-DROP PUR GEL, I DROP MGD, OASIS TEARS PLUS, and I-DROP PUR had higher viscosity in comparison to other lubricants (P < 0.05). All of the formulations had a higher NIKBUT than the control (2.7 +/- 1.2 seconds for CS and 5.4 +/- 0.9 seconds for CL) without any lubricant (P < 0.05). I-DROP PUR GEL, OASIS TEARS PLUS, I-DROP MGD, REFRESH OPTIVE ADVANCED, and OPTASE INTENSE had the highest NIKBUT using this eye model.Conclusions: The results show that the viscosity is correlated with NIKBUT, but further work is necessary to determine the underlying mechanisms.Translational Relevance: The viscosity of ocular lubricants can affect NIKBUT and tear film stability, so it is an important property to consider when formulating ocular lubricants.
英文关键词	viscosity ocular lubricants in vitro eye model tear breakup
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:001108907400003
WOS关键词	UP TIME ; FILM ; FORMULATIONS ; DISEASE ; SYSTEMS
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/398919
推荐引用方式 GB/T 7714	Phan, Chau-Minh,Ross, Mitchell,Fahmy, Karim,et al. Evaluating Viscosity and Tear Breakup Time of Contemporary Commercial Ocular Lubricants on an In Vitro Eye Model[J],2023,12(6).
APA	Phan, Chau-Minh.,Ross, Mitchell.,Fahmy, Karim.,McEwen, Blair.,Hofmann, Ilan.,...&Jones, Lyndon.(2023).Evaluating Viscosity and Tear Breakup Time of Contemporary Commercial Ocular Lubricants on an In Vitro Eye Model.TRANSLATIONAL VISION SCIENCE & TECHNOLOGY,12(6).
MLA	Phan, Chau-Minh,et al."Evaluating Viscosity and Tear Breakup Time of Contemporary Commercial Ocular Lubricants on an In Vitro Eye Model".TRANSLATIONAL VISION SCIENCE & TECHNOLOGY 12.6(2023).