干旱区生态环境知识资源中心(Arid): Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment

Arid

DOI	10.1016/j.talanta.2023.124762
	Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment
	Ivankovic, Klaudija; Jambrosic, Karlo; Mikac, Iva; Kapetanovic, Damir; Ahel, Marijan; Terzic, Senka
通讯作者	Terzic, S
来源期刊	TALANTA
ISSN	0039-9140
EISSN	1873-3573
出版年	2023
卷号	264
英文摘要	In this work, a wide-scope liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of environmental levels of multiclass drugs and their metabolites in water and fish samples was developed. The method allowed the reliable determination of 44 drugs, covering a rather wide range of chemistries and physicochemical characteristics. In order to obtain a reliable and robust analytical protocol, different combinations of extraction and cleanup techniques were systematically examined. Aqueous samples were extracted using a simple Oasis HLB SPE enrichment protocol with pH-optimized sample percolation (pH 3). The extraction of cryo-homogenized biota samples was performed using double extraction with MeOH basified with 0.5% NH3, which allowed high extraction recoveries for all target analytes. The problem of the coextracted lipid matrix, which is known to be the key obstacle for reliable biota analysis, was systematically examined in a series of model cleanup experiments. A combination of cryo-precipitation, filtration, and HLB SPE cleanup was proposed as a protocol, which allowed reliable and robust analysis of all target compounds at low ng/g levels. At the final conditions, the method which was validated at three concentration levels showed high extraction recoveries (68-97%), acceptable matrix effects (12 to -32%), accuracies (81-129%), and reproducibilities (3-32%) for all analytes. The developed method was used to determine drug concentrations in river water and in feral freshwater fish, including whole fish and muscle tissue, from the Sava River (Croatia), in order to estimate their corresponding bioaccumulation potential. With respect to bioaccumulation potential in whole fish and fish muscle, the most relevant drugs were lisinopril, sertraline, terbinafine, torsemide, diazepam, desloratadine, and loratadine with estimated bioaccumulation factors ranging from 20 to 838 and from 1 to 431, respectively.
英文关键词	Pharmaceuticals Biota Surface water Organic contaminants Bioaccumulation
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:001053069300001
WOS关键词	PERSONAL CARE PRODUCTS ; LIQUID-CHROMATOGRAPHY ; ILLICIT DRUGS ; PHARMACEUTICALS ; CONTAMINANTS ; ENVIRONMENT ; EXTRACTION ; CHEMICALS ; RIVERS ; AREAS
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/398888
推荐引用方式 GB/T 7714	Ivankovic, Klaudija,Jambrosic, Karlo,Mikac, Iva,et al. Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment[J],2023,264.
APA	Ivankovic, Klaudija,Jambrosic, Karlo,Mikac, Iva,Kapetanovic, Damir,Ahel, Marijan,&Terzic, Senka.(2023).Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment.TALANTA,264.
MLA	Ivankovic, Klaudija,et al."Multiclass determination of drug residues in water and fish for bioaccumulation potential assessment".TALANTA 264(2023).